Micro-RNAs: Crossroads between the Exposure to Environmental Particulate Pollution and the Obstructive Pulmonary Disease DOI Open Access
Mauro Finicelli, Tiziana Squillaro, Umberto Galderisi

и другие.

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(19), С. 7221 - 7221

Опубликована: Сен. 30, 2020

Environmental pollution has reached a global echo and represents serious problem for human health. Air encompasses set of hazardous substances, such as particulate matter heavy metals (e.g., cadmium, lead, arsenic), strong impact on the environment by affecting groundwater, soil, air. An adaptive response to environmental cues is essential survival, which associated with induction phenotypes. The epigenetic mechanisms regulating expression patterns several genes are promising candidates provide mechanistic prognostic insights into this. Micro-RNAs (miRNAs) fulfil these features given their ability respond factors critical role in determining These molecules present extracellular fluids, organ-, tissue-, or cell-specific. Moreover, experimental settings quantitative qualitative analysis robust, standardized, inexpensive. In this review, we an update miRNAs suitable tools understanding behind physiopathological toxicants value pattern associable specific exposures. We look at evidence processes leading environmental-induced pulmonary disease (i.e., chronic obstructive disease).

Язык: Английский

The role of particle shape in computational modelling of granular matter DOI
Jidong Zhao, Shiwei Zhao, Stefan Luding

и другие.

Nature Reviews Physics, Год журнала: 2023, Номер 5(9), С. 505 - 525

Опубликована: Авг. 10, 2023

Язык: Английский

Процитировано

113
Acute lung injury caused by sepsis: how does it happen? DOI Creative Commons
Baisheng Sun, M. Lei, Jiaqi Zhang

и другие.

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Ноя. 21, 2023

Sepsis is a systemic inflammatory disease caused by severe infections that involves multiple organs, among which the lung most susceptible, leaving patients highly vulnerable to acute injury (ALI). Refractory hypoxemia and respiratory distress are classic clinical symptoms of ALI sepsis, has mortality rate 40%. Despite extensive research on mechanisms exact pathological process not fully understood. This article reviews advances in pathogenesis sepsis focusing treatment regimens adopted practice for corresponding molecular mechanisms. review can only contribute theories but also recommend new strategies related injuries.

Язык: Английский

Процитировано

48
Systematic review of pulmonary toxicity induced by microplastics and nanoplastics: Insights from in vivo and in vitro studies DOI

Reza Nozari asl,

N. Jaafarzadeh, Faezeh Jahedi

и другие.

Annales de Toxicologie Analytique, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

6
Pulmonary drug delivery for acute respiratory distress syndrome DOI Creative Commons
Qinqin Fei, Ian D. Bentley, Samir N. Ghadiali

и другие.

Pulmonary Pharmacology & Therapeutics, Год журнала: 2023, Номер 79, С. 102196 - 102196

Опубликована: Янв. 20, 2023

Язык: Английский

Процитировано

28
Polystyrene nanoplastics mediate oxidative stress, senescence, and apoptosis in a human alveolar epithelial cell line DOI Creative Commons
Cristina Milillo, Eleonora Aruffo, Piero Di Carlo

и другие.

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Май 10, 2024

Background Nanoplastics, an emerging form of pollution, are easily consumed by organisms and pose a significant threat to biological functions due their size, expansive surface area, potent ability penetrate systems. Recent findings indicate increasing presence airborne nanoplastics in atmospheric samples, such as polystyrene (PS), raising concerns about potential risks the human respiratory system. Methods This study investigates impact 800 nm diameter-PS nanoparticles (PS-NPs) on A549, lung adenocarcinoma cell line, examining viability, redox balance, senescence, apoptosis, internalization. We also analyzed expression hallmark genes these processes. Results demonstrated that PS-NPs diameter significantly affected inducing oxidative stress, cellular apoptosis. penetrated cytoplasm A549 cells. These triggered transcription comprised antioxidant network [SOD1 (protein name: superoxide dismutase 1, soluble), SOD2 2, mitochondrial), CAT catalase), Gpx1 glutathione peroxidase 1), HMOX1 heme oxygenase 1)], senescence-associated secretory phenotype [Cdkn1a cyclin-dependent kinase inhibitor 1A), IL1A interleukin 1 alpha), IL1B beta), IL6 6), CXCL8 C-X-C motif chemokine ligand 8)], others involved apoptosis modulation [BAX Bcl2 associated X, regulator), CASP3 caspase 3), BCL2 Bcl2, regulator)]. Conclusion Collectively, this investigation underscores importance concentration (dose-dependent effect) exposure duration pivotal factors assessing toxic effects alveolar epithelial Greater attention needs be directed toward comprehending cancer development with air pollution ensuing environmental toxicological impacts humans other terrestrial mammals.

