Redox Biology,
Год журнала:
2019,
Номер
25, С. 101154 - 101154
Опубликована: Март 2, 2019
Glucose
starvation
is
one
of
the
major
forms
metabolic
stress
in
cancer
cells.
Deprivation
glucose
impairs
glycolysis
and
pentose
phosphate
pathway,
which
elicits
oxidative
due
to
enhanced
production
reactive
oxygen
species
(ROS)
impaired
antioxidant
system,
leading
redox
imbalance
cell
death.
Under
starvation,
5′
AMP-activated
protein
kinase
(AMPK)
plays
a
critical
role
maintaining
homeostasis
survival
via
multiple
pathways,
such
as
regulation
fatty
acid
metabolism
response.
Convergence
ROS
pathway
reveals
novel
molecular
targets
for
development
effective
therapeutic
strategies.
Interestingly,
AMPK,
along
with
its
upstream
liver
B1
(LKB1),
has
been
regarded
play
tumor
suppressor
role.
However,
emerging
studies
have
provided
insights
into
pro-tumor
function
LKB1-AMPK
pathway.
Therefore,
targeting
cells,
manipulation
AMPK
activity,
promising
strategy
developing
agents.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Дек. 16, 2022
Aging
is
a
gradual
and
irreversible
pathophysiological
process.
It
presents
with
declines
in
tissue
cell
functions
significant
increases
the
risks
of
various
aging-related
diseases,
including
neurodegenerative
cardiovascular
metabolic
musculoskeletal
immune
system
diseases.
Although
development
modern
medicine
has
promoted
human
health
greatly
extended
life
expectancy,
aging
society,
variety
chronic
diseases
have
gradually
become
most
important
causes
disability
death
elderly
individuals.
Current
research
on
focuses
elucidating
how
endogenous
exogenous
stresses
(such
as
genomic
instability,
telomere
dysfunction,
epigenetic
alterations,
loss
proteostasis,
compromise
autophagy,
mitochondrial
cellular
senescence,
stem
exhaustion,
altered
intercellular
communication,
deregulated
nutrient
sensing)
participate
regulation
aging.
Furthermore,
thorough
pathogenesis
to
identify
interventions
that
promote
longevity
caloric
restriction,
microbiota
transplantation,
nutritional
intervention)
clinical
treatment
methods
for
(depletion
senescent
cells,
therapy,
antioxidative
anti-inflammatory
treatments,
hormone
replacement
therapy)
could
decrease
incidence
turn
healthy
longevity.
Cancer Communications,
Год журнала:
2020,
Номер
41(2), С. 109 - 120
Опубликована: Окт. 29, 2020
Abstract
Altered
metabolism
is
a
hallmark
of
cancer,
and
the
reprogramming
energy
has
historically
been
considered
general
phenomenon
tumors.
It
well
recognized
that
long
noncoding
RNAs
(lncRNAs)
regulate
in
cancer.
However,
lncRNA‐mediated
posttranslational
modifications
metabolic
are
unclear
at
present.
In
this
review,
we
summarized
current
understanding
interactions
between
alterations
cancer‐associated
enzymes,
transcription
factors,
other
proteins
involved
pathways.
addition,
discuss
mechanisms
through
which
these
contribute
to
tumor
initiation
progression,
key
roles
clinical
significance
functional
lncRNAs.
We
believe
an
in‐depth
cancer
can
help
identify
cellular
vulnerabilities
be
exploited
for
diagnosis
therapy.
Frontiers in Endocrinology,
Год журнала:
2020,
Номер
11
Опубликована: Апрель 16, 2020
Metformin
is
a
widely
used
biguanide
drug
due
to
its
safety
and
low
cost.
It
has
been
for
over
60
years
treat
type
2
diabetes
at
the
early
stages
because
of
outstanding
ability
decrease
plasma
glucose
levels.
Over
time,
different
uses
metformin
were
discovered,
benefits
various
diseases
even
aging
verified.
These
include
cancers
(e.g.,
breast
cancer,
endometrial
bone
colorectal
melanoma),
obesity,
liver
diseases,
cardiovascular
disease,
renal
diseases.
exerts
effects
through
signaling
pathways.
However,
underlying
mechanisms
these
remain
be
elucidated.
The
aim
this
review
provide
brief
summary
discuss
possible
mechanisms.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Янв. 24, 2020
The
molecular
mechanisms
underlying
the
response
to
exercise
and
inactivity
are
not
fully
understood.
We
propose
an
innovative
approach
profile
skeletal
muscle
transcriptome
using
66
published
datasets.
Data
collected
from
human
studies
of
aerobic
resistance
exercise,
including
acute
chronic
training,
were
integrated
meta-analysis
methods
(www.metamex.eu).
Here
we
use
gene
ontology
pathway
analyses
reveal
selective
pathways
activated
by
inactivity,
versus
training.
identify
NR4A3
as
one
most
exercise-
inactivity-responsive
genes,
establish
a
role
for
this
nuclear
receptor
in
mediating
metabolic
responses
exercise-like
stimuli
vitro.
(MetaMEx)
also
highlights
differential
individuals
with
impairments.
MetaMEx
provides
extensive
dataset
transcriptional
different
modes
online
interface
readily
interrogate
database.
