Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(38), С. 20959 - 20973
Опубликована: Сен. 16, 2024
Obesity-related
metabolic
diseases
are
associated
with
a
chronic
inflammatory
state.
Calenduloside
E
(CE)
is
triterpene
saponin
from
sugar
beet.
In
mouse
models,
CE
reduced
pro-inflammatory
cytokines
in
white
adipose
tissue
(WAT)
and
decreased
macrophage
infiltration
of
WAT.
And
inhibited
pyroptosis
J774A.1
cells
WAT
by
inhibiting
the
activation
nucleotide-binding
oligomerization
domain,
leucine-rich
repeat
pyrin
domain-containing
3
(NLRP3)
inflammasome.
Moreover,
could
trigger
Sirtuin
2
(SIRT2),
leading
to
decrease
acetylation
NLRP3,
particularly
at
K24
site.
addition,
it
has
been
shown
that
can
reduce
inflammation
adipocytes
have
induced
macrophage-conditioned
medium.
However,
selective
SIRT2
inhibitor
AGK2
hindered
beneficial
effects
CE.
summary,
capacity
impede
NLRP3-mediated
triggering
activity,
thus
positioning
as
promising
therapeutic
avenue
for
combating
obesity-related
disorders.
The Lancet Healthy Longevity,
Год журнала:
2024,
Номер
5(5), С. e314 - e325
Опубликована: Апрель 5, 2024
Time-restricted
eating
(TRE)
has
been
suggested
to
be
a
simple,
feasible,
and
effective
dietary
strategy
for
individuals
with
overweight
or
obesity.
We
aimed
investigate
the
effects
of
3
months
10-h
per-day
TRE
follow-up
on
bodyweight
cardiometabolic
risk
factors
in
at
high
type
2
diabetes.
Nutrition & Dietetics,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 2, 2025
Abstract
Aims
Adherence
to
any
dietary
approach
is
crucial
for
achieving
long‐term
benefits.
This
qualitative
study
aims
explore
the
facilitators
and
barriers
adherence,
how
individuals
in
community
settings
navigate
time‐restricted
eating
their
daily
lives.
Methods
Semi‐structured,
in‐depth
interviews
were
conducted
with
21
participants
who
had
practised
(confining
window
<10h
a
day;
excluding
periodic
fasting
methods
like
5:2
or
alternate
day
fasting)
periods
ranging
from
3
months
more
than
5
years.
A
content
analysis,
underpinned
by
Capability‐Opportunity‐Motivation‐Behaviour
Model,
identified
multiple
facilitators,
barriers,
strategies
that
evolved
over
practice.
Results
Key
included
simplicity
versatility
of
eating,
maintaining
non‐obsessive
non‐dieting
mindset,
having
supportive
environment.
Barriers
hunger
food
cravings,
an
obsessive
mindset
during
initial
stages,
conflicting
schedules
social
occasions,
including
holidays.
Participants
employed
several
coping
successfully
adherence
reported
confidence
as
lifestyle
contributes
better
health
weight
management.
Conclusion
Our
findings
suggest
successful
implementation
requires
flexibility
viewing
it
short‐term
loss
tool.
Guidelines
are
needed
help
practitioners
implement
practices
promote
healthier
behaviours.
Nutrients,
Год журнала:
2024,
Номер
16(5), С. 722 - 722
Опубликована: Март 1, 2024
Background:
The
concept
of
time-restricted
eating
(TRE)
or
feeding
(TRF)
promotes
daily
periods
and
fasting
to
determine
whole-body
physiology.
Chronic
misalignment
circadian
rhythms
chrono-disruption
is
related
an
increased
risk
diverse
metabolic
disorders.
progression
non-communicable
diseases
seems
be
affected
by
the
timing
meals.
As
a
result,
intermittent
promising
approach
for
their
management.
aim
present
literature
review
examine
scrutinize
TRE
protocols
in
fields
prevention
management
Methods:
This
thorough
reported
associations
among
rhythm,
disorders,
diabetes
mellitus,
obesity,
TRE,
TRF,
dietary
habits,
disruption,
cardiovascular
diseases,
atherosclerosis,
non-alcoholic
fatty
liver
find
already
existing
clinical
studies
from
last
decade
(2014–2024)
most
precise
scientific
online
databases,
using
relevant
specific
keywords.
Several
inclusion
exclusion
criteria
were
applied
only
longitudinal,
cross-sectional,
descriptive,
prospective
human
studies.
Results:
currently
available
findings
remain
scarce
suggest
that
chrononutrition
behaviors
such
as
TRF
may
promote
several
benefits,
mainly
body
weight
control
fat
loss.
Improvements
glucose
levels
lipid
profiles
are
quite
controversial
since
some
show
little
no
effect.
far
concerned,
efficacy
stronger
disease
due
decline
Conclusions:
Even
if
there
has
been
gradual
increase
few
years,
providing
perspectives,
currently,
conclusive
evidence
role
Future
should
well-designed
with
longer
duration
larger
sample
sizes.
Moreover,
it
important
best
window
its
feasibility.
Abstract
The
circadian
clock
is
an
evolutionarily
conserved
time-keeper
that
regulates
physiological
processes
across
24
h.
In
the
cardiovascular
system,
several
parameters,
such
as
blood
pressure,
heart
rate,
and
metabolism,
exhibit
time-of-day
variations.
These
features
are
in
part
driven
by
clock.
Chronic
perturbation
of
diurnal
rhythmicity
due
to
shift
work
or
irregular
social
schedules
has
been
associated
with
increased
risk
hypertension,
arrhythmias,
myocardial
infarction.
This
review
discusses
impact
rhythms
on
human
health
effect
disruption
occurrence
adverse
cardiac
events.
Additionally,
we
discuss
how
main
factors
diseases,
obesity,
sleep
disorders,
aging,
affect
rhythms.
Finally,
elaborate
chronotherapy
well
targeting
highlight
novel
approaches
translate
our
scientific
understanding
into
clinical
practice.
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1721 - 1721
Опубликована: Май 31, 2024
Chrono-nutrition
(meal
timing)
aligns
food
consumption
with
one’s
circadian
rhythm.
The
first
meal
(e.g.,
breakfast)
likely
promotes
synchronization
of
peripheral
clocks,
thereby
supporting
metabolic
health.
Time-restricted
feeding
(TRF)
has
been
shown
to
reduce
body
weight
(BW)
and/or
improve
cardiovascular
biomarkers.
In
this
explorative
literature
assessment,
13
TRF
randomized
controlled
trials
(RCTs)
were
selected
from
PubMed
and
Scopus
evaluate
the
effects
early
(eTRF:
before
10:30
a.m.)
late
(lTRF:
after
11:30
on
parameters
Although
distinct
variations
in
study
design
evident
between
reports,
consistently
decreased
energy
intake
(EI)
BW,
improved
insulin
resistance
as
well
systolic
blood
pressure.
eTRF
seemed
have
a
greater
beneficial
effect
than
lTRF
(HOMA-IR).
Importantly,
most
studies
did
not
appear
consider
chronotype
their
evaluation,
which
may
underestimated
effects.
intervention
be
promising
approach
for
risk
reduction
human
diseases.
To
conclusively
determine
benefits
identify
clear
differences
lTRF,
future
should
longer-term
(≥8
weeks)
well-defined
(differences
in)
windows,
include
participants
chronotypically
matching
intervention,
compare
outcomes
those
control
groups
without
any
dietary
limitations.
