Journal of Enzyme Inhibition and Medicinal Chemistry,
Год журнала:
2024,
Номер
39(1)
Опубликована: Фев. 29, 2024
Pterostilbene
(PST)
is
a
naturally
derived
stilbene
compound
in
grapes,
blueberries,
and
other
fruits.
It
also
natural
dietary
with
wide
range
of
biological
activities
such
as
antioxidant,
anti-inflammatory,
antitumor,
so
on.
Structural
modifications
based
on
the
chemical
scaffold
pterostilbene
skeleton
are
great
importance
for
drug
discovery.
In
this
study,
skeletons
were
used
to
design
novel
anti-inflammatory
compounds
high
activity
low
toxicity.
A
total
30
new
found
synthesised,
their
safety
screened.
Among
them,
E2
was
most
active
(against
NO:
IC50
=
0.7
μM)
than
celecoxib.
Further
studies
showed
that
exerted
by
blocking
LPS-induced
NF-κB/MAPK
signalling
pathway
activation.
vivo
experiments
revealed
had
good
alleviating
effect
acute
colitis
mice.
conclusion,
may
be
promising
lead
compound.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 14, 2023
Abstract
The
ageing
process
is
a
systemic
decline
from
cellular
dysfunction
to
organ
degeneration,
with
more
predisposition
deteriorated
disorders.
Rejuvenation
refers
giving
aged
cells
or
organisms
youthful
characteristics
through
various
techniques,
such
as
reprogramming
and
epigenetic
regulation.
great
leaps
in
rejuvenation
prove
that
not
one-way
street,
many
rejuvenative
interventions
have
emerged
delay
even
reverse
the
process.
Defining
mechanism
by
which
roadblocks
signaling
inputs
influence
complex
programs
essential
for
understanding
developing
strategies.
Here,
we
discuss
intrinsic
extrinsic
factors
counteract
cell
rejuvenation,
targeted
core
mechanisms
involved
this
Then,
critically
summarize
latest
advances
state-of-art
strategies
of
rejuvenation.
Various
methods
also
provide
insights
treating
specific
ageing-related
diseases,
including
reprogramming,
removal
senescence
(SCs)
suppression
senescence-associated
secretory
phenotype
(SASP),
metabolic
manipulation,
stem
cells-associated
therapy,
dietary
restriction,
immune
heterochronic
transplantation,
etc.
potential
applications
therapy
extend
cancer
treatment.
Finally,
analyze
detail
therapeutic
opportunities
challenges
technology.
Deciphering
will
further
into
anti-ageing
disease
treatment
clinical
settings.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Март 11, 2024
Abstract
Diet,
serving
as
a
vital
source
of
nutrients,
exerts
profound
influence
on
human
health
and
disease
progression.
Recently,
dietary
interventions
have
emerged
promising
adjunctive
treatment
strategies
not
only
for
cancer
but
also
neurodegenerative
diseases,
autoimmune
cardiovascular
metabolic
disorders.
These
demonstrated
substantial
potential
in
modulating
metabolism,
trajectory,
therapeutic
responses.
Metabolic
reprogramming
is
hallmark
malignant
progression,
deeper
understanding
this
phenomenon
tumors
its
effects
immune
regulation
significant
challenge
that
impedes
eradication.
Dietary
intake,
key
environmental
factor,
can
tumor
metabolism.
Emerging
evidence
indicates
might
affect
the
nutrient
availability
tumors,
thereby
increasing
efficacy
treatments.
However,
intricate
interplay
between
pathogenesis
other
diseases
complex.
Despite
encouraging
results,
mechanisms
underlying
diet-based
remain
largely
unexplored,
often
resulting
underutilization
management.
In
review,
we
aim
to
illuminate
various
interventions,
including
calorie
restriction,
fasting-mimicking
diet,
ketogenic
protein
restriction
high-salt
high-fat
high-fiber
aforementioned
diseases.
We
explore
multifaceted
impacts
these
encompassing
their
immunomodulatory
effects,
biological
impacts,
molecular
mechanisms.
This
review
offers
valuable
insights
into
application
therapies
Cancer Cell,
Год журнала:
2023,
Номер
41(6), С. 1118 - 1133.e12
Опубликована: Июнь 1, 2023
Cyclic
GMP-AMP
synthase
(cGAS)
is
the
major
sensor
for
cytosolic
DNA
and
activates
type
I
interferon
signaling
plays
an
essential
role
in
antitumor
immunity.
However,
it
remains
unclear
whether
cGAS-mediated
activity
affected
by
nutrient
status.
Here,
our
study
reports
that
methionine
deprivation
enhances
cGAS
blocking
its
methylation,
which
catalyzed
methyltransferase
SUV39H1.
We
further
show
methylation
chromatin
sequestration
of
a
UHRF1-dependent
manner.
Blocking
immunity
suppresses
colorectal
tumorigenesis.
Clinically,
human
cancers
correlates
with
poor
prognosis.
Thus,
results
indicate
stress
promotes
activation
via
reversible
suggest
potential
therapeutic
strategy
targeting
cancer
treatment.
