Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics

Journal of Hematology & Oncology, Год журнала: 2023, Номер 16(1)

Опубликована: Сен. 12, 2023

Abstract Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen nutrients, tumor cells undergo transformations exploit various ways acquiring lipid increasing oxidation. addition, stromal immune the microenvironment also reprogramming, which further affects functional phenotypes responses. Given metabolism plays a critical role supporting cancer progression remodeling microenvironment, targeting pathway could provide novel approach treatment. This review seeks to: (1) clarify overall landscape mechanisms cancer, (2) summarize landscapes within their roles progression, (3) potential therapeutic targets for metabolism, highlight combining such approaches with other anti-tumor therapies new opportunities patients.

Язык: Английский

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Harnessing innate immune pathways for therapeutic advancement in cancer

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Март 25, 2024

Abstract The innate immune pathway is receiving increasing attention in cancer therapy. This ubiquitous across various cell types, not only cells but also adaptive cells, tumor and stromal cells. Agonists targeting the have shown profound changes microenvironment (TME) improved prognosis preclinical studies. However, to date, clinical success of drugs remains limited. Interestingly, recent studies that activation can paradoxically promote progression. uncertainty surrounding therapeutic effectiveness targeted for a critical issue needs immediate investigation. In this review, we observe role demonstrates heterogeneity, linked development stage, status, specific types. We propose within TME, exhibits multidimensional diversity. diversity fundamentally rooted cellular heterogeneity manifested as variety signaling networks. pro-tumor effect essentially reflects suppression classical pathways potential alternative pathways. Refining our understanding tumor’s network employing appropriate strategies enhance ability harness anti-tumor ultimately bridge gap from application.

Язык: Английский

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Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer

Cancer Cell, Год журнала: 2024, Номер 42(5), С. 869 - 884.e9

Опубликована: Апрель 4, 2024

Язык: Английский

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Breast cancer: pathogenesis and treatments

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 18, 2025

Abstract Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes malignancy-related deaths in women. The increasingly nuanced molecular subtypes breast cancer have enhanced comprehension precision treatment this disease. mechanisms tumorigenesis progression been central to scientific research, with investigations spanning various perspectives such as tumor stemness, intra-tumoral microbiota, circadian rhythms. Technological advancements, particularly those integrated artificial intelligence, significantly improved accuracy detection diagnosis. emergence novel therapeutic concepts drugs represents a paradigm shift towards personalized medicine. Evidence suggests that optimal diagnosis models tailored individual patient risk expected are crucial, supporting era oncology for cancer. Despite rapid advancements increasing emphasis on clinical comprehensive update summary panoramic knowledge related disease needed. In review, we provide thorough overview global status including its epidemiology, factors, pathophysiology, subtyping. Additionally, elaborate latest research into contributing progression, emerging strategies, long-term management. This review offers valuable insights Cancer Research, thereby facilitating future progress both basic application.

Язык: Английский

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Reprogramming of lipid metabolism in the tumor microenvironment: a strategy for tumor immunotherapy

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Фев. 1, 2024

Abstract Lipid metabolism in cancer cells has garnered increasing attention recent decades. Cancer thrive hypoxic conditions, nutrient deficiency, and oxidative stress cannot be separated from alterations lipid metabolism. Therefore, exhibit increased metabolism, uptake, lipogenesis storage to adapt a progressively challenging environment, which contribute their rapid growth. Lipids aid cell activation. absorb lipids with the help of transporter translocase proteins obtain energy. Abnormal levels series synthases over-accumulation tumor microenvironment (TME). reprogramming plays an essential role TME. are closely linked several immune phenotypic transformation. The further promotes immunosuppression, leads escape. This event significantly affects progression, treatment, recurrence, metastasis cancer. present review describes TME examines connection between immunotherapy.

Язык: Английский

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Metabolic reprogramming and immune evasion: the interplay in the tumor microenvironment

Biomarker Research, Год журнала: 2024, Номер 12(1)

Опубликована: Сен. 3, 2024

Abstract Tumor cells possess complex immune evasion mechanisms to evade system attacks, primarily through metabolic reprogramming, which significantly alters the tumor microenvironment (TME) modulate cell functions. When a is sufficiently immunogenic, it can activate cytotoxic T-cells target and destroy it. However, tumors adapt by manipulating their pathways, particularly glucose, amino acid, lipid metabolism, create an immunosuppressive TME that promotes escape. These alterations impact function differentiation of non-tumor within TME, such as inhibiting effector T-cell activity while expanding regulatory myeloid-derived suppressor cells. Additionally, these changes lead imbalance in cytokine chemokine secretion, further enhancing landscape. Emerging research increasingly focusing on roles evaluating how reprogrammed metabolism influence functional ultimately aid evasion. Despite our incomplete understanding intricate interactions between cells, connection elements presents significant challenges for cancer immunotherapy. This review highlights altered providing new insights could facilitate development novel immunotherapies.