Язык: Английский

Процитировано

12
Potential health risks of the interaction of microplastics and lung surfactant DOI

Weimeng Shi,

Yan Cao,

Xiaolong Chai

и другие.

Journal of Hazardous Materials, Год журнала: 2021, Номер 429, С. 128109 - 128109

Опубликована: Дек. 17, 2021

Язык: Английский

Процитировано

52
The Role of Pulmonary Surfactants in the Treatment of Acute Respiratory Distress Syndrome in COVID-19 DOI Creative Commons

Shengguang Wang,

Zhen Li, Xinyu Wang

и другие.

Frontiers in Pharmacology, Год журнала: 2021, Номер 12

Опубликована: Июнь 29, 2021

Lung alveolar type-II (AT-II) cells produce pulmonary surfactant (PS), consisting of proteins and lipids. The lipids in PS are primarily responsible for reducing the air-fluid surface tension inside alveoli lungs to prevent atelectasis. two types: hydrophilic hydrophobic. Hydrophilic surfactants opsonisation, thereby protecting from microbial environmental contaminants. Hydrophobic respiratory function. Severe acute syndrome coronavirus-2 (SARS-CoV-2) enters through ACE-2 receptors on replicates AT-II leading etiology Coronavirus disease – 2019 (COVID-19). SARS-CoV-2 virus damages results decreased production PS. clinical symptoms distress (ARDS) COVID-19 patients like those neonatal (NRDS). treatment is first-line option NRDS found be well tolerated ARDS with inconclusive efficacy. Over past 70°years, a lot research underway natural/synthetic developing systems delivering directly lungs, addition finding association between levels illnesses. In present pandemic situation, scientific community all over world searching effective therapeutic options improve outcomes. With strong evidence-based background role lung homeostasis infection, few trials were initiated evaluate functions COVID-19. Here, we connect data reference physiology infection its possible benefit patients.

Язык: Английский

Процитировано

45
Physicochemical properties of nanoparticles affecting their fate and the physiological function of pulmonary surfactants DOI
Qiaoyu Liu, Jian Guan,

Ruxiao Song

и другие.

Acta Biomaterialia, Год журнала: 2021, Номер 140, С. 76 - 87

Опубликована: Ноя. 26, 2021

Язык: Английский

Процитировано

43
Alveolar macrophages: Achilles’ heel of SARS-CoV-2 infection DOI Creative Commons
Zhenfeng Wang,

Shunshun Li,

Bo Huang

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Июль 19, 2022

Abstract The coronavirus disease 2019 (COVID-19) pandemic has caused more than 6.3 million deaths to date. Despite great efforts curb the spread of severe acute respiratory syndrome 2 (SARS-CoV-2), vaccines and neutralizing antibodies are in gloom due persistent viral mutations antiviral compounds face challenges specificity safety. In addition, unable treat already-infected individuals, drugs cannot be used prophylactically. Therefore, exploration unconventional strategies current is highly urgent. Alveolar macrophages (AMs) residing on surface alveoli first immune cells that dispose alveoli-invading viruses. Our findings demonstrate M1 AMs have an acidic endosomal pH, thus favoring SARS-CoV-2 leave endosomes release into cytosol where virus initiates replication; contrast, M2 increased which dampens escape facilitates delivery for lysosomal degradation. this review, we propose Achilles’ heel infection modulation pH potential eliminate invaded SARS-CoV-2; same strategy might also suitable other lethal

Язык: Английский

Процитировано

34
Airway Epithelium: A Neglected but Crucial Cell Type in Asthma Pathobiology DOI Creative Commons

Sabita Singh,

Joytri Dutta,

Archita Ray

и другие.

Diagnostics, Год журнала: 2023, Номер 13(4), С. 808 - 808

Опубликована: Фев. 20, 2023

The features of allergic asthma are believed to be mediated mostly through the Th2 immune response. In this Th2-dominant concept, airway epithelium is presented as helpless victim cytokines. However, concept inadequate fill some vital knowledge gaps in pathogenesis, like poor correlation between inflammation and remodeling severe endotypes, including Th2-low asthma, therapy resistance, etc. Since discovery type 2 innate lymphoid cells 2010, researchers started believing that played a crucial role, alarmins, which inducers ILC2, almost exclusively secreted by epithelium. This underscores eminence pathogenesis. has bipartite functionality sustaining healthy lung homeostasis asthmatic lungs. On one hand, maintains against environmental irritants/pollutants with aid its various armamentaria, chemosensory apparatus detoxification system. Alternatively, it induces an ILC2-mediated response alarmins amplify inflammatory available evidence indicates restoring epithelial health may attenuate features. Thus, we conjecture epithelium-driven pathogenesis could most current knowledge, incorporation epithelial-protective agents enhance robustness barrier combative capacity exogenous irritants/allergens mitigate incidence severity, resulting better control.

Язык: Английский

Процитировано

20