Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders

ACS Chemical Neuroscience, Год журнала: 2023, Номер 14(10), С. 1717 - 1763

Опубликована: Май 8, 2023

Gut microbiota includes a vast collection of microorganisms residing within the gastrointestinal tract. It is broadly recognized that gut and brain are in constant bidirectional communication, which its metabolic production major component, form so-called microbiome–brain axis. Disturbances homeostasis caused by imbalance their functional composition activities, known as dysbiosis, cause dysregulation these pathways trigger changes blood–brain barrier permeability, thereby causing pathological malfunctions, including neurological disorders. In turn, can affect structure function through autonomic nervous system regulating motility, intestinal transit secretion, permeability. Here, we examine data from CAS Content Collection, largest published scientific information, analyze publication landscape recent research. We review advances knowledge related to human microbiome, complexity functionality, communication with central system, effect axis on mental health. discuss correlations between various diseases, specifically also explore metabolites regard impact associated diseases. Finally, assess clinical applications gut-microbiota-related substances development pipelines. hope this serve useful resource understanding current emerging field an effort further solving remaining challenges fulfilling potential.

Язык: Английский

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Akkermansia muciniphila protects the intestine from irradiation-induced injury by secretion of propionic acid

Gut Microbes, Год журнала: 2023, Номер 15(2)

Опубликована: Дек. 12, 2023

Intestinal dysbiosis frequently occurs in abdominal radiotherapy and contributes to irradiation (IR)-induced intestinal damage inflammation. Akkermansia muciniphila (A. muciniphila) is a recently characterized probiotic, which critical for maintaining the dynamics of mucus layer preserving microbiota homeostasis. However, role A. alleviation radiation enteritis remains unknown. In this study, we reported that abundance was markedly reduced intestines mice exposed IR feces patients who received radiotherapy. Abundance negatively correlated with duration diarrhea patients. Administration substantially mitigated IR-induced prevented mouse death. Analyzing metabolic products revealed propionic acid, short-chain fatty acid secreted by microbe, mediated radioprotective effect. We further demonstrated bound G-protein coupled receptor 43 (GRP43) on surface epithelia increased histone acetylation hence enhanced expression tight junction proteins occludin ZO-1 elevated level mucins, leading integrity epithelial barrier radiation-induced damage. Metformin, first-line agent treatment type II diabetes, promoted through increasing muciniphila. Together, our results plays reduction Application probiotics or their regulators, such as metformin, could be an effective protection exposure-damaged intestine.

Язык: Английский

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A Comprehensive Review of the Triangular Relationship among Diet–Gut Microbiota–Inflammation

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9366 - 9366

Опубликована: Авг. 29, 2024

The human gastrointestinal tract hosts a complex and dynamic community of microorganisms known as the gut microbiota, which play pivotal role in numerous physiological processes, including digestion, metabolism, immune function. Recent research has highlighted significant impact diet on microbiota composition functionality, consequential effects host health. Concurrently, there is growing evidence linking to inflammation, key factor many chronic diseases such inflammatory bowel disease (IBD), obesity, diabetes, cardiovascular (CVDs). This review explores how dietary components influence composition, these microbial changes affect pathways, therapeutic implications modulating this axis for prevention management. Beneficial patterns, Mediterranean (MD) plant-based diets, promote diverse balanced supporting anti-inflammatory pathways. Conversely, Western (WD), high saturated fats refined sugars, associated with dysbiosis increased inflammation. With all links between three variables considered, attempts offer thorough examination triangle formed by food.

Язык: Английский

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Innovative Applications of Bacteria and Their Derivatives in Targeted Tumor Therapy

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Despite significant progress in cancer treatment, traditional therapies still face considerable challenges, including poor targeting, severe toxic side effects, and the development of resistance. Recent advances biotechnology have revealed potential bacteria their derivatives as drug delivery systems for tumor therapy by leveraging biological properties. Engineered bacteria, Escherichia coli, Salmonella, Listeria monocytogenes, along with derivatives─outer membrane vesicles (OMVs), bacterial ghosts (BGs), spores (BSPs)─can be loaded a variety antitumor agents, enabling precise targeting sustained release within microenvironment (TME). These possess intrinsic properties that stimulate immune system, enhancing both innate adaptive responses to further amplify therapeutic effects. The ability naturally accumulate hypoxic regions versatility genetic modifications allow tailored strategies synergistically enhance effectiveness chemotherapy, immunotherapy, targeted therapies. This review comprehensively examines fundamental principles therapy, focusing on employed engineering, loading, use therapy. It also discusses challenges faced optimizing systems, such safety concerns, unintended responses, scalability clinical applications. By exploring these aspects, this provides theoretical framework improving bacterial-based contributing more effective personalized treatments.