Язык: Английский

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Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 9, 2025

Metabolic reprogramming within the tumor microenvironment (TME) is a hallmark of cancer and crucial determinant progression. Research indicates that various metabolic regulators form network in TME interact with immune cells, coordinating response. dysregulation creates an immunosuppressive TME, impairing antitumor In this review, we discuss how affect cell crosstalk TME. We also summarize recent clinical trials involving challenges metabolism-based therapies translation. word, our review distills key regulatory factors their mechanisms action from complex metabolism, identified as regulators. These provide theoretical basis research direction for development new strategies targets therapy based on reprogramming. Refining Depicting between stromal cells during Emphasizing unresolved translation advantages personalized treatment. Providing support therapies.

Язык: Английский

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Extracellular vesicles and particles as mediators of long-range communication in cancer: connecting biological function to clinical applications

Extracellular Vesicles and Circulating Nucleic Acids, Год журнала: 2023, Номер 4(3), С. 461 - 485

Опубликована: Янв. 1, 2023

Over the past decade, extracellular vesicles and particles (EVPs) have emerged as critical mediators of intercellular communication, participating in numerous physiological pathological processes. In context cancer, EVPs exert local effects, such increased invasiveness, motility, reprogramming tumor stroma, well systemic including pre-metastatic niche formation, determining organotropism, promoting metastasis altering homeostasis various organs systems, liver, muscle, circulatory system. This review provides an overview advances EVP research during highlighting heterogeneity EVPs, their roles cancer progression, metastasis. Moreover, clinical potential useful biomarkers therapeutic agents is explored. Last but not least, progress analysis technologies that facilitated these discoveries discussed, which may further propel future.

Язык: Английский

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Pre-metastatic niche: from revealing the molecular and cellular mechanisms to the clinical applications in breast cancer metastasis

Theranostics, Год журнала: 2023, Номер 13(7), С. 2301 - 2318

Опубликована: Янв. 1, 2023

Breast cancer (BC) is one of the most commonly diagnosed cancers and leading cause cancer-related deaths in women worldwide.Metastasis a major contributor to high mortality usually endpoint series sequential dynamic events.One critical events forming pre-metastatic niche (PMN) that occurs before macroscopic tumor cell invasion provides suitable environment for cells colonize progress into metastases.Due unique characteristics PMN metastasis, developing therapies target may bring new advantages preventing metastasis at an early stage.Various biological molecules, cells, signaling pathways are altered BC, regulating functions distinctive immune stromal remodeling, inducing angiogenesis, effect metabolic reprogramming organotropism promote formation.In this review, we elucidate multifaceted mechanisms contributing development discuss PMN, highlight significance providing potential diagnostic therapeutic strategies BC which promising insights foundations future studies.

Язык: Английский

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Hypoxia preconditioning of adipose stem cell-derived exosomes loaded in gelatin methacryloyl (GelMA) promote type H angiogenesis and osteoporotic fracture repair

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Март 15, 2024

Abstract The challenges posed by delayed atrophic healing and nonunion stand as formidable obstacles in osteoporotic fracture treatment. processes of type H angiogenesis osteogenesis emerge pivotal mechanisms during bone regeneration. Notably, the preconditioning adipose-derived stem cell (ADSC) exosomes under hypoxic conditions has garnered attention for its potential to augment secretion functionality these exosomes. In present investigation, we embarked upon a comprehensive elucidation underlying hypo-ADSC-Exos within milieu Our findings revealed that harboured preeminent miRNA, namely, miR-21-5p, which emerged principal orchestrator angiogenic effects. Through vitro experiments, demonstrated capacity stimulate proliferation, migration, human umbilical vein endothelial cells (HUVECs) via mediation miR-21-5p. inhibition miR-21-5p effectively attenuated proangiogenic effects mediated hypo-ADSC-Exos. Mechanistically, our investigation exosomal emanating from hypo-ADSCs exerts regulatory influence targeting sprouly1 (SPRY1) HUVECs, thereby facilitating activation PI3K/AKT signalling pathway. knockdown SPRY1 HUVECs was found potentiate and, concomitantly, HUVEC angiogenesis. culminating stage study involved compelling vivo demonstration wherein GelMA loaded with validated substantially enhance local concomitant This enhancement unequivocally attributed modulation SPRY1. summary, offers pioneering perspective on utility readily available Graphical

Язык: Английский

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