International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3145 - 3145
Опубликована: Фев. 5, 2023
The
skin
is
the
largest
organ
of
body
and
consists
an
epidermis,
dermis
subcutaneous
adipose
tissue.
surface
area
often
stated
to
be
about
1.8
2
m2
represents
our
interface
with
environment;
however,
when
one
considers
that
microorganisms
live
in
hair
follicles
can
enter
sweat
ducts,
interacts
this
aspect
environment
becomes
25–30
m2.
Although
all
layers
skin,
including
tissue,
participate
antimicrobial
defense,
review
will
focus
mainly
on
role
factors
epidermis
at
surface.
outermost
layer
stratum
corneum,
physically
tough
chemically
inert
which
protects
against
numerous
environmental
stresses.
It
provides
a
permeability
barrier
attributable
lipids
intercellular
spaces
between
corneocytes.
In
addition
barrier,
there
innate
involves
lipids,
peptides
proteins.
has
low
pH
poor
certain
nutrients,
limits
range
survive
there.
Melanin
trans-urocanic
acid
provide
protection
from
UV
radiation,
Langerhans
cells
are
poised
monitor
local
trigger
immune
response
as
needed.
Each
these
protective
barriers
discussed.
Journal of the European Academy of Dermatology and Venereology,
Год журнала:
2023,
Номер
37(S3), С. 7 - 15
Опубликована: Янв. 13, 2023
Abstract
Skin
wounds
are
common
and
represent
a
major
public
health
economical
problem,
with
risks
of
complications
significant
negative
impact
on
the
quality
life
patients.
Cutaneous
wound
healing
is
tightly
regulated
process
resulting
in
restoration
tissue
integrity.
Wound
involves
interaction
several
skin,
immune
vascular
cells,
growth
factors
cytokines.
However,
external
actors
can
play
an
important
role
healing,
such
as
skin
microbiome,
which
microbial
commensal
collection
bacteria,
fungi
viruses
inhabiting
skin.
Indeed,
recent
advances
have
featured
interactions,
within
environment,
between
different
species
host
system.
This
article
reviews
relationship
microbiome
process.
Although
cutaneous
potential
entry
site
for
infection,
either
detrimental
or
beneficial
healing.
Thus,
targeting
could
essential
part
management.
Molecules,
Год журнала:
2023,
Номер
28(6), С. 2501 - 2501
Опубликована: Март 9, 2023
The
goal
of
the
current
work
was
to
create
an
antibacterial
agent
by
using
polycaprolactone/chitosan
(PCL/CH)
nanofibers
loaded
with
Cordia
myxa
fruit
extract
(CMFE)
as
antimicrobial
for
wound
dressing.
Several
characteristics,
including
morphological,
physicomechanical,
and
mechanical
surface
wettability,
activity,
cell
viability,
in
vitro
drug
release,
were
investigated.
inclusion
CMFE
PCL/CH
led
increased
swelling
capability
maximum
weight
loss.
SEM
images
PCL/CH/CMFE
mat
showed
a
uniform
topology
free
beads
average
fiber
diameter
195.378
nm.
Excellent
activity
shown
towards
Escherichia
coli
(31.34
±
0.42
mm),
Salmonella
enterica
(30.27
0.57
Staphylococcus
aureus
(21.31
0.17
Bacillus
subtilis
(27.53
1.53
Pseudomonas
aeruginosa
(22.17
0.12
mm)
based
on
inhibition
zone
assay.
sample
containing
5
wt%
had
lower
water
contact
angle
(47
3.7°),
high
porosity,
compared
neat
mat.
release
5%
CMFE-loaded
proven
be
anomalous
non-Fickian
diffusion
Korsmeyer-Peppas
model.
Compared
pure
PCL
membrane,
PCL-CH/CMFE
membrane
exhibited
suitable
cytocompatibility
L929
cells.
In
conclusion,
fabricated
nanofibrous
films
demonstrated
bioavailability,
properties
that
can
used
dressings.
Lipid
synthesis
is
necessary
for
formation
of
epithelial
barriers
and
homeostasis
with
external
microbes.
An
analysis
the
response
human
keratinocytes
to
several
different
commensal
bacteria
on
skin
revealed
that
Cutibacterium
acnes
induced
a
large
increase
in
essential
lipids
including
triglycerides,
ceramides,
cholesterol,
free
fatty
acids.
A
similar
occurred
mouse
epidermis
affected
acne.
Further
showed
this
was
mediated
by
short-chain
acids
produced
dependent
increased
expression
lipid
genes
glycerol-3-phosphate-acyltransferase-3.
Inhibition
or
RNA
silencing
peroxisome
proliferator-activated
receptor-α
(PPARα),
but
not
PPARβ
PPARγ,
blocked
response.
The
keratinocyte
content
improved
innate
barrier
functions
antimicrobial
activity,
paracellular
diffusion,
transepidermal
water
loss.
These
results
reveal
metabolites
from
common
bacterium
have
previously
unappreciated
influence
composition
epidermal
lipids.
Molecular Pharmaceutics,
Год журнала:
2023,
Номер
20(7), С. 3278 - 3297
Опубликована: Июнь 6, 2023
In
recent
years,
significant
progress
has
been
made
in
transdermal
drug
delivery
systems,
but
there
is
still
a
search
for
enhancers
that
can
improve
the
absorption
of
active
substances
through
stratum
corneum.
