Effect of Vitamin D in Long COVID Patients DOI Open Access
Ramsen Ghasan Hikmet, Christian Wejse, Jane Agergaard

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(22), С. 7058 - 7058

Опубликована: Ноя. 13, 2023

Vitamin D deficiency has been studied in the context of acute coronavirus disease 2019 (COVID-19), revealing associations with increased severity and mortality. Yet, influence vitamin on long COVID symptoms remains unknown. The purpose this study is to examine effect symptoms. Over period, 50,432 individuals within catchment area outpatient COVID-19 clinic tested positive for SARS-CoV-2 via PCR, 547 patients subsequently referred a specialized Post-COVID Clinic, 447 them enrolled study. Patient-reported paraclinical measures including were evaluated 442 patients. majority participants female (72%, n = 320/442). consumption alcohol number current smokers low. Low was observed 26% (n 115/442) patients, most commonly male (odds ratio (OR) 1.77, 95% confidence interval (CI) (1.12, 2.79), p 0.014). Additionally, low correlated younger mean age 41 years (standard deviation (SD) 12) as opposed 48 (SD 13) normal levels (OR 0.96, CI (0.94, 0.97), < 0.001). While our population indicated potentially higher prevalence insufficiency compared general population, no significant differences symptom or scores between groups. In we found association

Язык: Английский

Micronutrients at Supplemental Levels, Tight Junctions and Epithelial Barrier Function: A Narrative Review DOI Open Access

Katherine M. DiGuilio,

Elizabeth A. Del Rio,

Ronald N. Harty

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3452 - 3452

Опубликована: Март 19, 2024

Disease modifiers, whether from cancer, sepsis, systemic inflammation, or microbial pathogens, all appear to induce epithelial barrier leak, with induced changes of the Tight Junctional (TJ) complex being pivotal process. This leak-and ensuant breakdown compartmentation-plays a central role in disease morbidity on many levels. Accumulation lung water luminal compartment airways was major driver and mortality COVID-19 is an excellent example phenomenon. Increasing awareness ability micronutrients improve basal function reduce compromise pathophysiology may prove be low-cost, safe, easily administered prophylactic and/or therapeutic option amenable large populations. The growing appreciation clinical utility supplemental doses Vitamin D but one example. narrative review intended propose general theory how why micronutrients-at levels above normal dietary intake-successfully remodel TJs function. It discusses key difference between dietary/Recommended Daily Allowance (RDA) versus levels, latter are needed situations. advances hypothesis for signal transduction regulation require these higher achieve TJ remodeling other element that clinically beneficial.

Язык: Английский

Процитировано

6
The impact of supplementing vitamin D through different methods on the prognosis of COVID-19 patients: a systematic review and meta-analysis DOI Creative Commons
Xiang-Qun Zhang,

Junyuan Wu,

Hongmeng Dong

и другие.

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Сен. 25, 2024

To analyze the impact of different methods Vitamin D administration on prognosis COVID-19 patients.

Язык: Английский

Процитировано

5
The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials DOI
Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan

и другие.

Inflammopharmacology, Год журнала: 2024, Номер 32(5), С. 3205 - 3212

Опубликована: Сен. 3, 2024

Язык: Английский

Процитировано

4
The role of vitamin D in the prevention and treatment of tuberculosis: a meta-analysis of randomized controlled trials DOI
Jiahao Meng, Xi Li, Yilin Xiong

и другие.

Infection, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 29, 2024

Язык: Английский

Процитировано

4
Association Between Vitamin D and COVID-19–Related Outcomes: An Umbrella Review of Meta-Analyses DOI
Jia‐ming Yang, Ze-Qin Li,

Yanbiao Zhong

и другие.

Nutrition Reviews, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

COVID-19 remains globally pandemic, and although several meta-analyses have explored the association between vitamin D relative to clinical outcomes, a unified view has not yet emerged. To summarize evidence for associations levels COVID-19-related outcomes assess strength validity of these associations. PubMed, Embase, Web Science, Scopus, Cochrane Database Systematic Reviews databases were searched from January 1, 2020, June 15, 2024. Two reviewers independently extracted data assessed study quality. Low increased risk infection by 1.26- 2.18-fold, severe illness 1.50- 5.57-fold, intensive care unit (ICU) admission more than 2-fold, death 1.22- 4.15-fold. In addition, patients with deficiency had an average increase in length hospital stay 0.54 days compared high levels. Overall, supplementation may reduce severity (eg, ICU admissions, need mechanical ventilation) shorter but nonsignificant effect on mortality rates. there significant differences individuals testing positive those negative (mean difference [MD] = -3.22 ng mL-1; 95% CI, -5.18 -1.25), cases mild (MD -4.60 -5.49 -3.71), nonsurvivors survivors -6.59 CI: -8.94 -4.24). are associated higher rates, disease, rates among COVID-19, whereas patients' disease severity. The beneficial effects remain be further explored, however, higher-quality, randomized controlled studies. Nonetheless, caution is warranted because methodological quality most level very low. PROSPERO registration No. CRD42022385036.

