npj Biofilms and Microbiomes,
Год журнала:
2025,
Номер
11(1)
Опубликована: Март 4, 2025
Complex
molecules-mediated
interactions,
which
are
based
on
the
bidirectional
information
exchange
between
microbes
and
human
cells,
enable
defense
against
diseases
health
maintenance.
Recently,
diverse
single-direction
interactions
active
metabolites,
immunity
factors,
quorum
sensing
signals
have
largely
been
summarized
separately.
In
this
review,
according
to
a
simplified
timeline,
we
proposed
framework
of
Molecules-mediated
Bidirectional
Interactions
(MBI)
microbe
humans
decipher
understand
their
intricate
systematically.
About
microbe-derived
various
molecules,
such
as
short-chain
fatty
acids,
bile
tryptophan
catabolites,
corresponding
receptors.
Concerning
human-derived
reviewed
effect
including
hormones,
cytokines,
other
circulatory
metabolites
microbial
characteristics
phenotypes.
Finally,
discussed
challenges
trends
for
developing
deciphering
molecule-mediated
potential
applications
in
guard
health.
Journal of Chemical Information and Modeling,
Год журнала:
2025,
Номер
65(1), С. 201 - 213
Опубликована: Янв. 2, 2025
The
design
of
drugs
and
nutraceutics
that
mimic
microbial
metabolites
is
an
emerging
drug
modality
in
medicinal
chemistry
attempts
to
modulate
the
myriad
interactions
these
molecules
establish
with
host
proteins.
Understanding
how
interact
their
target
proteins
key
perform
a
rational
metabolite
mimetic
for
therapeutic
usage.
In
present
work,
we
address
this
question
by
analyzing
functional
groups
they
display
set
more
than
71K
protein–metabolite
from
PDB.
Significant
differences
group
distributions,
chemical
features,
co-occurrences
are
observed
distinct
subsets
molecules.
same
true
distributions
interaction
types.
By
correlating
both
data
sets,
able
explain
patterns
terms
patterns.
These
results
will
shed
light
on
novel
purposes.
Pharmacological Research,
Год журнала:
2023,
Номер
189, С. 106690 - 106690
Опубликована: Фев. 8, 2023
The
gut
microbiome
is
closely
shaped
by
host
genetic
and
dietary
factors
to
regulate
metabolic
health
disease.
However,
the
signaling
mechanisms
underlying
such
interactions
have
been
largely
unclear.
Here
we
identify
G
protein-coupled
receptor
35
(Gpr35)
as
a
regulator
of
microbial
ecology
susceptibility
obesity
hepatic
steatosis
in
mice.
Both
global
intestinal
epithelia
specific
ablation
Gpr35
aggravated
high-fat
diet
(HFD)-induced
disturbance
deficiency
induced
remarkable
loss
goblet
cells
an
extensive
remodeling
microbiome,
featuring
enrichment
Bacteroides
Ruminococcus
genera.
Antibiotics
treatment
co-housing
alleviated
markers
deficient
Spatiotemporal
profiling
mono-colonization
screening
revealed
that
gnavus
synergized
with
HFD
promote
possibly
via
tryptophan
phenylalanine
pathway
metabolites.
Our
results
provide
mechanistic
insights
into
genetic-diet-microbe
interplay
dictates
disorder.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 31, 2025
Gasdermin
E
(GSDME)
is
a
pyroptotic
cell
death
effector
and
promising
target
for
tissue
injury.
Here
we
perform
high-throughput
screening
demonstrate
that
methylcobalamin
(MeCbl),
an
endogenous
coenzyme
form
of
vitamin
B12,
specific
GSDME
inhibitor
highly
effective
against
cholestatic
liver
failure.
MeCbl
specifically
blocks
cleavage
by
directly
binding
with
GSDME.
In
cholestasis-,
cisplatin-
or
concanavalin
A
(Con
A)-induced
male
mouse
models,
significantly
suppresses
transaminase
activities
inflammation,
alleviates
hepatocyte
death,
reduces
mortality
mice
blocking
cleavage.
