Redox-responsive self-assembled peptide hydrogel for mitochondrial-targeted anticancer drug delivery
Applied Materials Today,
Год журнала:
2024,
Номер
41, С. 102471 - 102471
Опубликована: Окт. 13, 2024
Язык: Английский
Homologous-adhering/targeting cell membrane- and cell-mediated delivery systems: a cancer-catch-cancer strategy in cancer therapy
Regenerative Biomaterials,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 20, 2024
Abstract
Low
tumor
enrichment
remains
a
serious
and
urgent
problem
for
drug
delivery
in
cancer
therapy.
Accurate
targeting
of
sites
is
still
critical
aim
Though
there
have
been
variety
strategies
to
improve
the
enrichment,
biological
barriers
cause
most
delivered
guests
fail
or
be
excreted
before
they
work.
Recently,
cell
membrane-based
systems
attracted
huge
amount
attention
due
their
advantages
such
as
easy
access,
good
biocompatibility
immune
escape,
which
contribute
biomimetic
structures
specific
surface
proteins.
Furthermore,
are
referred
homologous-targeting
function
exhibit
significantly
high
adhesion
internalization
homologous-type
cells
even
though
exact
mechanism
not
entirely
revealed.
Here,
we
summarize
sources
characterizations
membrane
systems,
including
reconstructed
single
hybrid
nano-/microcarriers,
well
engineered
cells.
Additionally,
advanced
applications
these
therapy
categorized
summarized
according
components
membranes.
The
potential
factors
related
homologous
also
discussed.
By
discussing
applications,
challenges
opportunities,
expect
far-reaching
development
preclinic
clinics.
Язык: Английский
Nanomaterial-based detection of circulating tumor cells and circulating cancer stem cells for cancer immunotherapy
Nano Convergence,
Год журнала:
2024,
Номер
11(1)
Опубликована: Дек. 13, 2024
Abstract
Nanomaterials
have
emerged
as
transformative
tools
for
detecting
circulating
tumor
cells
(CTCs)
and
cancer
stem
(CCSCs),
significantly
enhancing
diagnostics
immunotherapy.
Nanomaterials,
including
those
composed
of
gold,
magnetic
materials,
silica,
enhanced
the
sensitivity,
specificity,
efficiency
isolating
these
rare
from
blood.
These
developments
are
paramount
importance
early
detection
providing
real-time
insights
into
metastasis
treatment
resistance,
which
essential
development
personalized
immunotherapies.
The
combination
nanomaterial-based
platforms
with
phenotyping
techniques,
such
Raman
spectroscopy
microfluidics,
enables
researchers
to
enhance
immunotherapy
protocols
targeting
specific
CTC
CCSC
markers.
also
facilitate
targeted
delivery
immunotherapeutic
agents,
immune
checkpoint
inhibitors
therapeutic
antibodies,
directly
cells.
This
synergistic
approach
has
potential
efficacy
mitigate
risk
relapse.
In
conclusion,
this
review
critically
examines
use
nanomaterial-driven
systems
CTCs
CCSCs,
their
application
in
immunotherapy,
suggests
future
directions,
highlighting
transform
integration
treatment,
thereby
paving
way
more
precise
therapies.
Graphical
Язык: Английский