Redox-responsive self-assembled peptide hydrogel for mitochondrial-targeted anticancer drug delivery

Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102471 - 102471

Published: Oct. 13, 2024

Language: Английский

Homologous-adhering/targeting cell membrane- and cell-mediated delivery systems: a cancer-catch-cancer strategy in cancer therapy

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 20, 2024

Abstract Low tumor enrichment remains a serious and urgent problem for drug delivery in cancer therapy. Accurate targeting of sites is still critical aim Though there have been variety strategies to improve the enrichment, biological barriers cause most delivered guests fail or be excreted before they work. Recently, cell membrane-based systems attracted huge amount attention due their advantages such as easy access, good biocompatibility immune escape, which contribute biomimetic structures specific surface proteins. Furthermore, are referred homologous-targeting function exhibit significantly high adhesion internalization homologous-type cells even though exact mechanism not entirely revealed. Here, we summarize sources characterizations membrane systems, including reconstructed single hybrid nano-/microcarriers, well engineered cells. Additionally, advanced applications these therapy categorized summarized according components membranes. The potential factors related homologous also discussed. By discussing applications, challenges opportunities, expect far-reaching development preclinic clinics.

Language: Английский

Nanomaterial-based detection of circulating tumor cells and circulating cancer stem cells for cancer immunotherapy

Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)

Published: Dec. 13, 2024

Abstract Nanomaterials have emerged as transformative tools for detecting circulating tumor cells (CTCs) and cancer stem (CCSCs), significantly enhancing diagnostics immunotherapy. Nanomaterials, including those composed of gold, magnetic materials, silica, enhanced the sensitivity, specificity, efficiency isolating these rare from blood. These developments are paramount importance early detection providing real-time insights into metastasis treatment resistance, which essential development personalized immunotherapies. The combination nanomaterial-based platforms with phenotyping techniques, such Raman spectroscopy microfluidics, enables researchers to enhance immunotherapy protocols targeting specific CTC CCSC markers. also facilitate targeted delivery immunotherapeutic agents, immune checkpoint inhibitors therapeutic antibodies, directly cells. This synergistic approach has potential efficacy mitigate risk relapse. In conclusion, this review critically examines use nanomaterial-driven systems CTCs CCSCs, their application in immunotherapy, suggests future directions, highlighting transform integration treatment, thereby paving way more precise therapies. Graphical

Language: Английский