Chemical Engineering Journal, Год журнала: 2023, Номер 470, С. 143986 - 143986
Опубликована: Июнь 7, 2023
Язык: Английский
Environment International, Год журнала: 2024, Номер 185, С. 108535 - 108535
Опубликована: Фев. 27, 2024
Ultraviolet (UV) radiation is ubiquitous in the environment, which has been classified as an established human carcinogen. As largest and outermost organ of body, direct exposure skin to sunlight or UV can result sunburn, inflammation, photo-immunosuppression, photoaging even cancers. To date, there are tactics protect by preventing reducing amount skin. Nevertheless, deciphering essential regulatory mechanisms may pave way for therapeutic interventions against UV-induced disorders. Additionally, light considered beneficial specific skin-related conditions medical therapy. Recent evidence indicates that biological effects extend beyond include treatment inflammatory diseases, solid tumors certain abnormal behaviors. This review mainly focuses on Moreover, novel findings other organs systems also summarized. through affects organism remain be fully elucidated achieve a more comprehensive understanding its effects.
Язык: Английский
Процитировано
84
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3790 - 3790
Опубликована: Март 28, 2024
Cutaneous wound healing is a complex biological process involving series of well-coordinated events aimed at restoring skin integrity and function. Various experimental models have been developed to study the mechanisms underlying repair evaluate potential therapeutic interventions. This review explores diverse array utilized in research, ranging from rodent excisional wounds advanced tissue engineering constructs microfluidic platforms. More importantly, influence lipids on examined, emphasizing their role enhancing barrier function restoration, modulating inflammation, promoting cell proliferation, remodeling. Lipids, such as phospholipids, sphingolipids, ceramides, play crucial roles membrane structure, signaling, repair. Understanding interplay between microenvironment provides valuable insights into development novel strategies for efficient regeneration. highlights significance investigating elucidating intricate involvement process, offering avenues improving clinical outcomes management.
Язык: Английский
Процитировано
29
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3145 - 3145
Опубликована: Фев. 5, 2023
The skin is the largest organ of body and consists an epidermis, dermis subcutaneous adipose tissue. surface area often stated to be about 1.8 2 m2 represents our interface with environment; however, when one considers that microorganisms live in hair follicles can enter sweat ducts, interacts this aspect environment becomes 25–30 m2. Although all layers skin, including tissue, participate antimicrobial defense, review will focus mainly on role factors epidermis at surface. outermost layer stratum corneum, physically tough chemically inert which protects against numerous environmental stresses. It provides a permeability barrier attributable lipids intercellular spaces between corneocytes. In addition barrier, there innate involves lipids, peptides proteins. has low pH poor certain nutrients, limits range survive there. Melanin trans-urocanic acid provide protection from UV radiation, Langerhans cells are poised monitor local trigger immune response as needed. Each these protective barriers discussed.
Язык: Английский
Процитировано
40
Microorganisms, Год журнала: 2023, Номер 11(6), С. 1420 - 1420
Опубликована: Май 27, 2023
The skin microbiota is a pivotal contributor to the maintenance of homeostasis by protecting it from harmful pathogens and regulating immune system. An imbalance in can lead pathological conditions such as eczema, psoriasis, acne. balance components be disrupted different elements dynamics changes pH levels, exposure environmental toxins, use certain skincare products. Some research suggests that probiotic strains their metabolites (postbiotics) may provide benefits improving barrier function, reducing inflammation, appearance acne-prone or eczema-prone skin. Consequently, recent years probiotics postbiotics have become popular ingredient Moreover, was demonstrated health influenced skin–gut axis, imbalances gut microbiome caused poor diet, stress, antibiotics conditions. In this way, products improve been gaining attention cosmetic pharmaceutical companies. present review will focus on crosstalk between SM host, its effects diseases.
Язык: Английский
Процитировано
39
Fermentation, Год журнала: 2023, Номер 9(3), С. 264 - 264
Опубликована: Март 7, 2023
The skin microbiome is composed of a complex association bacteria, fungi, and viruses. maintenance commensal microbes essential for preventing the overgrowth pathogenic microorganisms or already present opportunistic pathogens. Thus, development bioactive compounds capable modulating has become an important topic both researchers cosmetic industry. Increasingly, scientific evidence highlights that metabolites derived from probiotics have great potential to prevent diseases affecting skin. These recently been called postbiotics are defined as “preparation inanimate and/or their components confers health benefit on host”. Postbiotics obtained fermentations performed almost exclusively by lactic acid bacteria yeast. Short-chain fatty acids, bacteriocins, organic acids some examples postbiotics. exhibit antimicrobial, immunomodulatory, antioxidant, anti-inflammatory activities. In addition, postbiotic production possesses technological advantages, including high stability increased safety, compared viable probiotics. this article, model large-scale uses in formulations reviewed. results vivo tests treatment alopecia, acne, atopic dermatitis, wound healing discussed. Finally, advances shown based survey main patents filed area
Язык: Английский
Процитировано
38
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(20)
Опубликована: Март 19, 2023
