Dietary regulation in health and disease

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Июль 23, 2022

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan delaying ageing various species such as yeast, drosophila, rodent, primate human. It emerges develop precision-nutrition therapeutics slow age-related biological processes treat diverse diseases. However, nutritive advantages frequently diversify among individuals well organs tissues, which brings challenges this field. In review, we summarize different forms of dietary interventions extensively prescribed improvement disease treatment pre-clinical or clinical. We discuss nutrient-mediated mechanisms including metabolic regulators, metabolism pathways, epigenetic circadian clocks. Comparably, describe diet-responsive effectors by influence endocrinic, immunological, microbial neural states responsible improving health preventing multiple diseases humans. Furthermore, expatiate patterns dietotheroapies, fasting, calorie-restricted diet, ketogenic high-fibre plants-based protein restriction diet with specific reduction amino acids microelements, potentially affecting morbid states. Altogether, emphasize profound nutritional therapy, highlight crosstalk explored critical factors individualized therapeutic approaches predictors.

Язык: Английский

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Tissue differences in the exosomal/small extracellular vesicle proteome and their potential as indicators of altered tissue metabolism

Cell Reports, Год журнала: 2022, Номер 38(3), С. 110277 - 110277

Опубликована: Янв. 1, 2022

Exosomes/small extracellular vesicles (sEVs) can serve as multifactorial mediators of cell-to-cell communication through their miRNA and protein cargo. Quantitative proteomic analysis five cell lines representing metabolically important tissues reveals that each type has a unique sEV proteome. While classical markers such CD9/CD63/CD81 vary markedly in abundance, we identify six (ENO1, GPI, HSPA5, YWHAB, CSF1R, CNTN1) are similarly abundant sEVs all types. In addition, specific markers. Using fat-specific Dicer-knockout mice with decreased white adipose tissue increased brown tissue, show these cell-type-specific predict the changing origin serum sEVs. These results provide valuable resource for understanding proteome cells metabolic homeostasis, markers, demonstrate how help predicting

Язык: Английский

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Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement

Endocrine Reviews, Год журнала: 2022, Номер 43(3), С. 441 - 468

Опубликована: Апрель 21, 2022

Abstract During the last decade, there has been great interest in elucidating biological role of extracellular vesicles (EVs), particularly, their hormone-like cell-to-cell communication. The field endocrinology is uniquely placed to provide insight into functions EVs, which are secreted from all cells fluids and carry endocrine signals engage paracellular distal interactions. EVs a heterogeneous population membrane-bound varying size, content, bioactivity. specifically packaged with signaling molecules, including lipids, proteins, nucleic acids, released via exocytosis biofluid compartments. regulate activity both proximal target cells, translational activity, metabolism, growth, development. As such, represents an integral pathway mediating intercellular Moreover, as content cell-type specific, it “fingerprint” releasing cell its metabolic status. Recently, changes profile EV bioactivity have described several endocrine-related conditions diabetes, obesity, cardiovascular diseases, cancer. goal this statement highlight relevant aspects research potential endocrinology.

Язык: Английский

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Distinct longevity mechanisms across and within species and their association with aging

Cell, Год журнала: 2023, Номер 186(13), С. 2929 - 2949.e20

Опубликована: Июнь 1, 2023

Язык: Английский

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SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis

Metabolism, Год журнала: 2023, Номер 146, С. 155657 - 155657

Опубликована: Июль 6, 2023

Язык: Английский

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