Synlett,
Journal Year:
2023,
Volume and Issue:
35(14), P. 1648 - 1668
Published: Oct. 30, 2023
Abstract
Heterocycles
have
gained
recognition
as
vital
components
in
approved
drugs,
drawing
substantial
attention
from
the
scientific
community.
Ionic
liquids
(ILs)
been
utilized
for
their
transformative
roles
heterocycle
synthesis,
showcasing
distinctive
properties
that
are
pivotal
diverse
chemical
transformations,
while
also
acting
effective
catalysts
and
offering
safer
alternatives
to
volatile
organic
solvents.
This
account
delves
into
synthesis
of
nitrogen-
oxygen-containing
heterocyclic
structures,
employing
various
ILs
such
ammonium,
cholinium,
DABCO-based,
DBU-based,
guanidinium-based,
imidazolium,
phosphonium,
pyridinium,
other
miscellaneous
examples.
They
proven
indispensable
facilitating
reactions
like
Fischer
indole
Biginelli
reaction,
Knoevenagel
condensations
many
more.
Notably,
recyclability
serves
a
valuable
asset,
aiding
completion
intricate
synthetic
pathways,
multicomponent
reactions,
one-pot
syntheses,
ultimately
enhancing
yields.
account,
covering
literature
published
2022,
seeks
guide
researchers
selecting
suitable
specific
enable
aza-
and/or
oxa-heterocycles.
The
described
advancements
represent
promising
prospects
drug
development
applications
within
domain
chemistry.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6581 - 6581
Published: April 1, 2023
Multicomponent
reactions
(MCRs)
have
emerged
as
a
powerful
strategy
in
synthetic
organic
chemistry
due
to
their
widespread
applications
drug
discovery
and
development.
MCRs
are
flexible
transformations
which
three
or
more
substrates
react
form
structurally
complex
products
with
high
atomic
efficiency.
They
being
increasingly
appreciated
highly
exploratory
evolutionary
tool
by
the
medicinal
community,
opening
door
sustainable,
cost-effective
rapid
synthesis
of
biologically
active
molecules.
In
recent
years,
MCR-based
strategies
found
extensive
application
field
discovery,
several
anticancer
drugs
been
synthesized
through
MCRs.
this
review,
we
present
an
overview
representative
literature
examples
documenting
different
approaches
development
new
drugs.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(9), P. 5227 - 5420
Published: April 25, 2024
Ionic
liquids
(ILs)
have
unique
physicochemical
properties
that
make
them
advantageous
for
catalysis,
such
as
low
vapor
pressure,
non-flammability,
high
thermal
and
chemical
stabilities,
the
ability
to
enhance
activity
stability
of
(bio)catalysts.
ILs
can
improve
efficiency,
selectivity,
sustainability
bio(transformations)
by
acting
activators
enzymes,
selectively
dissolving
substrates
products,
reducing
toxicity.
They
also
be
recycled
reused
multiple
times
without
losing
their
effectiveness.
based
on
imidazolium
cation
are
preferred
structural
organization
aspects,
with
a
semiorganized
layer
surrounding
catalyst.
act
container,
providing
confined
space
allows
modulation
electronic
geometric
effects,
miscibility
reactants
residence
time
species.
stabilize
ionic
radical
species
control
catalytic
dynamic
processes.
Supported
IL
phase
(SILP)
derivatives
polymeric
(PILs)
good
options
molecular
engineering
greener
The
major
factors
governing
metal,
photo-,
electro-,
biocatalysts
in
discussed
detail
vast
literature
available
over
past
two
half
decades.
Catalytic
reactions,
ranging
from
hydrogenation
cross-coupling
oxidations,
promoted
homogeneous
heterogeneous
catalysts
both
single
multiphase
conditions,
extensively
reviewed
considering
knowledge
accumulated
until
now.
Applied Organometallic Chemistry,
Journal Year:
2023,
Volume and Issue:
37(5)
Published: March 15, 2023
The
discovery
of
a
new
class
heterocyclic
compounds
by
Pietro
Biginelli
in
1891
was
regarded
as
watershed
point
the
history
chemistry.
is
well‐known
organic
chemistry
technique
for
generating
dihydropyrimidones/thiones,
which
are
important
biological
compounds.
motifs
has
been
studied
drug
development
because
extensive
use
multiple
adducts
various
domains.
current
review
focuses
on
magnetic
reusable
iron
nanocatalysts,
imparting
their
catalytic
role
reaction,
can
be
impregnated
with
ionic
liquids,
Lewis's
acids,
metal
(monometallic
or
bimetallic),
hybrid
polymers
catalyst
support.
Our
ongoing
interest
developing
environmentally
friendly
synthetic
methodologies
prompted
us
to
investigate
utility
magnetically
catalysts
where
workup
provides
an
eco‐friendly
approach
comparison
traditional
methods
provide
clear
understanding
pathways
leading
formation
adducts.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(7)
Published: Feb. 13, 2024
Abstract
The
sonochemical‐assisted
multicomponent
reaction
catalyzed
by
ionic
liquid,
solvent‐free
synthesis,
improving
chemical
structure,
computational
calculations,
and
nonlinear
optical
properties
(NLO)
assessment
of
a
new
amidoalkyl
naphthol
derivative
4
,
that
is,
[
N
‐((2‐hydroxynaphthalen‐1‐yl)(4‐nitrophenyl)methyl)‐2‐phenylhydrazinecarbothioamide
(C
24
H
20
O
3
S),
are
introduced.
corrected
structure
the
synthesized
is
confirmed
different
spectroscopic
techniques
viz.,
(
1
13
C)
NMR,
Infrared
radiation
(IR),
Mass
spectra,
UV‐vis.
spectra.
To
obtain
geometrical
confirm
experimental
findings,
DFT‐assisted
B3LYP/6‐31G*
method
used.
NLO
studied
using
two
visible
laser
beams
where
its
refraction
index
(NLRI)
at
473
nm
cw
beam
obtained
diffraction
patterns
(DPs)
Z‐scan
techniques.
As
high
as
5.312×10
−11
m
2
/W
NLRI
obtained.
all‐optical
switching
(AOS)
which
usually
carried
out
utilizing
beams,
controlling
controlled,
generalized
use
three
controlling,
controlled
532
635
beams.
