Gut Microbiota and Cardiovascular Disease

Circulation Research, Год журнала: 2020, Номер 127(4), С. 553 - 570

Опубликована: Июль 30, 2020

Fecal microbial community changes are associated with numerous disease states, including cardiovascular (CVD). However, such data merely associative. A causal contribution for gut microbiota in CVD has been further supported by a multitude of more direct experimental evidence. Indeed, transplantation studies, specific microbiota-dependent pathways, and downstream metabolites have all shown to influence host metabolism CVD, sometimes through identified receptors. Multiple metaorganismal pathways (involving both microbe host) impact animal models show striking clinical associations human studies. For example, trimethylamine N-oxide and, recently, phenylacetylglutamine whose blood levels incident risks large-scale Importantly, link these other metabolites/pathways mechanistic model Phenylacetylglutamine, was recently promote adverse phenotypes the via interaction multiple ARs (adrenergic receptors)-a class key receptors that regulate homeostasis. In this review, we summarize recent advances microbiome research related cardiometabolic helped move field forward from associative causative results. We focus on compounds/pathways, attention paid short-chain fatty acids, secondary bile N-oxide, phenylacetylglutamine. also discuss novel therapeutic strategies directly targeting improve outcomes.

Язык: Английский

---

NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications

Gut, Год журнала: 2020, Номер 69(9), С. 1691 - 1705

Опубликована: Апрель 22, 2020

Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to third of the world's adult population. Several cohort studies have consistently documented that NAFLD (especially in its more advanced forms) associated with higher risk all-cause mortality and leading causes death among patients are cardiovascular diseases (CVDs), followed by extrahepatic malignancies liver-related complications. A growing body evidence also indicates strongly an increased major CVD events other cardiac complications (ie, cardiomyopathy, valvular calcification arrhythmias), independently traditional factors. This narrative review provides overview literature on: (1) for association between cardiovascular, arrhythmic complications, (2) putative pathophysiological mechanisms linking (3) current pharmacological treatments might benefit or adversely affect CVD.

Язык: Английский

---

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

Cellular and Molecular Immunology, Год журнала: 2021, Номер 18(4), С. 866 - 877

Опубликована: Март 11, 2021

Язык: Английский

---

Role of the gut microbiota in type 2 diabetes and related diseases

Metabolism, Год журнала: 2021, Номер 117, С. 154712 - 154712

Опубликована: Янв. 23, 2021

Язык: Английский

---

From Association to Causality: the Role of the Gut Microbiota and Its Functional Products on Host Metabolism

Molecular Cell, Год журнала: 2020, Номер 78(4), С. 584 - 596

Опубликована: Март 31, 2020

Язык: Английский

---

The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

Cell Metabolism, Год журнала: 2022, Номер 34(4), С. 581 - 594.e8

Опубликована: Март 11, 2022

Язык: Английский

---

TMAO: how gut microbiota contributes to heart failure

Translational research, Год журнала: 2020, Номер 228, С. 109 - 125

Опубликована: Авг. 22, 2020

An increasing amount of evidence reveals that the gut microbiota is involved in pathogenesis and progression various cardiovascular diseases. In patients with heart failure (HF), splanchnic hypoperfusion causes ischemia intestinal edema, allowing bacterial translocation metabolites to enter blood circulation via an impaired barrier. This results local systemic inflammatory responses. Gut microbe-derived are implicated pathology multiple diseases, including HF. These landmark findings suggest influences host's metabolic health, either directly or indirectly by producing several metabolites. this review, we mainly discuss a newly identified microbiota-dependent metabolite, trimethylamine N-oxide (TMAO), which appears participate pathologic processes HF can serve as early warning marker identify individuals who at risk disease progression. We also potential gut–TMAO–HF axis new target for treatment highlight current controversies potentially exciting directions future research.

Язык: Английский

---

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Май 13, 2023

Abstract In the past period, due to rapid development of next-generation sequencing technology, accumulating evidence has clarified complex role human microbiota in cancer and therapeutic response. More importantly, available seems indicate that modulating composition gut improve efficacy anti-cancer drugs may be feasible. However, intricate complexities exist, a deep comprehensive understanding how interacts with is critical realize its full potential treatment. The purpose this review summarize initial clues on molecular mechanisms regarding mutual effects between development, highlight relationship microbes immunotherapy, chemotherapy, radiation therapy surgery, which provide insights into formulation individualized strategies for management. addition, current emerging microbial interventions as well their clinical applications are summarized. Although many challenges remain now, great importance cannot overstated strategies, it necessary explore holistic approach incorporates modulation cancer.

Язык: Английский

---

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Redox Biology, Год журнала: 2021, Номер 46, С. 102115 - 102115

Опубликована: Авг. 25, 2021

Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity atherosclerosis. We test, whether augments angiotensin II (Ang II)-induced vasoconstriction hence promotes Ang II-induced hypertension. Plasma levels were indeed elevated hypertensive patients, thus potential pathways which mediates these effects explored. (400 ng/kg-1min-1) was chronically infused for 14 days via osmotic minipumps C57Bl/6 mice. (1%) or antibiotics given drinking water. Vasoconstriction renal afferent arterioles mesenteric arteries assessed microperfusion wire myograph, respectively. In mice, systolic blood pressure caused vasoconstriction, alleviated antibiotics. enhanced acute pressor responses (12.2 ± 1.9 versus 20.6 1.4 mmHg; P < 0.05) (32.3 2.6 55.9 7.0%, 0.001). intracellular Ca2+ release (147 7 234 26%; 0.001) mouse vascular smooth muscle cells (VSMC, 123 3 157 9%; increased treatment. Preincubation VSMC with activated PERK/ROS/CaMKII/PLCβ3 pathway. Pharmacological inhibition PERK, ROS, CaMKII PLCβ3 impaired effect on release. Thus, facilitates thereby promoting hypertension, involves axis.

Язык: Английский

---

Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites

Metabolites, Год журнала: 2021, Номер 11(12), С. 869 - 869

Опубликована: Дек. 14, 2021

Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases among women reproductive age and associated with many metabolic manifestations, such as obesity, insulin resistance (IR) hyperandrogenism. The underlying pathogenesis these symptoms has not yet been fully elucidated. With application metabolomics techniques, a variety metabolite changes have observed in serum follicular fluid (FF) PCOS patients animal models. Changes metabolites result from daily diet occur during uncommon physiological routines. However, some may provide evidence to explain possible mechanisms new approaches for prevention therapy. This article reviews relationship between pathophysiology PCOS. Furthermore, potential clinical specific will be discussed.

Язык: Английский

---