Abstract Radiotherapy is one of the most important means cancer treatment, however, radiation can also cause adverse reactions and even serious injuries to skin. Radiation‐induced excess reactive oxygen species (ROS) production inflammatory infiltration make skin wounds difficult heal compared normal injuries. Herein, an antioxidant heparin‐mimetic peptide hydrogel (K16, KYKYEYEYAGEGDSS‐4Sa) designed for radiation‐induced injury (RISI) repair. First, K16 self‐assemble into a with 3D mesh‐like porous nanofiber structure, which provide certain physical support repair like extracellular matrix (ECM). Then, not only scavenges ROS prevents damage cellular DNA, but promotes cell proliferation, migration, angiogenesis. Meanwhile, 4‐sulfobenzoic acid (4Sa) modified at N‐terminal end adsorb cytokines, thus acting eliminate inflammation wound site. In vivo experiments showed that inhibit early degradation, reduce infiltration, promote angiogenesis collagen deposition, promoting healing. Therefore, in this study has good potential application field
Язык: Английский
Процитировано
28
Frontiers in Physiology, Год журнала: 2024, Номер 15
Опубликована: Янв. 19, 2024
The interplay between the microbes and skin barrier holds pivotal significance in health aging. gut, both of which are critical immune neuroendocrine system, harbor that kept balance. Microbial shifts seen with aging may accelerate age-related changes. This comprehensive review investigates intricate connection microbe dynamics, barrier, process. gut plays essential roles human body, safeguarding host, modulating metabolism, shaping immunity. Aging can perturb microbiome turn accentuates inflammaging by further promoting senescent cell accumulation compromising host’s response. Skin microbiota diligently upholds epidermal adeptly fending off pathogens. encompasses alterations stratum corneum structure lipid content, negatively impact skin’s function decreased moisture retention increased vulnerability to infection. Efficacious restoration dysbiosis strategic integration acidic cleansers, emollients optimal composition, antioxidants, judicious photoprotection be a proactive approach Furthermore, modulation gut-skin axis through probiotics, prebiotics, postbiotics emerges as promising avenue enhance studies have substantiated their efficacy enhancing hydration, reducing wrinkles, fortifying integrity. In summary, is intrinsically woven into tapestry Sound understanding these interactions, coupled interventions aimed at recalibrating equilibrium, potential ameliorate Further in-depth necessary better understand skin-aging develop targeted strategies for successful
Язык: Английский
Процитировано
15
MedComm, Год журнала: 2024, Номер 5(10)
Опубликована: Сен. 15, 2024
The innate immune system serves as the body's first line of defense, utilizing pattern recognition receptors like Toll-like to detect pathogens and initiate rapid response mechanisms. Following this initial response, adaptive immunity provides highly specific sustained killing via B cells, T antibodies. Traditionally, it has been assumed that activates immunity; however, recent studies have revealed more complex interactions. This review a detailed dissection composition function systems, emphasizing their synergistic roles in physiological pathological contexts, providing new insights into link between these two forms immunity. Precise regulation both systems at same time is beneficial fight against immune-related diseases, for example, cGAS-STING pathway found play an important role infections cancers. In addition, paper summarizes challenges future directions field immunity, including latest single-cell sequencing technologies, CAR-T cell therapy, checkpoint inhibitors. By summarizing developments, aims enhance our understanding complexity interactions perspectives system.
Язык: Английский
Процитировано
15
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Апрель 19, 2024
All microorganisms like bacteria, viruses and fungi that reside within a host environment are considered microbiome. The number of bacteria almost equal human cells, however, the genome these may be 100 times larger than genome. Every aspect physiology health can influenced by microbiome living in various parts our body. Any imbalance composition or function is seen as dysbiosis. Different types dysbiosis corresponding symptoms depend on site microbial imbalance. contribution intestinal extra-intestinal microbiota to influence systemic activities through interplay between different axes. Whole body complex process involving gut non-gut related It still at stage infancy has not yet been fully understood. Dysbiosis genetic factors, lifestyle habits, diet including ultra-processed foods food additives, well medications. associated with many diseases cannot diagnosed standard blood tests investigations. Microbiota derived metabolites analyzed useful management addressed altering proper modulation. effect interventions humans depends beneficial alteration mostly based animal studies evolving evidence from studies. There tremendous potential for diagnosis, treatment, prognosis diseases, as, monitoring disease humans. system-based approach diagnosis better pure taxonomic approach. could new therapeutic target conditions.
Язык: Английский
Процитировано
12
Dermatology and Therapy, Год журнала: 2024, Номер 14(1), С. 45 - 57
Опубликована: Янв. 1, 2024
Atopic dermatitis (AD) is a chronic, relapsing immunoinflammatory skin condition characterized by sensations such as pruritis, pain, and neuronal hypersensitivity. The mechanisms underlying these are multifactorial involve complex crosstalk among several cutaneous components. This review explores the role components play in pathophysiology of atopic dermatitis. In intercellular spaces, sensory nerves interact with keratinocytes immune cells via myriad mediators receptors. These interactions generate action potentials that transmit pruritis pain signals from peripheral nervous system to brain. Keratinocytes, most abundant cell type epidermis, key effector cells, triggering neurons elicit inflammation. Filaggrin expression reduced dermatitis, causing weakened barrier elevated pH. Fibroblasts main dermis and, appear reduce keratinocyte differentiation, further weakening barrier. mast promote inflammation while dermal dendritic attenuate Inflammatory cytokines chemokines major AD pathogenesis. Type 2 responses typically 1 3 pain. increased pH contribute dysfunction dysbiosis microbiome, proliferation Staphyloccocus aureus. conclusion, understanding dynamic between could drive development therapies improve quality life for patients AD.
Язык: Английский
Процитировано
10