Current Organic Chemistry,
Год журнала:
2024,
Номер
28(9), С. 725 - 732
Опубликована: Апрель 17, 2024
Abstract:
Organocatalyst
1,4-diazabicyclo
[2.2.2]octane
(DABCO)
has
proven
to
be
an
efficient
and
environmentally
friendly
catalyst
in
the
multicomponent
reaction
involving
aldehydes,
ethylenediamine,
thioglycolic
acid
under
microwave
conditions.
DABCO
stands
out
among
other
organic
catalysts
due
its
cost-effectiveness,
non-toxic
nature,
conscious
profile.
The
method
employed
this
study
exhibited
exceptional
attributes,
such
as
high
yields,
swift
times,
atom
economy,
reusability,
minimal
loading.
Additionally,
there
were
excellent
yields
of
products
(90-94%).
melting
points,
UV-Vis,
IR,
1HNMR,
13CNMR,
used
analyze
produced
compounds.
invitro
antibacterial
activity
synthesized
compounds
was
investigated
against
pathogenic
strains
E.
coli
Bacillus
supstalis,
results
obtained
further
explained
with
help
DFT
molecular
orbital
calculations.
Moreover,
compound
4b
found
most
potent
agent
amongst
all
tested
Chemical Reviews,
Год журнала:
2024,
Номер
124(9), С. 5227 - 5420
Опубликована: Апрель 25, 2024
Ionic
liquids
(ILs)
have
unique
physicochemical
properties
that
make
them
advantageous
for
catalysis,
such
as
low
vapor
pressure,
non-flammability,
high
thermal
and
chemical
stabilities,
the
ability
to
enhance
activity
stability
of
(bio)catalysts.
ILs
can
improve
efficiency,
selectivity,
sustainability
bio(transformations)
by
acting
activators
enzymes,
selectively
dissolving
substrates
products,
reducing
toxicity.
They
also
be
recycled
reused
multiple
times
without
losing
their
effectiveness.
based
on
imidazolium
cation
are
preferred
structural
organization
aspects,
with
a
semiorganized
layer
surrounding
catalyst.
act
container,
providing
confined
space
allows
modulation
electronic
geometric
effects,
miscibility
reactants
residence
time
species.
stabilize
ionic
radical
species
control
catalytic
dynamic
processes.
Supported
IL
phase
(SILP)
derivatives
polymeric
(PILs)
good
options
molecular
engineering
greener
The
major
factors
governing
metal,
photo-,
electro-,
biocatalysts
in
discussed
detail
vast
literature
available
over
past
two
half
decades.
Catalytic
reactions,
ranging
from
hydrogenation
cross-coupling
oxidations,
promoted
homogeneous
heterogeneous
catalysts
both
single
multiphase
conditions,
extensively
reviewed
considering
knowledge
accumulated
until
now.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(7), С. 6581 - 6581
Опубликована: Апрель 1, 2023
Multicomponent
reactions
(MCRs)
have
emerged
as
a
powerful
strategy
in
synthetic
organic
chemistry
due
to
their
widespread
applications
drug
discovery
and
development.
MCRs
are
flexible
transformations
which
three
or
more
substrates
react
form
structurally
complex
products
with
high
atomic
efficiency.
They
being
increasingly
appreciated
highly
exploratory
evolutionary
tool
by
the
medicinal
community,
opening
door
sustainable,
cost-effective
rapid
synthesis
of
biologically
active
molecules.
In
recent
years,
MCR-based
strategies
found
extensive
application
field
discovery,
several
anticancer
drugs
been
synthesized
through
MCRs.
this
review,
we
present
an
overview
representative
literature
examples
documenting
different
approaches
development
new
drugs.
Applied Organometallic Chemistry,
Год журнала:
2023,
Номер
37(5)
Опубликована: Март 15, 2023
The
discovery
of
a
new
class
heterocyclic
compounds
by
Pietro
Biginelli
in
1891
was
regarded
as
watershed
point
the
history
chemistry.
is
well‐known
organic
chemistry
technique
for
generating
dihydropyrimidones/thiones,
which
are
important
biological
compounds.
motifs
has
been
studied
drug
development
because
extensive
use
multiple
adducts
various
domains.
current
review
focuses
on
magnetic
reusable
iron
nanocatalysts,
imparting
their
catalytic
role
reaction,
can
be
impregnated
with
ionic
liquids,
Lewis's
acids,
metal
(monometallic
or
bimetallic),
hybrid
polymers
catalyst
support.
Our
ongoing
interest
developing
environmentally
friendly
synthetic
methodologies
prompted
us
to
investigate
utility
magnetically
catalysts
where
workup
provides
an
eco‐friendly
approach
comparison
traditional
methods
provide
clear
understanding
pathways
leading
formation
adducts.
Abstract
The
sonochemical‐assisted
multicomponent
reaction
catalyzed
by
ionic
liquid,
solvent‐free
synthesis,
improving
chemical
structure,
computational
calculations,
and
nonlinear
optical
properties
(NLO)
assessment
of
a
new
amidoalkyl
naphthol
derivative
4
,
that
is,
[
N
‐((2‐hydroxynaphthalen‐1‐yl)(4‐nitrophenyl)methyl)‐2‐phenylhydrazinecarbothioamide
(C
24
H
20
O
3
S),
are
introduced.
corrected
structure
the
synthesized
is
confirmed
different
spectroscopic
techniques
viz.,
(
1
13
C)
NMR,
Infrared
radiation
(IR),
Mass
spectra,
UV‐vis.
spectra.
To
obtain
geometrical
confirm
experimental
findings,
DFT‐assisted
B3LYP/6‐31G*
method
used.
NLO
studied
using
two
visible
laser
beams
where
its
refraction
index
(NLRI)
at
473
nm
cw
beam
obtained
diffraction
patterns
(DPs)
Z‐scan
techniques.
As
high
as
5.312×10
−11
m
2
/W
NLRI
obtained.
all‐optical
switching
(AOS)
which
usually
carried
out
utilizing
beams,
controlling
controlled,
generalized
use
three
controlling,
controlled
532
635
beams.