Experimental & Molecular Medicine,
Год журнала:
2024,
Номер
56(3), С. 495 - 500
Опубликована: Март 1, 2024
Abstract
The
intestinal
epithelium
is
the
first
line
of
defense
and
acts
as
an
interface
between
vast
microbial
world
within
gastrointestinal
tract
body’s
internal
milieu.
not
only
facilitates
nutrient
absorption
but
also
plays
a
key
role
in
defending
against
pathogens
regulating
immune
system.
Central
to
maintaining
healthy
are
stem
cells
(ISCs),
which
essential
for
replenishing
throughout
individual’s
lifespan.
Recent
research
has
unveiled
intricate
interplay
ISCs
their
niche,
includes
various
cell
types,
extracellular
components,
signaling
molecules.
In
this
review,
we
delve
into
most
recent
advances
ISC
research,
with
focus
on
roles
mucosal
homeostasis
how
functionality
influenced
by
niche
environment.
explored
regulatory
mechanisms
that
govern
behavior,
emphasizing
dynamic
adaptability
face
challenges.
Understanding
regulation
impact
aging
environmental
factors
crucial
advancing
our
knowledge
developing
translational
approaches.
Future
studies
should
investigate
interactive
effects
different
risk
function
develop
strategies
improving
regenerative
capacity
gut.
Nutrients,
Год журнала:
2022,
Номер
15(1), С. 47 - 47
Опубликована: Дек. 22, 2022
An
increasing
number
of
studies
suggest
that
diet
plays
an
important
role
in
regulating
aging
processes
and
modulates
the
development
most
age-related
diseases.The
aim
this
review
is
to
provide
overview
relationship
between
nutrition
critical
age-associated
diseases.A
literature
was
conducted
survey
recent
pre-clinical
clinical
findings
related
nutritional
factors
modulation
fundamental
cellular
molecular
mechanisms
their
prevention
genesis
diseases
aging.Studies
show
cardiovascular
cerebrovascular
diseases,
neurodegenerative
cognitive
impairment
dementia
can
be
slowed
down
or
prevented
by
certain
diets
with
anti-aging
action.
The
protective
effects
diets,
at
least
part,
may
mediated
beneficial
macro-
(protein,
fat,
carbohydrate)
micronutrient
(vitamins,
minerals)
composition.Certain
such
as
Mediterranean
diet,
play
a
significant
healthy
preventing
onset
improving
process
itself.
This
latter
strengthened
incorporating
fasting
elements
into
diet.
As
dietary
recommendations
change
age,
should
taken
consideration
well,
when
developing
tailored
needs
elderly
individuals.
Future
ongoing
on
complex
interventions
translating
results
preclinical
investigations
are
expected
lead
novel
guidelines
for
older
adults
near
future.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июль 21, 2023
Diet
may
influence
biological
aging
and
the
discrepancy
(∆age)
between
a
subject's
age
(BA)
chronological
(CA).
We
aimed
to
investigate
correlation
of
dietary
flavonoids
with
∆age
organs
(heart,
kidney,
liver)
whole
body.A
total
3193
United
States
adults
were
extracted
from
National
Health
Nutrition
Examination
Survey
(NHANES)
in
2007-2008
2017-2018.
Dietary
intake
was
assessed
using
24-h
recall
method.
Multiple
linear
regression
analysis
performed
evaluate
association
body.
BA
computed
based
on
circulating
biomarkers,
resulting
tested
as
an
outcome
analysis.The
body,
heart,
liver
inversely
associated
higher
(the
body
β
=
-
0.58,
cardiovascular
0.96,
3.19)
after
adjustment
for
variables.
However,
positively
related
renal
(β
0.40)
participants
chronic
kidney
disease
(CKD).
Associations
influenced
by
population
characteristics,
such
age,
health
behavior,
or
diseases.
Anthocyanidins,
isoflavones
flavones
had
strongest
inverse
associations
among
all
subclasses.Flavonoids
contributes
delaying
process,
especially
organ,
which
be
beneficial
reducing
long-term
risk
disease.
Military Medical Research,
Год журнала:
2023,
Номер
10(1)
Опубликована: Янв. 3, 2023
Abstract
Obesity
is
one
of
the
most
serious
global
health
problems,
with
an
incidence
that
increases
yearly
and
coincides
development
cancer.
Adipose
tissue
macrophages
(ATMs)
are
particularly
important
in
this
context
contribute
to
linking
obesity-related
inflammation
tumor
progression.
However,
functions
ATMs
on
progression
obesity-associated
cancer
remain
unclear.
In
review,
we
describe
origins,
phenotypes,
ATMs.
Subsequently,
summarize
potential
mechanisms
reprogramming
microenvironment,
including
direct
exchange
dysfunctional
metabolites,
inordinate
cytokines
other
signaling
mediators,
transfer
extracellular
vesicle
cargo,
variations
gut
microbiota
its
metabolites.
A
better
understanding
properties
under
conditions
obesity
will
lead
new
therapeutic
interventions
for
