Low‐Dose Cu Ions Assisted by Mild Thermal Stimulus Inducing Bacterial Cuproptosis‐Like Death for Antibiosis and Biointegration DOI
Xue Yang, Lan Zhang, Jianhong Zhou

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(1)

Published: Sept. 15, 2023

Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) is threatening human health due to its resistance multiple antibiotics. Excessive copper (Cu) ions target the lipoylated proteins of tricarboxylic acid cycle cancer cells, inducing proteotoxic stress and their cuproptosis death. Whether plays a part in killing MRSA by low‐dose supplement Cu remains be explored. Herein, Cu‐doped hydroxyapatite nanorods (PC) are prepared on polyetheretherketone (PEEK) resist infection improve PEEK performance tissue integration with assistance near‐infrared (NIR) irradiation, mechanism against elucidated. Mild photothermal stimulation increases bacterial membrane permeability, accelerating ions’ intake consequently cuproptosis‐like death MRSA. It confirmed aggregation dihydrolipoamide S‐acetyltrans‐ferase (DLAT), deactivation glutathione peroxides 4 (GPX4), destabilization Fe─S cluster ferredoxin (FDX1) lipoyl synthase (LIAS). Fortunately, fibroblast behaviors upregulated NIR‐irradiated PC. In vivo, PC NIR irradiation exhibits outstanding elimination, reduced inflammation response, improved biointegration. Overall, it demonstrated that can induced at non‐cytotoxic dose when cooperated mild heat stimulus, this strategy has greatly promising application improving clinic.

Language: Английский

Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy DOI Creative Commons
Jie Yang, Dihua Dai, Xi Zhang

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 13(1), P. 295 - 323

Published: Dec. 19, 2022

Cancer remains a severe threat to human health. To date, although various therapeutic methods, including radiotherapy (RT), chemotherapy, chemodynamic therapy (CDT), phototherapy, starvation therapy, and immunotherapy, have entered new stage of rapid progress in cancer theranostics, their limited effect significant side effects need be considered carefully. With the development nanotechnology, marriage nanomaterials methods provides practical possibility improve deficiencies therapy. Notably, metal-organic frameworks (MOFs) composed ions/clusters bridging ligands through coordination bonds been widely applied deal with drawbacks different such as effects, low stability, poor efficacy, owing controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, good biocompatibility. This review summarizes recent advanced developments achievements multifunctional MOF-based nanoplatforms for single RT, CDT, phototherapy (photodynamic photothermal therapy), combination methods. Moreover, prospects challenges used tumor are also discussed.

Language: Английский

Citations

139
Photothermally Triggered Copper Payload Release for Cuproptosis‐Promoted Cancer Synergistic Therapy DOI
Jie Zhou, Qiao Yu, Juan Song

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(12)

Published: Dec. 31, 2022

Abstract Cuproptosis is a new form of programmed cell death and exhibits enormous potential in cancer treatment. However, reducing the undesirable Cu ion release normal tissue maximizing copper‐induced therapeutic effect sites are two main challenges. In this study, we constructed photothermally triggered nanoplatform (Au@MSN‐Cu/PEG/DSF) to realize on‐demand delivery for synergistic therapy. The released disulfiram (DSF) chelated with 2+ situ generate highly cytotoxic bis(diethyldithiocarbamate)copper (CuET), causing apoptosis, formed + species promoted toxic mitochondrial protein aggregation, leading cuproptosis. Synergistic photothermal therapy, Au@MSN‐Cu/PEG/DSF could effectively kill tumor cells inhibit growth (inhibition rate up 80.1 %). These results provide promising perspective treatment based on cuproptosis, may also inspire design advanced nano‐therapeutic platforms.

Language: Английский

Citations

137
Reversal of cisplatin chemotherapy resistance by glutathione-resistant copper-based nanomedicineviacuproptosis DOI
Yao Lu, Qingqing Pan, Wenxia Gao

et al.

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(33), P. 6296 - 6306

Published: Jan. 1, 2022

A copper nanomedicine shows the glutathione-resistant anticancer effect and reverses cisplatin chemotherapy resistance in non-small-cell lung cancer by cuproptosis.

