Phytochemical-based therapeutics from traditional eastern medicine: analgesic effects and ion channel modulation

Frontiers in Pain Research, Год журнала: 2025, Номер 6

Опубликована: Янв. 31, 2025

Pain management remains a major challenge in the healthcare system. While synthetic analgesics are widely used for pain management, their effectiveness managing chronic is often limited due to low efficacy or side effects. Thus, there growing interest exploring alternative relief methods, particularly using medicinal plants from traditional Eastern medicine and phytochemicals. Previous studies have demonstrated modulatory effects of various phytochemicals derived herbal on pain-related ion channels, such as voltage-gated sodium channels (Nav), calcium (Ca2+), transient receptor potential (TRP) channels. Since these integral transmission modulation signals, ability specific activate inhibit presents promising avenue development novel analgesics. The goal this review merge insights with channel research highlight natural compounds safe effective management. In regard, we summarize discovery characterization pain-relieving medicine, discuss mechanisms action mimic enhance conventional through modulation.

Язык: Английский

---

Stir-frying duration modulates structural characterization and functional properties of Atractylodes macrocephala polysaccharides

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141489 - 141489

Опубликована: Фев. 27, 2025

Язык: Английский

---

Ultrasound-assisted extraction and antioxidant activity of triterpenoid saponins from Platycodon grandiflorum roots: Optimization, purification, and molecular insights

Industrial Crops and Products, Год журнала: 2024, Номер 223, С. 119877 - 119877

Опубликована: Окт. 23, 2024

Язык: Английский

---

Exploring the Protective Effects of Spinosin Against Advanced Glycation End Product-Induced Cellular Damage Through Modulation RAGE/MAPK/ NF-κB pathway

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105951 - 105951

Опубликована: Янв. 1, 2025

Язык: Английский

---

Melanoidins from stir-frying Atractylodes Macrocephala: Structural characterization, molecular weight distribution, and polyphenol delivery mechanism

Food Chemistry, Год журнала: 2025, Номер unknown, С. 144238 - 144238

Опубликована: Апрель 1, 2025

Язык: Английский

---

Natural polysaccharides: The potential biomacromolecules for treating diabetes and its complications via AGEs-RAGE-oxidative stress axis

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113426 - 113426

Опубликована: Окт. 30, 2024

Язык: Английский

---