Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 7, 2025
The
cGAS-STING
signaling
pathway
serves
as
a
critical
link
between
DNA
sensing
and
innate
immunity,
has
tremendous
potential
to
improve
anti-tumor
immunity
by
generating
type
I
interferons.
However,
STING
agonists
have
shown
decreasing
biotherapeutic
efficacy
in
clinical
trials.
Tumor
metabolism,
characterized
aberrant
nutrient
utilization
energy
production,
is
fundamental
hallmark
of
tumorigenesis.
And
modulating
metabolic
pathways
tumor
cells
been
discovered
therapeutic
strategy
for
tumors.
As
research
concerning
progressed,
emerging
evidence
highlights
its
role
reprogramming,
independent
immune
function,
indicating
targets
activation
cancers.
In
this
review,
we
delve
into
the
interplay
multiple
pathways.
We
also
synthesize
current
knowledge
on
antitumor
functions
STING,
within
microenvironment
(TME)
that
could
be
exploited
activation.
This
review
necessity
future
dissect
complex
interactions
with
various
cancer
types,
emphasizing
personalized
strategies
based
profiling.
Immunity,
Год журнала:
2024,
Номер
57(5), С. 941 - 956
Опубликована: Май 1, 2024
Ferroptosis
is
a
type
of
regulated
cell
death
that
drives
the
pathophysiology
many
diseases.
Oxidative
stress
detectable
in
types
death,
but
only
ferroptosis
involves
lipid
peroxidation
and
iron
dependency.
originates
propagates
from
several
organelles,
including
mitochondria,
endoplasmic
reticulum,
Golgi,
lysosomes.
Recent
data
have
revealed
immune
cells
can
both
induce
undergo
ferroptosis.
A
mechanistic
understanding
how
regulates
immunity
critical
to
controls
responses
this
dysregulated
disease.
Translationally,
more
work
needed
produce
ferroptosis-modulating
immunotherapeutics.
This
review
focuses
on
role
immune-related
diseases,
infection,
autoimmune
cancer.
We
discuss
immunity,
regulation
contributes
disease
pathogenesis,
targeting
may
lead
novel
therapies.
Annual Review of Immunology,
Год журнала:
2024,
Номер
42(1), С. 521 - 550
Опубликована: Фев. 21, 2024
Immune
checkpoint
blockade
(ICB)
induces
a
remarkable
and
durable
response
in
subset
of
cancer
patients.
However,
most
patients
exhibit
either
primary
or
acquired
resistance
to
ICB.
This
arises
from
complex
interplay
diverse
dynamic
mechanisms
within
the
tumor
microenvironment
(TME).
These
include
genetic,
epigenetic,
metabolic
alterations
that
prevent
T
cell
trafficking
site,
induce
immune
dysfunction,
interfere
with
antigen
presentation,
drive
heightened
expression
coinhibitory
molecules,
promote
survival
after
attack.
The
TME
worsens
ICB
through
formation
immunosuppressive
networks
via
inhibition,
regulatory
metabolites,
abnormal
resource
consumption.
Finally,
patient
lifestyle
factors,
including
obesity
microbiome
composition,
influence
resistance.
Understanding
heterogeneity
cellular,
molecular,
environmental
factors
contributing
is
crucial
develop
targeted
therapeutic
interventions
enhance
clinical
response.
comprehensive
overview
highlights
key
may
be
clinically
translatable.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(14)
Опубликована: Фев. 14, 2024
Immunotherapy
faces
insufficient
immune
activation
and
limited
effectiveness.
Herein,
we
report
a
smart
DNA
hydrogel
that
enables
the
release
of
multivalent
functional
units
at
tumor
site
to
enhance
efficacy
immunotherapy.
The
was
assembled
from
two
types
ultra-long
chains
synthesized
via
rolling
circle
amplification.
One
chain
contained
adjuvant
CpG
oligonucleotides
polyaptamers
for
loading
natural
killer
cell-derived
exosomes;
other
G-quadruplex
photodynamic
agents.
formed
through
base-pairing.
HhaI
restriction
endonuclease
sites
were
designed
between
units.
Upon
stimuli
in
sites,
effectively
cleaved
by
released
disassembled
into
Natural
exosomes
played
an
anti-tumor
role,
oligonucleotide
activated
antigen-presenting
cells
Besides
tumor-killing
effect
therapy,
generated
cellular
debris
acted
as
antigen
further
immunotherapeutic
effect.
In
mouse
melanoma
orthotopic
model,
localized
therapeutic
agent,
achieved
remarkable
suppression
rate
91.2
%.
exhibited
enhanced
synergistic
immunotherapy
expanding
application
materials
biomedicine.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(10)
Опубликована: Янв. 3, 2024
Abstract
Platinum
complexes
are
potential
antitumor
drugs
in
chemotherapy.
Their
impact
on
tumor
treatment
could
be
greatly
strengthened
by
combining
with
immunotherapy.
Increasing
evidences
indicate
that
the
activity
of
platinum
is
not
limited
to
chemical
killing
effects,
but
also
extends
immunomodulatory
actions.
This
review
introduced
general
concept
chemoimmunotherapy
and
summarized
progress
as
chemoimmunotherapeutic
agents
recent
years.
developed
into
inducers
immunogenic
cell
death,
blockers
immune
checkpoint,
regulators
signaling
pathway,
modulators
microenvironment,
etc.
The
synergy
between
chemotherapeutic
effects
reinforces
complexes,
helps
them
circumvent
drug
resistance
systemic
toxicity.
exploration
for
may
create
new
opportunities
revive
discovery
metal
anticancer
drugs.
Metabolic
alterations,
a
hallmark
of
cancer,
enable
tumor
cells
to
adapt
their
environment
by
modulating
glucose,
lipid,
and
amino
acid
metabolism,
which
fuels
rapid
growth
contributes
treatment
resistance.
In
primary
breast
metabolic
shifts
such
as
the
Warburg
effect
enhanced
lipid
synthesis
are
closely
linked
chemotherapy
failure.
Similarly,
metastatic
lesions
often
display
distinct
profiles
that
not
only
sustain
but
also
confer
resistance
targeted
therapies
immunotherapies.
The
review
emphasizes
two
major
aspects:
mechanisms
driving
in
both
how
unique
environments
sites
further
complicate
treatment.
By
targeting
vulnerabilities
at
stages,
new
strategies
could
improve
efficacy
existing
provide
better
outcomes
for
cancer
patients.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(8)
Опубликована: Авг. 1, 2024
Abstract
Pancreatic
cancer
is
an
aggressive
with
a
poor
prognosis.
Metabolic
abnormalities
are
one
of
the
hallmarks
pancreatic
cancer,
and
cells
can
adapt
to
biosynthesis,
energy
intake,
redox
needs
through
metabolic
reprogramming
tolerate
nutrient
deficiency
hypoxic
microenvironments.
use
glucose,
amino
acids,
lipids
as
maintain
malignant
growth.
Moreover,
they
also
metabolically
interact
in
tumour
microenvironment
change
cell
fate,
promote
progression,
even
affect
immune
responses.
Importantly,
changes
at
body
level
deserve
more
attention.
Basic
research
clinical
trials
based
on
targeted
therapy
or
combination
other
treatments
full
swing.
A
comprehensive
in-depth
understanding
regulation
will
not
only
enrich
mechanisms
disease
progression
but
provide
inspiration
for
new
diagnostic
therapeutic
approaches.