Language: Английский

Citations

111
Advances and Applications of Metal‐Organic Frameworks (MOFs) in Emerging Technologies: A Comprehensive Review DOI Creative Commons
Dongxiao Li,

Anurag Yadav,

Hong Zhou

et al.

Global Challenges, Journal Year: 2023, Volume and Issue: 8(2)

Published: Dec. 30, 2023

Abstract Metal‐organic frameworks (MOFs) that are the wonder material of 21st century consist metal ions/clusters coordinated to organic ligands form one‐ or more‐dimensional porous structures with unprecedented chemical and structural tunability, exceptional thermal stability, ultrahigh porosity, a large surface area, making them an ideal candidate for numerous potential applications. In this work, recent progress in design synthetic approaches MOFs explore their applications fields gas storage separation, catalysis, magnetism, drug delivery, chemical/biosensing, supercapacitors, rechargeable batteries self‐powered wearable sensors based on piezoelectric triboelectric nanogenerators summarized. Lastly, work identifies present challenges outlines future opportunities field, which can provide valuable references.

Language: Английский

Citations

93
MOFs and MOF-Derived Materials for Antibacterial Application DOI Creative Commons
Xin Zhang, Feng Peng, Donghui Wang

et al.

Journal of Functional Biomaterials, Journal Year: 2022, Volume and Issue: 13(4), P. 215 - 215

Published: Nov. 3, 2022

Bacterial infections pose a serious threat to people’s health. Efforts are being made develop antibacterial agents that can inhibit bacterial growth, prevent biofilm formation, and kill bacteria. In recent years, materials based on metal organic frameworks (MOFs) have attracted significant attention for various applications due their high specific surface area, enzyme-like activity, continuous release of ions. This paper reviews the progress MOFs as agents, focusing preparation methods, fundamental mechanisms, strategies enhance effects. Finally, several prospects related application proposed, aiming provide possible research directions in this field.

Language: Английский

Citations

74
Gelatin/poly(vinyl alcohol)-based dual functional composite films integrated with metal-organic frameworks and anthocyanin for active and intelligent food packaging DOI
Zohreh Riahi, Ajahar Khan, Jong‐Whan Rhim

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 249, P. 126040 - 126040

Published: Aug. 2, 2023

Language: Английский

Citations

63
Metal-organic frameworks-derived layered double hydroxides: From controllable synthesis to various electrochemical energy storage/conversion applications DOI

Fateme Parsapour,

Morteza Moradi, Ashkan Bahadoran

et al.

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 313, P. 102865 - 102865

Published: Feb. 27, 2023

Language: Английский

Citations

48
The copper age in cancer treatment: From copper metabolism to cuproptosis DOI
Wensheng Xie, Zhenhu Guo,

Lingyun Zhao

et al.

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 138, P. 101145 - 101145

Published: May 23, 2023

Language: Английский

Citations

47
Gelatin/carrageenan-based smart packaging film integrated with Cu-metal organic framework for freshness monitoring and shelf-life extension of shrimp DOI
Ajahar Khan, Zohreh Riahi, Jun Tae Kim

et al.

Food Hydrocolloids, Journal Year: 2023, Volume and Issue: 145, P. 109180 - 109180

Published: Aug. 17, 2023

Language: Английский

Citations

46
Recent Development of Copper‐Based Nanozymes for Biomedical Applications DOI
Xin Yu, Yawen Wang, Jian Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 24, 2023

Copper (Cu), an indispensable trace element within the human body, serving as intrinsic constituent of numerous natural enzymes, carrying out vital biological functions. Furthermore, nanomaterials exhibiting enzyme-mimicking properties, commonly known nanozymes, possess distinct advantages over their enzyme counterparts, including cost-effectiveness, enhanced stability, and adjustable performance. These advantageous attributes have captivated attention researchers, inspiring them to devise various Cu-based nanomaterials, such copper oxide, Cu metal-organic framework, CuS, explore potential in enzymatic catalysis. This comprehensive review encapsulates most recent advancements illuminating applications realm biochemistry. Initially, it is delved into emulation typical types achieved by nanomaterials. Subsequently, latest breakthroughs concerning nanozymes biochemical sensing, bacterial inhibition, cancer therapy, neurodegenerative diseases treatment discussed. Within this segment, also explored modulation nanozyme activity. Finally, a visionary outlook for future development presented.

Language: Английский

Citations

42