Язык: Английский

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Gut microbiota in Alzheimer’s disease: Understanding molecular pathways and potential therapeutic perspectives

Ageing Research Reviews, Год журнала: 2025, Номер 104, С. 102659 - 102659

Опубликована: Янв. 10, 2025

Язык: Английский

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A Critical Perspective on the Supplementation of Akkermansia muciniphila: Benefits and Harms

Life, Год журнала: 2023, Номер 13(6), С. 1247 - 1247

Опубликована: Май 24, 2023

Akkermansia muciniphila is a mucin-degrading bacterium of the intestinal niche, exerting beneficial effects on host metabolic profile. Accumulating evidence indicated as promising therapeutic probiotic against disorders such obesity, type 2 diabetes and cardiovascular diseases. However, in specific microenvironments, its excessive enrichment may be not beneficial. Conditions like inflammatory bowel disease (IBD), Salmonella typhimurium infection or post-antibiotic reconstitution benefit from supplementation. Furthermore, using patients with endocrine gynecological disorders-such polycystic ovary syndrome (PCOS) endometriosis-that have higher risk developing IBD, should critically evaluated. In addition, cautionary note comes neurological field, gut microbiota suffering Parkinson's multiple sclerosis exhibits characteristic signature municiphila abundance. Overall, considering these controversial points, use evaluated an individual basis, avoiding risking unexpected effects.

Язык: Английский

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Akkermansia muciniphila Is Beneficial to a Mouse Model of Parkinson’s Disease, via Alleviated Neuroinflammation and Promoted Neurogenesis, with Involvement of SCFAs

Brain Sciences, Год журнала: 2024, Номер 14(3), С. 238 - 238

Опубликована: Фев. 29, 2024

Increasing evidence suggests that the gut microbiota may represent potential strategies for Parkinson’s disease (PD) treatment. Our previous research revealed a decreased abundance of Akkermansia muciniphila (Akk) in PD mice; however, whether Akk is beneficial to unknown. To answer this question, mice received MPTP intraperitoneally construct subacute model and were then supplemented with orally 21 consecutive days. Motor function, dopaminergic neurons, neuroinflammation, neurogenesis examined. In addition, intestinal inflammation, serum fecal short-chain fatty acids (SCFAs) analyses, assessed. We found treatment effectively inhibited reduction neurons substantia nigra pars compacta (SNpc) partially improved motor function mice. Additionally, markedly alleviated neuroinflammation striatum hippocampus promoted hippocampal neurogenesis. It also level colon inflammation. Furthermore, these aforementioned changes are mainly accompanied by alterations isovaleric acid levels, lower permeability. strongly neuroprotective agent therapy.

Язык: Английский

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Akkermansia muciniphila : A promising probiotic against inflammation and metabolic disorders

Virulence, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 27, 2024

Metabolic disease is a worldwide epidemic that has become public health problem. Gut microbiota considered to be one of the important factors maintain human by regulating host metabolism. As an abundant bacterium in gut,

Язык: Английский

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Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 14, 2025

Hepatocellular carcinoma (HCC) is the most frequently occurring type of liver tumor and considered one common primary malignant neoplasms. The prognosis for HCC dismal because its complicated etiology high level medication resistance. Immunotherapy presently regarded as effective therapeutic options HCC; nevertheless, disturbance intestinal flora, immunotherapy shows low antitumor efficacy. An increasing body research indicates that particularly Akkermansia muciniphila ( A. ), vital treatment tumors. Studies have demonstrated diminished effectiveness in cancer patients associated with a reduction levels, suggesting levels significantly enhance efficacy immunotherapy. functions gut probiotic can treat prevent wide range illnesses, including cancer. Consequently, preserving abundance enough to lower danger developing disorders. In this review, we critically evaluate current on , focus biological properties functions. different illnesses treats were then discussed, way it works This review aims give novel plan well theoretical foundation improving

Язык: Английский

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Rehydration Beverages Made from Quercus sideroxyla Infusion, Probiotics, and Prebiotics: Antioxidant and Anti-Inflammatory Potential

Foods, Год журнала: 2025, Номер 14(5), С. 837 - 837

Опубликована: Фев. 28, 2025

High rehydration beverage consumption represents a significant opportunity for the integration of biotic products that offer potential to improve body composition and intestinal health. Quercus sideroxyla (IQS) infusions contain polyphenolic compounds with antioxidant anti-inflammatory properties, in combination probiotic strains prebiotic materials, they promising alternative generating designer beverages physically active people. These were formulated using IQS, agave fructooligosaccharides (FOS), microencapsulated probiotics Akkermansia muciniphila Bifidobacterium longum, electrolytes, glucose. Stable obtained by spray drying, gums (PD > 10) gum arabic as wall materials. The formulations generated different percentages FOS (A:1.6%, B:1.2%, C:0.8%). phenolic profile was determined LC-MS/MS, indicating difference concentration compounds, highlighting changes associated addition compared IQS. Sensory analyses indicate preference highest concentration. formulations, ABTS, DPPH, ORAC, showed no differences between drinks; however, positive correlation quinic acid, t-cinnamic quercetin 3-O-glucoside, total content, suggesting synergistic effect. drinks higher content exhibited (EMA). Therefore, it can be concluded rehydrating drink offers effect activity and, according panelists, is suitable evaluating its effects on health people who have recently started physical activity.

Язык: Английский

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