Advanced Functional Materials,
Год журнала:
2023,
Номер
34(1)
Опубликована: Сен. 15, 2023
Abstract
Methicillin‐resistant
Staphylococcus
aureus
(MRSA)
is
threatening
human
health
due
to
its
resistance
multiple
antibiotics.
Excessive
copper
(Cu)
ions
target
the
lipoylated
proteins
of
tricarboxylic
acid
cycle
cancer
cells,
inducing
proteotoxic
stress
and
their
cuproptosis
death.
Whether
plays
a
part
in
killing
MRSA
by
low‐dose
supplement
Cu
remains
be
explored.
Herein,
Cu‐doped
hydroxyapatite
nanorods
(PC)
are
prepared
on
polyetheretherketone
(PEEK)
resist
infection
improve
PEEK
performance
tissue
integration
with
assistance
near‐infrared
(NIR)
irradiation,
mechanism
against
elucidated.
Mild
photothermal
stimulation
increases
bacterial
membrane
permeability,
accelerating
ions’
intake
consequently
cuproptosis‐like
death
MRSA.
It
confirmed
aggregation
dihydrolipoamide
S‐acetyltrans‐ferase
(DLAT),
deactivation
glutathione
peroxides
4
(GPX4),
destabilization
Fe─S
cluster
ferredoxin
(FDX1)
lipoyl
synthase
(LIAS).
Fortunately,
fibroblast
behaviors
upregulated
NIR‐irradiated
PC.
In
vivo,
PC
NIR
irradiation
exhibits
outstanding
elimination,
reduced
inflammation
response,
improved
biointegration.
Overall,
it
demonstrated
that
can
induced
at
non‐cytotoxic
dose
when
cooperated
mild
heat
stimulus,
this
strategy
has
greatly
promising
application
improving
clinic.
Theranostics,
Год журнала:
2022,
Номер
13(1), С. 295 - 323
Опубликована: Дек. 19, 2022
Cancer
remains
a
severe
threat
to
human
health.
To
date,
although
various
therapeutic
methods,
including
radiotherapy
(RT),
chemotherapy,
chemodynamic
therapy
(CDT),
phototherapy,
starvation
therapy,
and
immunotherapy,
have
entered
new
stage
of
rapid
progress
in
cancer
theranostics,
their
limited
effect
significant
side
effects
need
be
considered
carefully.
With
the
development
nanotechnology,
marriage
nanomaterials
methods
provides
practical
possibility
improve
deficiencies
therapy.
Notably,
metal-organic
frameworks
(MOFs)
composed
ions/clusters
bridging
ligands
through
coordination
bonds
been
widely
applied
deal
with
drawbacks
different
such
as
effects,
low
stability,
poor
efficacy,
owing
controllable
morphologies,
tailorable
diameters,
diverse
compositions,
tunable
porosities,
high
specific
surface
areas,
facile
functionalization,
good
biocompatibility.
This
review
summarizes
recent
advanced
developments
achievements
multifunctional
MOF-based
nanoplatforms
for
single
RT,
CDT,
phototherapy
(photodynamic
photothermal
therapy),
combination
methods.
Moreover,
prospects
challenges
used
tumor
are
also
discussed.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
62(12)
Опубликована: Дек. 31, 2022
Abstract
Cuproptosis
is
a
new
form
of
programmed
cell
death
and
exhibits
enormous
potential
in
cancer
treatment.
However,
reducing
the
undesirable
Cu
ion
release
normal
tissue
maximizing
copper‐induced
therapeutic
effect
sites
are
two
main
challenges.
In
this
study,
we
constructed
photothermally
triggered
nanoplatform
(Au@MSN‐Cu/PEG/DSF)
to
realize
on‐demand
delivery
for
synergistic
therapy.
The
released
disulfiram
(DSF)
chelated
with
2+
situ
generate
highly
cytotoxic
bis(diethyldithiocarbamate)copper
(CuET),
causing
apoptosis,
formed
+
species
promoted
toxic
mitochondrial
protein
aggregation,
leading
cuproptosis.