Язык: Английский

Процитировано

4
Casual correlation between overweight, obesity, and severe COVID-19 infection with respiratory failure: A two-sample Mendelian randomization DOI Creative Commons
Shiqiang Chen, Qiang Zhang, Xiaobing Zhang

и другие.

Medicine, Год журнала: 2025, Номер 104(1), С. e41006 - e41006

Опубликована: Янв. 3, 2025

This study aimed to detect the causal association of overweight and obesity on severe COVID-19 infection with respiratory failure through a two-sample Mendelian randomization (MR) method based genome-wide studies datasets. All summary data exposures outcome used in this were obtained from IEU database derived Europeans. The mainly inverse variance weighted test relationship. Simultaneously, MR-PRESSO MR-EGGER pleiotropy, sensitivity analysis was performed using leave-one-out analysis. In analyses, we found no between (e.g., OR = 1.15, 95% CIs 0.96-1.37, P .13 for obesity-ebi-a-GCST90000255), subtypes 1.93, 0.90-4.14, .10 other hyperalimentation) as well (OR 0.90, 0.64-1.27, .54) failure. findings showed or Further validation is needed regarding whether risk factor it.

Язык: Английский

Процитировано

0
Long-term survival with pemetrexed-based chemotherapy in a patient with metastatic lung adenocarcinoma of unclear primary origin harboring MTHFR C677T(T/T) mutation: a case report DOI Creative Commons
Yuan Yu,

Nanjing Li,

Jin Wang

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 14

Опубликована: Янв. 21, 2025

This case report presents a patient with metastatic adenocarcinoma of unclear primary focus at initial presentation and revealed lung in subsequent follow-up. The has been surviving for more than 10 years after pemetrexed-based treatment local radiotherapy. Sequential gene tests showed kirsten rat sarcoma viral oncogene homolog (KRAS) G13D mutation epidermal growth factor receptor (EGFR) 19ins. To further investigate the correlation between pemetrexed efficacy genetic polymorphisms, genotyping on folate-metabolism-related genes [methylenetetrahydrofolate reductase (MTHFR) (C677T) MTHFR (A1298C)] were performed, revealing that exhibited T/T genotype A/A (A1298C). clinical data analysis discussed literature review to explain underlying explanation long survival.

Язык: Английский

Процитировано

0
Effect of weight loss following Roux-en-Y gastric bypass on cancer risk: A Mendelian randomization study DOI Creative Commons

Jiaming Xue,

Shuai Chen, Yu Wang

и другие.

Medicine, Год журнала: 2025, Номер 104(5), С. e41351 - e41351

Опубликована: Янв. 31, 2025

Cancer incidence and development are strongly correlated with obesity, however there is insufficient data to support a causal relationship between intentional weight loss the prevention or promotion of cancer. We investigated following Roux-en-Y gastric bypass (RYGB) 18 cancers using Mendelian randomization (MR). A genome-wide association studies (GWAS) related RYGB from GWAS catalog database were used as exposure, Medical Research Council integrative epidemiology unit open project outcomes. In order investigate exposure results, we two-sample MR approach. The primary analysis technique was inverse variance weighting, weighted median, MR-Egger regression utilized supplemental techniques confirm findings. Heterogeneity horizontal pleiotropy variety sensitivity studies, including Cochran Q test, residual sum outlier, leave-one-out analysis. included total 4 single-nucleotide polymorphisms instrumental variables through rigorous quality control screening. Under limitations Bonferroni correction threshold (P < 2.78 × 10-3), our results suggest that has significant reduced risk breast (odds ratio [OR]: 0.784; 95% confidence interval [CI]: 0.762-0.808; P = 2.167e-58) lung cancer (OR: 0.992; CI: 0.987-0.997; .0023), potential decreased hematological 0.9998462; 0.9997088-0.9999836; .028) an increased cervical 1.000123; 1.0000313-1.000215; .009). Sensitivity confirms robustness results. Genetically predicted effects in reducing It also benefits lowering hemotological increasing Considering study, reliability its underlying mechanisms require further investigation.

Язык: Английский

Процитировано

0
Epigenetic regulation in female reproduction: the impact of m6A on maternal-fetal health DOI Creative Commons
Peipei Li,

Yumeng Lin,

Hongyun Ma

и другие.

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Фев. 4, 2025

Язык: Английский

Процитировано

0
The protective effects of cheese intake on joint pain and underlying biomarkers: Insights from the Mendelian randomization DOI Creative Commons
Kaiqin Chen, Jianwu Wu, Yaolin Xu

и другие.

Journal of Dairy Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

This study aimed to investigate the relationship between cheese consumption and risk of joint pain, as well assess mediating role biomarkers. Utilizing Mendelian randomization methods, we analyzed data from UK Biobank FinnGen evaluate link intake examining 44 biomarkers potential mediators. The findings revealed a significant inverse association mediated by various biomarkers, including neutrophil count, apolipoprotein A, peak expiratory flow, cystatin C, IGF-1, sex hormone–binding globulin, urate, automated diastolic blood pressure. These results suggest that may reduce pain affecting specific providing scientific basis for dietary interventions decrease incidence pain. However, study's limitations include ethnic homogeneity sample population incomplete analysis indicating need further research confirm expand upon these initial findings.

Язык: Английский

Процитировано

0