npj Biofilms and Microbiomes,
Год журнала:
2025,
Номер
11(1)
Опубликована: Март 4, 2025
Complex
molecules-mediated
interactions,
which
are
based
on
the
bidirectional
information
exchange
between
microbes
and
human
cells,
enable
defense
against
diseases
health
maintenance.
Recently,
diverse
single-direction
interactions
active
metabolites,
immunity
factors,
quorum
sensing
signals
have
largely
been
summarized
separately.
In
this
review,
according
to
a
simplified
timeline,
we
proposed
framework
of
Molecules-mediated
Bidirectional
Interactions
(MBI)
microbe
humans
decipher
understand
their
intricate
systematically.
About
microbe-derived
various
molecules,
such
as
short-chain
fatty
acids,
bile
tryptophan
catabolites,
corresponding
receptors.
Concerning
human-derived
reviewed
effect
including
hormones,
cytokines,
other
circulatory
metabolites
microbial
characteristics
phenotypes.
Finally,
discussed
challenges
trends
for
developing
deciphering
molecule-mediated
potential
applications
in
guard
health.
Abstract
Commensal
microbes
form
distinct
ecosystems
within
their
mammalian
hosts,
collectively
termed
microbiomes.
These
indigenous
microbial
communities
broadly
expand
the
genomic
and
functional
repertoire
of
host
contribute
to
formation
a
“meta‐organism.”
Importantly,
microbiomes
exert
numerous
biochemical
reactions
synthesizing
or
modifying
multiple
bioactive
small
molecules
metabolites,
which
impact
host's
physiology
in
variety
contexts.
Identifying
understanding
molecular
mechanisms
metabolite–host
interactions,
how
disrupted
signaling
can
diseases,
may
enable
therapeutic
application,
modality
“postbiotic”
therapy.
In
this
review,
we
highlight
key
examples
effects
microbe‐associated
metabolites
on
local,
systemic,
immune
environments,
discuss
these
associated
disorders.
We
outline
challenges
perspectives
potential
activity
function
plethora
microbially
as
well
possibilities
harness
them
toward
promotion
personalized
precision
interventions.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Март 16, 2023
Abstract
Background
Temozolomide
(TMZ)
is
the
preferred
chemotherapy
strategy
for
glioma
therapy.
As
a
second-generation
alkylating
agent,
TMZ
provides
superior
oral
bio-availability.
However,
limited
response
rate
(less
than
50%)
and
high
incidence
of
drug
resistance
seriously
restricts
TMZ’s
application,
there
still
lack
strategies
to
increase
sensitivity.
Methods
Luci-GL261
orthotopic
xenograft
model
combined
bioluminescence
imaging
was
utilized
evaluate
anti-tumor
effect
differentiate
sensitive
(S)/non-sensitive
(NS)
individuals.
Integrated
microbiomics
metabolomics
analysis
applied
disentangle
involvement
gut
bacteria
in
Spearman’s
correlation
test
association
between
fecal
levels
pharmacodynamics
indices.
Antibiotics
treatment
used
confirm
microbiota
response.
Flow
cytometry
analysis,
ELISA
histopathology
were
explore
potential
role
immunoregulation
mediated
Results
Firstly,
composition
significantly
altered
during
development
treatment.
Meanwhile,
vivo
anti-cancer
evaluation
suggested
remarkable
difference
efficacy
after
administration.
Moreover,
16s
rRNA
gene
sequencing
non-targeted
revealed
distinct
different
immune
infiltrating
state
non-sensitive
mice,
while
abundance
differential
related
metabolites
correlated
with
Further
verification
that
deletion
by
antibiotics
could
accelerate
development,
attenuate
inhibit
cells
(macrophage
CD8α
+
T
cell)
recruitment.
Conclusions
The
current
study
confirmed
individualized
via
immunomodulation,
hence
may
serve
as
predictive
biomarker
well
therapeutic
target
clinical
application.
Advances in Nutrition,
Год журнала:
2023,
Номер
14(4), С. 819 - 839
Опубликована: Апрель 17, 2023
Alzheimer's
disease
(AD)
is
a
neurodegenerative
characterized
by
progressive
cognitive
impairment
and
neuroinflammation.
Recent
research
has
revealed
the
crucial
role
of
gut
microbiota
microbial
metabolites
in
modulating
AD.
However,
mechanisms
which
microbiome
affect
brain
function
remain
poorly
understood.
Here,
we
review
literature
on
changes
diversity
composition
patients
with
AD
animal
models
We
also
discuss
latest
progress
understanding
pathways
from
host
or
diet
regulate
By
effects
dietary
components
function,
composition,
metabolites,
examine
potential
for
manipulation
through
intervention
to
delay
progression
Although
it
challenging
translate
our
microbiome-based
approaches
guidelines
clinical
therapies,
these
findings
provide
an
attractive
target
promoting
function.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117031 - 117031
Опубликована: Июнь 25, 2024
An
expanding
body
of
research
indicates
a
correlation
between
the
gut
microbiota
and
various
diseases.
Metabolites
produced
by
act
as
mediators
host,
interacting
with
multiple
systems
in
human
to
regulate
physiological
or
pathological
functions.
However,
further
investigation
is
still
required
elucidate
underlying
mechanisms.
One
such
metabolite
involved
choline
metabolism
microbes
trimethylamine
(TMA),
which
can
traverse
intestinal
epithelial
barrier
enter
bloodstream,
ultimately
reaching
liver
where
it
undergoes
oxidation
catalyzed
flavin-containing
monooxygenase
3
(FMO3)
form
N-oxide
(TMAO).
While
some
TMAO
eliminated
through
renal
excretion,
remaining
amounts
circulate
leading
systemic
inflammation,
endoplasmic
reticulum
(ER)
stress,
mitochondrial
disruption
normal
functions
humans.
As
representative
microbial
originating
from
gut,
has
significant
potential
both
biomarker
for
monitoring
disease
occurrence
progression
tailoring
personalized
treatment
strategies
patients.
This
review
provides
an
extensive
overview
sources
its
blood,
well
impact
on
several
major
Additionally,
we
explore
latest
areas
related
along
future
directions.
