International Journal of Biometeorology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Фев. 22, 2024
There exists a bidirectional relationship between oral health and general well-being, with an imbalance in symbiotic flora posing threat to overall human health. Disruptions the commensal can lead diseases, while systemic illnesses also impact cavity, resulting development of diseases disorders. Porphyromonas gingivalis Fusobacterium nucleatum , known as pathogenic bacteria associated periodontitis, play crucial role linking periodontitis accompanying diseases. In periodontal tissues, these bacteria, along their virulence factors, excessively activate host immune system through local diffusion, lymphatic circulation, blood transmission. This response disruption contributes osteoimmune mechanisms, alveolar bone resorption, potential inflammation. To restore homeostasis, deeper understanding microbiota–host interactions network phenotype tissues is imperative. Defining offers promising avenue for investigating complex characteristics plaque biofilms exploring review aims provide overview mechanisms underlying - -induced well immunophenotypes observed during pathological conditions.
Язык: Английский
Процитировано
6
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Окт. 16, 2024
In patients with rheumatoid arthritis (RA), intestinal flora imbalance and butyrate metabolism disorders precede clinical are associated the pathogenesis of RA. This can alter immunology permeability mucosa, leading to damage barrier. this context, bacteria their metabolites enter bloodstream reach distant target tissues host, resulting in local inflammation aggravating arthritis. Additionally, is also exacerbated by bone destruction immune tolerance due disturbed differentiation osteoclasts adaptive cells. Of note, a metabolite flora, which not only locally inhibits immunity targets zonulin tight junction proteins alleviate barrier-mediated but autoantibodies balances responses T B lymphocytes throughout body repress erosion inflammation. Therefore, key intermediate linking host. As result, restoring butyrate-producing capacity using exogenous potential therapeutic strategies for RA future.
Язык: Английский
Процитировано
6
Periodontology 2000, Год журнала: 2024, Номер unknown
Опубликована: Фев. 27, 2024
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks provide an update interventional mechanistic investigations, including a brief summary European Research programs investigating link between Recent clinical studies are described that evaluate treatment one disease impacts other, as in humans animal models have sought identify potential mechanisms linking two diseases.
Язык: Английский
Процитировано
5
RMD Open, Год журнала: 2024, Номер 10(1), С. e003847 - e003847
Опубликована: Март 1, 2024
Although elevated levels of neutrophil extracellular traps (NETs) have been reported in patients with rheumatoid arthritis (RA), the role NETs RA and relationship between macrophages pathogenesis requires further research. Here, we sought to determine reveal potential mechanism.
Язык: Английский
Процитировано
5
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116515 - 116515
Опубликована: Апрель 2, 2024
Mesenchymal stem cell exosome (MSCs-exo) is a class of products secreted by mesenchymal cells (MSCs) that contain various biologically active substances. MSCs-exo promising alternative to MSCs due their lower immunogenicity and lack ethical constraints. Ginsenoside Rh2 (Rh2) hydrolyzed component the primary substance ginsenosides. has variety pharmacological functions, including anti-inflammatory, anti-tumor, antioxidant. Studies have demonstrated gut microbiota metabolites are critical in developing rheumatoid arthritis (RA). In this study, we constructed collagen-induced (CIA) model rats. We used combined with treat CIA To observe effect on joint inflammation, rat feces were collected for 16 rRNA amplicon sequencing untargeted metabolomics analysis. The results showed index score swelling rats treated combination significantly than those alone groups. ameliorated disturbed regulation Candidatus_Saccharibacteria Clostridium_XlVb may be most critical. enhanced therapeutic compared -alone group. Furthermore, significant changes observed group, these differentially altered act as messengers host-microbiota interactions. These differential enriched into relevant metabolic pathways, revealing possible pathways
Язык: Английский
Процитировано
5
Microbiological Research, Год журнала: 2024, Номер 285, С. 127788 - 127788
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
5
Cell Metabolism, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
5
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3630 - 3630
Опубликована: Апрель 11, 2025
Increased abundance of Segatella copri (S. copri) within the gut microbiota is associated with systemic inflammatory diseases, including rheumatoid arthritis. Although outer-membrane vesicles (OMVs) Gram-negative bacteria are important players in microbiota–host communication, effect S. copri-derived OMVs on immune cells unknown. Macrophages engulf and eliminate foreign material conditioned by environmental signals to promote either homeostasis or inflammation. Thus, we aimed explore impact copri-OMVs human macrophages vitro, employing THP-1 monocyte-derived macrophage models. The uptake DiO-labeled into was monitored confocal microscopy flow cytometry. Furthermore, phenotype cytokine secretion naïve (M0), pro-inflammatory (M1), anti-inflammatory (M2) analyzed cytometry ELISA, respectively. We show that enter through macropinocytosis clathrin-dependent mechanisms. copri-OMVs, but not parental bacterium, induced a dose-dependent increase expression M1-related surface markers M0 M2 activated large amounts cytokines M1 macrophages. These results highlight an role promoting responses, which might contribute diseases.
Язык: Английский
Процитировано
0
Cell Cycle, Год журнала: 2024, Номер 23(3), С. 294 - 307
Опубликована: Фев. 1, 2024
The increase of the Fusobacterium nucleatum level has been previously identified in various cancers including gastric cancer (GC), but how F. exerts its carcinogenic role GC remains unclear. Several studies revealed that contributes to progression via secretion extracellular vehicles (EVs). Hence, it's designed reveal influence nucleatum-derived EVs (Fn-EVs) progression. tumor and adjacent tissues were collected from 30 patients, abundance was found be highly expressed samples. ultracentrifugation employed isolate Escherischia coli (E. coli), which labeled Fn-EVs E. coli-EVs, respectively. After treating cells with cell counting kit 8, colony formation, wound healing as well transwell assay performed, effectively enhanced oxaliplatin resistance, facilitated proliferation, migration, invasion, stemness while coli-EVs exert no significant effect on cells. Besides, DNA repair also by Fn-EVs, sphere-forming detection stemness- repair-associated proteins western blotting. In vivo analyses demonstrated administration not only promoted growth liver metastasis conferred resistance resistance. This study first contributive development provided a better perspective for manipulating patients malignant phenotypes.
Язык: Английский
Процитировано
4
Immunological Reviews, Год журнала: 2024, Номер 325(1), С. 107 - 130
Опубликована: Июнь 12, 2024
Autoimmune (or rheumatic) diseases are increasing in prevalence but selecting the best therapy for each patient proceeds trial-and-error fashion. This strategy can lead to ineffective resulting irreversible damage and suffering; thus, there is a need bring promise of precision medicine patients with autoimmune disease. While host factors partially determine therapeutic response immunosuppressive drugs, these not routinely used tailor therapy. Thus, non-host likely contribute. Here, we consider impact human gut microbiome treatment autoimmunity. We propose that be manipulated improve derive greater benefit from existing therapies. focus on mechanisms by which impacts response, provide framework interrogate mechanisms, review case study widely-used anti-rheumatic drug, discuss challenges studying multiple complex systems: microbiome, immune system, open questions remain field speculate future drug-microbiome-autoimmune disease interactions. Finally, present blue-sky vision how rheumatic
Язык: Английский
Процитировано
4