Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans

Nature Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Язык: Английский

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Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Cell, Год журнала: 2021, Номер 184(13), С. 3502 - 3518.e33

Опубликована: Май 27, 2021

Язык: Английский

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β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity

Journal of Clinical Investigation, Год журнала: 2021, Номер 132(2)

Опубликована: Ноя. 30, 2021

The dysregulation of energy homeostasis in obesity involves multihormone resistance. Although leptin and insulin resistance have been well characterized, catecholamine remains largely unexplored. Murine β3-adrenergic receptor expression adipocytes is orders magnitude higher compared with that other isoforms. While resistant to classical desensitization pathways, its mRNA (Adrb3) protein are dramatically downregulated after ligand exposure (homologous desensitization). β3-Adrenergic downregulation also occurs high-fat diet feeding, concurrent elevated inflammation. This recapitulated vitro by TNF-α treatment (heterologous Both homologous heterologous Adrb3 were triggered induction the pseudokinase TRIB1 downstream EPAC/RAP2A/PI-PLC pathway. turn degraded primary transcriptional activator Adrb3, CEBPα. EPAC/RAP inhibition enhanced catecholamine-stimulated lipolysis expenditure obese mice. Moreover, adipose tissue genes this pathway correlated body weight extremes a cohort genetically diverse mice BMI 2 independent cohorts humans. These data implicate signaling axis may explain reduced hormone-stimulated therapeutic interventions agonists.

Язык: Английский

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An update on brown adipose tissue biology: a discussion of recent findings

AJP Endocrinology and Metabolism, Год журнала: 2021, Номер 320(3), С. E488 - E495

Опубликована: Янв. 18, 2021

Brown adipose tissue (BAT) has been encouraged as a potential treatment for obesity and comorbidities due to its thermogenic activity capacity contribution energy expenditure. Some interventions such cold β-adrenergic drugs are able activate BAT thermogenesis well promote differentiation of white adipocytes into brown-like cells (browning), enhancing the these cells. In this mini-review, we discuss new mechanisms related regard, will also recent studies that have revealed existence important secretory molecules from "batokines" act in autocrine, paracrine, endocrine mechanisms, which turn may explain some beneficial roles on whole body glucose fat metabolism. Finally, insights with an additional focus distinct features metabolism between rodents humans.

Язык: Английский

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Sex Differences in Brown Adipose Tissue Function: Sex Hormones, Glucocorticoids, and Their Crosstalk

Frontiers in Endocrinology, Год журнала: 2021, Номер 12

Опубликована: Апрель 13, 2021

Excessive fat accumulation in the body causes overweight and obesity. To date, research has confirmed that there are two types of adipose tissue with opposing functions: lipid-storing white (WAT) lipid-burning brown (BAT). After rediscovery presence metabolically active BAT adults, received increasing attention especially since activation is considered a promising way to combat obesity associated comorbidities. It become clear energy homeostasis differs between sexes, which significant impact on development pathological conditions such as type 2 diabetes. Sex differences activity may contribute this and, therefore, it important address underlying mechanisms sex activity. In review, we discuss role hormones regulation under physiological some conditions. Given number studies suggesting crosstalk hypothalamic-pituitary-adrenal axis metabolism, also relation

Язык: Английский

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Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues

Cells, Год журнала: 2021, Номер 10(11), С. 3030 - 3030

Опубликована: Ноя. 5, 2021

Obesity-associated metabolic abnormalities comprise a cluster of conditions including dyslipidemia, insulin resistance, diabetes and cardiovascular diseases that has affected more than 650 million people all over the globe. Obesity results from accumulation white adipose tissues mainly due to chronic imbalance energy intake expenditure. A variety approaches treat or prevent obesity, lifestyle interventions, surgical weight loss procedures pharmacological reduce increase expenditure have failed substantially decrease prevalence obesity. Brown tissue (BAT), primary source thermogenesis in infants small mammals may represent promising therapeutic target obesity by promoting through non-shivering mediated mitochondrial uncoupling protein 1 (UCP1). Since confirmation functional BAT adult humans several groups, approximately decade ago, its association with favorable phenotype, intense interest on significance human physiology health emerged within scientific community explore potential for treatment diseases. decreased activity individuals indicates role setting On other hand, mass correlate lower body index (BMI), age glucose levels, leading incidence cardio-metabolic The increased cold exposure undetectable was associated fat sensitivity. deeper understanding interrelationship distribution deciphering proper strategies expenditure, either increasing inducing browning, holds promise possible avenues disorders.

Язык: Английский

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Modelling metabolic diseases and drug response using stem cells and organoids

Nature Reviews Endocrinology, Год журнала: 2022, Номер 18(12), С. 744 - 759

Опубликована: Сен. 7, 2022

Язык: Английский

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Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat

Molecular Metabolism, Год журнала: 2022, Номер 61, С. 101499 - 101499

Опубликована: Апрель 22, 2022

Язык: Английский

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The sympathetic nervous system in the 21st century: Neuroimmune interactions in metabolic homeostasis and obesity

Neuron, Год журнала: 2022, Номер 110(21), С. 3597 - 3626

Опубликована: Ноя. 1, 2022

Язык: Английский

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Batokines: Mediators of Inter-Tissue Communication (a Mini-Review)

Current Obesity Reports, Год журнала: 2022, Номер 11(1), С. 1 - 9

Опубликована: Янв. 7, 2022

This review highlights aspects of brown adipose tissue (BAT) communication with other organ systems and how BAT-to-tissue cross-talk could help elucidate future obesity treatments.Until recently, research on BAT has focused mainly its thermogenic activity. New identified an endocrine/paracrine function determined that many BAT-derived molecules, termed "batokines," affect the physiology a variety cell types. Batokines encompass signaling molecules including peptides, metabolites, lipids, or microRNAs. Recent studies have noted significant effects batokines as it relates whole-body metabolism cardiac function. will discuss processes liver, cardiovascular system, skeletal muscle, immune cells, white tissue. Brown crucial secretory plays key role in systemic physiology.

Язык: Английский

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