Although
permeation
have
described
scientific
literature,
use
naturally
occurring
this
role
particular
interest,
because
they
offer
high
level
safety
use,
with
low
risk
skin
irritation,
and
efficiency.
addition,
these
ingredients
are
biodegradable,
easily
available,
widely
accepted
by
consumers
due
to
growing
trust
natural
compounds.
This
article
provides
information
on
derived
compounds
systems
help
them
penetrate
skin.
The
work
focuses
components
found
corneum
such
as
sterols,
ceramides,
oleic
acid,
urea.
Penetration
nature,
mainly
plants,
terpenes,
polysaccharides,
fatty
acids
also
described.
mechanism
action
discussed,
methods
assessing
their
penetration
efficiency
provided.
Our
review
covers
original
papers
from
2017
2022,
supplemented
papers,
then
older
publications
used
supplement
or
verify
data.
shown
increase
transport
compete
synthetic
counterparts.
Molecular Psychiatry,
Год журнала:
2023,
Номер
28(9), С. 3625 - 3637
Опубликована: Сен. 1, 2023
Abstract
The
human
body
harbors
a
diverse
ecosystem
of
microorganisms,
including
bacteria,
viruses,
and
fungi,
collectively
known
as
the
microbiota.
Current
research
is
increasingly
focusing
on
potential
association
between
microbiota
various
neuropsychiatric
disorders.
resides
in
parts
body,
such
oral
cavity,
nasal
passages,
lungs,
gut,
skin,
bladder,
vagina.
gut
gastrointestinal
tract
has
received
particular
attention
due
to
its
high
abundance
role
psychiatric
neurodegenerative
However,
presents
other
tissues,
though
less
abundant,
also
plays
crucial
immune
system
homeostasis,
thus
influencing
development
progression
For
example,
imbalance
associated
periodontitis
might
increase
risk
for
Additionally,
studies
using
postmortem
brain
samples
have
detected
widespread
presence
bacteria
brains
patients
with
Alzheimer’s
disease.
This
article
provides
an
overview
emerging
host
disorders
discusses
future
directions,
underlying
biological
mechanisms,
reliable
biomarkers
microbiota,
microbiota-targeted
interventions,
this
field.
Cell Host & Microbe,
Год журнала:
2024,
Номер
32(4), С. 506 - 526.e9
Опубликована: Март 12, 2024
To
understand
the
dynamic
interplay
between
human
microbiome
and
host
during
health
disease,
we
analyzed
microbial
composition,
temporal
dynamics,
associations
with
multi-omics,
immune,
clinical
markers
of
microbiomes
from
four
body
sites
in
86
participants
over
6
years.
We
found
that
stability
individuality
are
body-site
specific
heavily
influenced
by
host.
The
stool
oral
more
stable
than
skin
nasal
microbiomes,
possibly
due
to
their
interaction
environment.
identify
individual-specific
commonly
shared
bacterial
taxa,
individualized
taxa
showing
greater
stability.
Interestingly,
dynamics
correlate
across
sites,
suggesting
systemic
host-microbial-environment
interactions.
Notably,
insulin-resistant
individuals
show
altered
among
microbiome,
molecular
markers,
features,
disrupted
metabolic
disease.
Our
study
offers
comprehensive
views
multi-site
relationship
Microneedles
(MNs)
can
be
used
for
the
topical
treatment
of
skin
disorders
as
they
directly
deliver
therapeutics
to
site
lesions,
resulting
in
increased
therapeutic
efficacy
while
having
minimum
side
effects.
MNs
are
different
kinds
(e.g.,
small
molecules,
macromolecules,
nanomedicines,
living
cells,
bacteria,
and
exosomes)
treating
various
disorders,
including
superficial
tumors,
wounds,
infections,
inflammatory
diseases,
abnormal
appearance.
The
improved
by
integrating
advantages
multiple
perform
combination
therapy.
Through
careful
designing,
further
modified
with
biomimetic
structures
responsive
drug
release
from
internal
external
stimuli
enhance
transdermal
delivery
efficiency
robust
outcomes.
Some
studies
have
proposed
use
drug-free
a
promising
mechanotherapeutic
strategy
promote
wound
healing,
scar
removal,
hair
regeneration
via
mechanical
communication
pathway.
Although
several
advantages,
practical
application
suffers
problems
related
industrial
manufacture
clinical
evaluation,
making
it
difficult
translation.
In
this
study,
we
summarized
applications,
emerging
challenges,
developmental
prospects
provide
information
on
ways
advance
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(22)
Опубликована: Фев. 1, 2024
Abstract
The
skin,
as
the
body's
largest
organ,
is
closely
linked
to
an
individual's
health.
Delayed
diagnosis
and
treatment
of
skin
infections
can
lead
complications
such
non‐healing
wounds
sepsis.
Despite
significant,
early
identification
wound
timely
remain
a
challenge
that
requires
continuous
management.
This
work
presents
novel
strategy
combines
smart
microneedle
sensing
inhibit
infection
track
healing
status.
tip
based
on
metal‐organic
frameworks
(MOF)
hydrogel
allows
rapid
self‐sterilization
promotes
healing.
substrate
patch
pH–sensitive
fluorescent
reagents,
integrate
with
smartphone
visualize
images.
Furthermore,
it
be
further
reliably
evaluated
pH
by
applying
machine‐learning
algorithm.
multifunctional
establishes
therapy
address
delayed
management,
design
optimization
MOF
hydrogels,
contributes
facile
way
for
disease
personalized
health
