AAPS PharmSciTech, Год журнала: 2024, Номер 25(6)
Опубликована: Июль 24, 2024
Язык: Английский
Drug Resistance Updates, Год журнала: 2022, Номер 65, С. 100889 - 100889
Опубликована: Ноя. 10, 2022
Язык: Английский
Процитировано
42
International Journal of Pharmaceutics, Год журнала: 2023, Номер 638, С. 122938 - 122938
Опубликована: Апрель 8, 2023
Язык: Английский
Процитировано
34
International Journal of Pharmaceutics, Год журнала: 2023, Номер 637, С. 122894 - 122894
Опубликована: Март 28, 2023
Язык: Английский
Процитировано
26
Materials Today Communications, Год журнала: 2023, Номер 36, С. 106424 - 106424
Опубликована: Июнь 12, 2023
Язык: Английский
Процитировано
26
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2165 - 2165
Опубликована: Фев. 10, 2024
The incidence of skin cancer continues to grow. There are an estimated 1.5 million new cases each year, which nearly 350,000 melanoma, is often fatal. Treatment challenging and ineffective, with conventional chemotherapy playing a limited role in this context. These disadvantages can be overcome by the use nanoparticles may allow for early detection monitoring neoplastic changes determining effectiveness treatment. This article briefly reviews present understanding characteristics cancers, their epidemiology, risk factors. It also outlines possibilities using nanotechnology, especially nanoparticles, transport medicinal substances. Research over previous decade on carriers active substances indicates that drugs delivered more accurately tumor site, resulting higher therapeutic efficacy. describes application liposomes, carbon nanotubes, metal polymer existing therapies. discusses challenges encountered nanoparticle therapy improving performance. Undoubtedly, promising method help fight against cancer.
Язык: Английский
Процитировано
13
Nano-Micro Letters, Год журнала: 2024, Номер 16(1)
Опубликована: Май 2, 2024
As a new form of regulated cell death, ferroptosis has unraveled the unsolicited theory intrinsic apoptosis resistance by cancer cells. The molecular mechanism depends on induction oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage structural integrity Due their high loading tunability, nanocarriers can escort delivery ferro-therapeutics desired site enhanced permeation or retention effect active targeting. This review shed light necessity iron in growth fascinating features regulating cycle metastasis. Additionally, we discussed ferroptosis-mediated therapy using nanoplatforms chemical basis overcoming barriers therapy.
Язык: Английский
Процитировано
11
Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1197 - 1197
Опубликована: Сен. 11, 2024
The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system is a gene-editing technology. Nanoparticle delivery systems have attracted attention because of the limitations conventional viral vectors. In this review, we assess efficiency various nanoparticles, including lipid-based, polymer-based, inorganic, and extracellular vesicle-based systems, as non-viral vectors for CRISPR/Cas9 delivery. We discuss their advantages, limitations, current challenges. By summarizing recent advancements highlighting key strategies, review aims to provide comprehensive overview role in advancing technology clinical applications gene therapy.
Язык: Английский
Процитировано
10
Biomaterials, Год журнала: 2022, Номер 291, С. 121876 - 121876
Опубликована: Окт. 28, 2022
Язык: Английский
Процитировано
33
Colloids and Surfaces B Biointerfaces, Год журнала: 2023, Номер 225, С. 113231 - 113231
Опубликована: Фев. 28, 2023
Язык: Английский
Процитировано
19
Beni-Suef University Journal of Basic and Applied Sciences, Год журнала: 2024, Номер 13(1)
Опубликована: Окт. 23, 2024
Abstract Background Nanoparticle-mediated drug delivery aims to target specific cells, addressing the challenge that many drugs lack necessary properties reach their intended targets effectively. Lipid-based nanocarriers considered as a promising due biocompatibility and ability encapsulate various drugs. Surface modifications, including attachment of polyethylene glycol for stability conjugation targeting ligands (e.g., antibodies, peptides) delivery, play crucial role in enhancing interaction these with biological environments. These modifications improve cellular uptake targeted thereby increasing therapeutic efficacy reducing side effects. This review will explore surface modification techniques impact on performance lipid delivery. Main body nanodelivery platforms have garnered significant interest notable characteristics, accommodate high loads, reduced toxicity, improved bioavailability, compatibility systems, within gastrointestinal environment, controlled release capabilities, streamlined scaling up processes, simplified validation procedures. Targeted lipid-based represent advancement over non-targeted counterparts cancer therapy. Unlike which distribute indiscriminately throughout body, can be engineered or antibodies specifically recognize bind tumor-associated markers, enabling precise cells. approach enhances while minimizing adverse effects healthy tissues, offering strategy improving outcomes treatment. Conclusion The authors this provide an overview preclinical research diverse nanocarriers, such liposomes, solid polymer hybrid nanoparticles. customization carriers using modifiers is discussed, folic Acid, peptides, polysaccharides, transferrin, antibodies. Surface-modified offer regulated discharge, penetration capability, conveyance. work compiles recent instances emerging surface-modified nanocarrier systems applications, sourced from existing literature. Novel approaches engineering aimed at specificity were discussed. Key advancements field, mechanisms demonstrated studies, highlighted. Additionally, critical gaps require attention include long-term stability, biocompatibility, scalable production methods, regulatory challenges, steps transition bench bedside. Graphical abstract
Язык: Английский
Процитировано
9