Asian Journal of Pharmaceutical Sciences,
Год журнала:
2023,
Номер
18(5), С. 100852 - 100852
Опубликована: Сен. 1, 2023
How
to
effectively
transform
the
pro-oncogenic
tumor
microenvironments
(TME)
surrounding
a
into
an
anti-tumoral
never
fails
attract
people
study.
Small
interfering
RNA
(siRNA)
is
considered
one
of
most
noteworthy
research
directions
that
can
regulate
gene
expression
following
process
known
as
interference
(RNAi).
The
about
siRNA
delivery
targeting
cells
and
TME
has
been
on
rise
in
recent
years.
Using
drugs
silence
critical
proteins
was
efficient
solutions.
However,
manufacture
system
faces
three
major
obstacles,
i.e.,
appropriate
cargo
protection,
accurately
targeted
delivery,
site-specific
release.
In
review,
we
summarized
pharmacological
actions
remolding
TME.
addition,
strategies
combination
therapy
with
remodel
are
thoroughly
discussed.
meanwhile,
advancements
development
all
clinically
investigated
commercialized
technologies
also
presented.
Ultimately,
propose
nanoparticle
drug
may
be
future
focus
oncogene
therapy.
This
summary
offers
thorough
analysis
roadmap
for
general
readers
working
field.
ACS Applied Nano Materials,
Год журнала:
2023,
Номер
6(9), С. 7123 - 7149
Опубликована: Апрель 25, 2023
Since
cancer
has
a
very
complex
pathophysiology,
existing
treatment
strategies
encounter
several
challenges
such
as
the
lack
of
specificity/selectivity,
induction
multidrug
resistance,
and
possible
side
effects/toxicity.
A
wide
variety
organic,
inorganic,
hybrid
nanosystems
have
been
designed
with
unique
magnetic,
thermal,
mechanical,
electrical,
optical
properties
for
targeted
therapy.
These
advanced
enhanced
bioavailability,
biocompatibility,
drug
loading
capacity
developed
therapy
to
reduce
toxicity
improve
targeting
properties.
In
this
context,
persist
their
clinical
translational
studies
enhancement
therapeutic
efficiency
well
optimization
synthesis
conditions
large-scale
production.
addition,
despite
promising
preclinical
results,
number
available
patients
is
still
low,
partly
due
understanding
differences
among
animal
model
species
humans
that
influence
behavior
functionality
these
nanosystems.
Regarding
this,
organ-on-a-chip
platforms
can
significantly
help
in
screening
delivery
aspects
cancer/tumor
cells
modeling
research;
organs-on-chip
approach
also
be
helpful
analyze
cancer–immune
interactions.
Future
should
focus
on
exploration
multifunctional
synergistic
chemo-photothermal,
photothermal/photodynamic,
immunotherapeutic
potentials
smart
theranostic
capabilities.
Herein,
recent
advancements
pertaining
applications
therapeutics
are
deliberated.
Current
obstacles
limitations
hindering
application
from
research
uses
discussed
while
providing
recommendations
more
efficient
adoption
nanomaterials
cancers.
International Journal of Pharmaceutics X,
Год журнала:
2024,
Номер
8, С. 100281 - 100281
Опубликована: Авг. 28, 2024
Cancer
is
the
leading
cause
of
death
globally,
and
conventional
treatments
have
limited
efficacy
with
severe
side
effects.
The
use
nanotechnology
has
potential
to
reduce
effects
drugs
by
creating
efficient
controlled
anticancer
drug
delivery
systems.
Nanoparticles
(NPs)
used
as
carriers
offer
several
advantages,
including
enhanced
protection,
biodistribution,
selectivity
and,
pharmacokinetics.
Therefore,
this
review
devoted
various
organic
(lipid,
polymeric)
well
inorganic
nanoparticles
based
on
different
building
units
providing
a
wide
range
potent
Within
these
nanoparticulate
systems,
chitosan
(CS)-based
NPs
are
discussed
particular
emphasis
due
unique
properties
CS
its
derivatives
non-toxicity,
biodegradability,
mucoadhesivity,
tunable
physico-chemical
biological
allowing
their
alteration
specifically
target
cancer
cells.
In
context
streamlining
systems
(DDS),
innovative
nanoplatform-based
therapy
pathways
involving
passive
active
targeting
stimuli-responsive
DDS
enhancing
overall
orthogonality
developed
NP-DDS
towards
included.
most
up-to-date
information
delivering
anti-cancer
using
modern
dosage
forms
specifically,
CSNPs,
summarised
evaluated
concerning
benefits,
limitations,
advanced
applications.
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2022,
Номер
34(3), С. 398 - 418
Опубликована: Сен. 9, 2022
CRISPR/Cas
mediated
gene-editing
has
opened
new
avenues
for
therapies
that
show
great
potential
treating
or
curing
cancers,
genetic
disorders,
and
microbial
infections
such
as
HIV.
CRISPR/Cas9
tool
is
highly
efficacious
in
revolutionizing
the
advent
of
genome
editing;
however,
its
efficient
safe
delivery
a
major
hurdle
due
to
cellular
impermeability
instability.
Nano
vectors
could
be
explored
scale
up
effective
CRISPR/Cas9.
This
review
highlights
importance
editing
system
cancer
treatment
along
with
effect
lipid-based
nanoparticles
cells.
The
solid-lipid
nanoparticles,
nanostructured
lipid
carrier,
niosomes
have
shown
CRISPR
compounds
design
application
therapy
been
discussed
future
concern
prospects
nanoparticle
based
focused
toward
end.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2023,
Номер
18(5), С. 100852 - 100852
Опубликована: Сен. 1, 2023
How
to
effectively
transform
the
pro-oncogenic
tumor
microenvironments
(TME)
surrounding
a
into
an
anti-tumoral
never
fails
attract
people
study.
Small
interfering
RNA
(siRNA)
is
considered
one
of
most
noteworthy
research
directions
that
can
regulate
gene
expression
following
process
known
as
interference
(RNAi).
The
about
siRNA
delivery
targeting
cells
and
TME
has
been
on
rise
in
recent
years.
Using
drugs
silence
critical
proteins
was
efficient
solutions.
However,
manufacture
system
faces
three
major
obstacles,
i.e.,
appropriate
cargo
protection,
accurately
targeted
delivery,
site-specific
release.
In
review,
we
summarized
pharmacological
actions
remolding
TME.
addition,
strategies
combination
therapy
with
remodel
are
thoroughly
discussed.
meanwhile,
advancements
development
all
clinically
investigated
commercialized
technologies
also
presented.
Ultimately,
propose
nanoparticle
drug
may
be
future
focus
oncogene
therapy.
This
summary
offers
thorough
analysis
roadmap
for
general
readers
working
field.
