Inventions,
Год журнала:
2025,
Номер
10(2), С. 31 - 31
Опубликована: Апрель 18, 2025
Biosensors
based
on
the
surface
plasmon
resonance
(SPR)
technique
are
widely
used
for
analyte
detection
due
to
their
high
selectivity
and
real-time
capabilities.
However,
conventional
SPR
spectrum
analysis
can
be
affected
by
experimental
noise
environmental
variations,
reducing
accuracy
of
results.
To
address
these
limitations,
this
study
presents
development
an
open-source
computational
tool
optimize
biosensor
characterization,
implemented
using
MATLAB
App
Designer
(Version
R2024b).
The
enables
importation
data,
application
different
smoothing
methods,
integration
traditional
hybrid
approaches
enhance
in
determining
angle.
proposed
offers
several
innovations,
such
as
both
(angle
vs
wavelength)
modes,
implementation
four
advanced
curve
techniques,
including
Gaussian
filter,
Savitzky–Golay,
splines,
EWMA,
well
a
user-friendly
graphical
interface
supporting
data
visualization,
import,
result
export.
Unlike
approaches,
framework
multidimensional
optimization
parameters,
resulting
greater
robustness
detecting
conditions.
Experimental
validation
demonstrated
marked
reduction
spectral
improved
consistency
angle
across
results
confirm
effectiveness
practical
relevance
tool,
contributing
advancement
analysis.
ACS Sensors,
Год журнала:
2024,
Номер
9(4), С. 1666 - 1681
Опубликована: Март 29, 2024
The
hormone
cortisol,
released
as
the
end-product
of
hypothalamic-pituitary-adrenal
(HPA)
axis,
has
a
well-characterized
circadian
rhythm
that
enables
an
allostatic
response
to
external
stressors.
When
pattern
secretion
is
disrupted,
cortisol
levels
are
chronically
elevated,
contributing
diseases
such
heart
attacks,
strokes,
mental
health
disorders,
and
diabetes.
diagnosis
chronic
stress
related
disorders
depends
upon
accurate
measurement
levels;
currently,
it
quantified
using
mass
spectroscopy
or
immunoassay,
in
specialized
laboratories
with
trained
personnel.
However,
these
methods
time-consuming,
expensive
unable
capture
dynamic
biorhythm
hormone.
This
critical
review
traces
path
detection
from
traditional
laboratory-based
decentralised
monitoring
biosensors.
A
complete
picture
biology
pathophysiology
provided,
importance
precision
medicine
style
highlighted.
Antibody-based
immunoassays
still
dominate
pipeline
development
point-of-care
biosensors;
new
molecules
aptamers
molecularly
imprinted
polymers
(MIPs)
combined
technologies
microfluidics,
wearable
electronics,
quantum
dots
offer
improvements
limit
(LoD),
specificity,
shift
toward
rapid
continuous
measurements.
While
variety
different
sensors
devices
have
been
proposed,
there
exists
need
produce
quantitative
tests
for
─
either
can
enable
personalized
approach
management.
be
addressed
by
synergistic
combinations
leverage
low
sample
volumes,
relevant
testing
time,
better
account
cortisol's
shifting
biorhythm.
Trends
diagnostics
hormones
highlighted,
along
insights
into
choice
matrix.
Biosensors,
Год журнала:
2025,
Номер
15(1), С. 35 - 35
Опубликована: Янв. 9, 2025
Surface
Plasmon
Resonance
(SPR)-based
biodetection
systems
have
emerged
as
powerful
tools
for
real-time,
label-free
biomolecular
interaction
analysis,
revolutionizing
fields
such
diagnostics,
drug
discovery,
and
environmental
monitoring.
This
review
highlights
the
foundational
principles
of
SPR,
focusing
on
interplay
evanescent
waves
surface
plasmons
that
underpin
its
high
sensitivity
specificity.
Recent
advancements
in
SPR
technology,
including
enhancements
sensor
chip
materials,
integration
with
nanostructures,
coupling
complementary
detection
techniques,
are
discussed
to
showcase
their
role
improving
analytical
performance.
The
paper
also
explores
diverse
applications
systems,
ranging
from
pathogen
cancer
biomarker
identification
food
safety
monitoring
toxin
analysis.
By
providing
a
comprehensive
overview
technological
progress
emerging
trends,
this
underscores
transformative
potential
SPR-based
addressing
critical
scientific
societal
challenges.
Future
directions
challenges,
miniaturization,
cost
reduction,
expanding
multiplexing
capabilities,
presented
guide
ongoing
research
development
rapidly
evolving
field.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(3), С. 1336 - 1361
Опубликована: Фев. 27, 2024
Over
the
past
decade,
nanotechnology
has
seen
extensive
integration
into
biomedical
applications,
playing
a
crucial
role
in
biodetection,
drug
delivery,
and
diagnostic
imaging.
This
is
especially
important
reproductive
health
care,
which
become
an
emerging
significant
area
of
research.
Global
concerns
have
intensified
around
disorders
such
as
infertility,
endometriosis,
ectopic
pregnancy,
erectile
dysfunction,
benign
prostate
hyperplasia,
sexually
transmitted
infections,
cancers.
Nanotechnology
presents
promising
solutions
to
address
these
by
introducing
innovative
tools
techniques,
facilitating
early
detection,
targeted
improved
imaging
capabilities.
Through
utilization
nanoscale
materials
devices,
researchers
can
craft
treatments
that
are
not
only
more
precise
but
also
effective,
significantly
enhancing
outcomes
healthcare.
Looking
forward,
future
medicine
holds
immense
potential
for
reshaping
diagnostics,
personalized
therapies,
fertility
preservation.
The
nanotechnology-driven
delivery
systems
anticipated
elevate
treatment
effectiveness,
minimize
side
effects,
offer
patients
therapies
efficient.
review
aims
delve
various
types,
properties,
preparation
techniques
nanocarriers
specifically
designed
context
disorders,
shedding
light
on
current
landscape
directions
this
dynamic
field.