Synergistic
photothermal
therapy,
Au@MSN‐Cu/PEG/DSF
could
effectively
kill
tumor
cells
inhibit
growth
(inhibition
rate
up
80.1
%).
These
results
provide
promising
perspective
treatment
based
on
cuproptosis,
may
also
inspire
design
advanced
nano‐therapeutic
platforms.
Journal of Materials Chemistry B,
Год журнала:
2022,
Номер
10(33), С. 6296 - 6306
Опубликована: Янв. 1, 2022
A
copper
nanomedicine
shows
the
glutathione-resistant
anticancer
effect
and
reverses
cisplatin
chemotherapy
resistance
in
non-small-cell
lung
cancer
by
cuproptosis.
Abstract
Metal‐organic
frameworks
(MOFs)
that
are
the
wonder
material
of
21st
century
consist
metal
ions/clusters
coordinated
to
organic
ligands
form
one‐
or
more‐dimensional
porous
structures
with
unprecedented
chemical
and
structural
tunability,
exceptional
thermal
stability,
ultrahigh
porosity,
a
large
surface
area,
making
them
an
ideal
candidate
for
numerous
potential
applications.
In
this
work,
recent
progress
in
design
synthetic
approaches
MOFs
explore
their
applications
fields
gas
storage
separation,
catalysis,
magnetism,
drug
delivery,
chemical/biosensing,
supercapacitors,
rechargeable
batteries
self‐powered
wearable
sensors
based
on
piezoelectric
triboelectric
nanogenerators
summarized.
Lastly,
work
identifies
present
challenges
outlines
future
opportunities
field,
which
can
provide
valuable
references.
Journal of Functional Biomaterials,
Год журнала:
2022,
Номер
13(4), С. 215 - 215
Опубликована: Ноя. 3, 2022
Bacterial
infections
pose
a
serious
threat
to
people’s
health.
Efforts
are
being
made
develop
antibacterial
agents
that
can
inhibit
bacterial
growth,
prevent
biofilm
formation,
and
kill
bacteria.
In
recent
years,
materials
based
on
metal
organic
frameworks
(MOFs)
have
attracted
significant
attention
for
various
applications
due
their
high
specific
surface
area,
enzyme-like
activity,
continuous
release
of
ions.
This
paper
reviews
the
progress
MOFs
as
agents,
focusing
preparation
methods,
fundamental
mechanisms,
strategies
enhance
effects.
Finally,
several
prospects
related
application
proposed,
aiming
provide
possible
research
directions
in
this
field.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(1)
Опубликована: Сен. 24, 2023
Copper
(Cu),
an
indispensable
trace
element
within
the
human
body,
serving
as
intrinsic
constituent
of
numerous
natural
enzymes,
carrying
out
vital
biological
functions.
Furthermore,
nanomaterials
exhibiting
enzyme-mimicking
properties,
commonly
known
nanozymes,
possess
distinct
advantages
over
their
enzyme
counterparts,
including
cost-effectiveness,
enhanced
stability,
and
adjustable
performance.
These
advantageous
attributes
have
captivated
attention
researchers,
inspiring
them
to
devise
various
Cu-based
nanomaterials,
such
copper
oxide,
Cu
metal-organic
framework,
CuS,
explore
potential
in
enzymatic
catalysis.
This
comprehensive
review
encapsulates
most
recent
advancements
illuminating
applications
realm
biochemistry.
Initially,
it
is
delved
into
emulation
typical
types
achieved
by
nanomaterials.
Subsequently,
latest
breakthroughs
concerning
nanozymes
biochemical
sensing,
bacterial
inhibition,
cancer
therapy,
neurodegenerative
diseases
treatment
discussed.
Within
this
segment,
also
explored
modulation
nanozyme
activity.
Finally,
a
visionary
outlook
for
future
development
presented.