The
conserved
Cys180
residue
in
essential
caspase-3/GzmB
recognition.
base-off
conformation
coordinates
to
prevent
caspase-3/GzmB-GSDME
interactions
thereby
GSDME-mediated
pyroptosis.
summary,
our
study
discovers
as
promisingly
be
developed
drug
failure,
other
triggered
sterile
inflammation
and/or
organ
Cardiovascular
diseases
(CVDs)
continue
to
be
a
significant
contributor
global
mortality,
imposing
substantial
burden
and
emphasizing
the
urgent
need
for
disease
control
save
lives
prevent
disability.
With
advancements
in
technology
scientific
research,
novel
mechanisms
underlying
CVDs
have
been
uncovered,
leading
exploration
of
promising
treatment
targets
aimed
at
reducing
disease.
One
most
intriguing
findings
is
relationship
between
gut
microbiota,
challenging
traditional
understanding
introducing
concept
gut-heart
axis.
The
through
changes
microbial
compositions
functions,
plays
crucial
role
influencing
local
systemic
effects
on
host
physiology
development,
with
its
metabolites
acting
as
key
regulators.
In
previous
studies,
we
emphasized
importance
specific
such
betaine,
putrescine,
trimethylamine
oxide,
International Journal of Biological Sciences,
Год журнала:
2023,
Номер
19(12), С. 3869 - 3891
Опубликована: Янв. 1, 2023
Aortic
aneurysm
and
dissection
(AAD)
are
a
group
of
insidious
lethal
cardiovascular
diseases
that
characterized
by
seriously
threatening
the
life
health
people,
but
lack
effective
nonsurgical
interventions.
Alterations
in
metabolites
increasingly
recognized
as
universal
features
AAD
because
metabolic
abnormalities
have
been
identified
not
only
arterial
tissue
also
blood
vascular
cells
from
both
patients
animal
models
with
this
disease.
Over
past
few
decades,
studies
further
supported
notion
linking
to
various
types
such
those
derived
gut
microbiota
or
involved
TCA
cycle
lipid
metabolism.
Many
these
altered
may
contribute
pathogenesis
AAD.
This
review
aims
illustrate
close
association
between
body
metabolism
occurrence
development
AAD,
well
summarize
significance
correlated
pathological
process
provides
valuable
insight
for
developing
new
therapeutic
agents
Therefore,
we
present
brief
overview
biology,
including
signaling
pathways
processes
current
clinical
targeting
metabolisms.
It
is
necessary
understand
mechanisms
underlying
significant
knowledge
diagnosis
therapeutics
treatment.
FEMS Microbiology Reviews,
Год журнала:
2024,
Номер
48(6)
Опубликована: Ноя. 1, 2024
Abstract
Microbes
compete
and
cooperate
with
each
other
via
a
variety
of
chemicals
circuits.
Recently,
to
decipher,
simulate,
or
reconstruct
microbial
communities,
many
researches
have
been
engaged
in
engineering
microbiomes
bottom-up
synthetic
biology
approaches
for
diverse
applications.
However,
they
separately
focused
on
individual
perspectives
including
genetic
circuits,
communications
tools,
microbiome
engineering,
promising
The
strategies
coordinating
ecosystems
based
different
regulation
circuits
not
systematically
summarized,
which
calls
more
comprehensive
framework
the
assembly
communities.
In
this
review,
we
summarize
cross-talk
orthogonal
modules
de
novo
assembling
functional
ecosystems,
thus
promoting
further
consortia-based
First,
review
communication-based
regulations
among
various
communities
from
intra-species
inter-species
aspects.
Then,
are
summarized
at
metabolites,
transcription,
translation,
post-translation
levels,
respectively.
Furthermore,
give
details
better
design
optimize
propose
design-build-test-learn
procedure
function
specification,
chassis
selection,
interaction
design,
system
build,
performance
test,
modeling
analysis,
global
optimization.
Finally,
current
challenges
opportunities
discussed
development
application
ecosystems.
