Design and characterization of adipose-derived mesenchymal stem cell loaded alginate/pullulan/hyaluronic acid hydrogel scaffold for wound healing applications

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 241, С. 124556 - 124556

Опубликована: Апрель 23, 2023

Язык: Английский

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Injectable hydrogel for sustained delivery of progranulin derivative Atsttrin in treating diabetic fracture healing

Biomaterials, Год журнала: 2023, Номер 301, С. 122289 - 122289

Опубликована: Авг. 24, 2023

Язык: Английский

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Turmeric Herb Extract-Incorporated Biopolymer Dressings with Beneficial Antibacterial, Antioxidant and Anti-Inflammatory Properties for Wound Healing

Polymers, Год журнала: 2023, Номер 15(5), С. 1090 - 1090

Опубликована: Фев. 22, 2023

Bacterial infection and inflammation caused by excess oxidative stress are serious challenges in chronic wound healing. The aim of this work is to investigate a dressing based on natural- biowaste-derived biopolymers loaded with an herb extract that demonstrates antibacterial, antioxidant, anti-inflammatory activities without using additional synthetic drugs. Turmeric extract-loaded carboxymethyl cellulose/silk sericin dressings were produced esterification crosslinking citric acid followed freeze-drying achieve interconnected porous structure, sufficient mechanical properties, hydrogel formation situ contact aqueous solution. exhibited inhibitory effects the growth bacterial strains related controlled release turmeric extract. provided antioxidant activity as result radical scavenging effect DPPH, ABTS, FRAP radicals. To confirm their effects, inhibition nitric oxide production activated RAW 264.7 macrophages was investigated. findings suggested could be potential candidate for

Язык: Английский

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Electroactive Hydrogels with Photothermal/Photodynamic Effects for Effective Wound Healing Assisted by Polydopamine-Modified Graphene Oxide

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(36), С. 42329 - 42340

Опубликована: Авг. 30, 2023

Antibacterial hydrogel wound dressings have attracted considerable attention in recent years. However, bacterial infections can occur at any point during the wound-healing process. There is a demand for hydrogels that possess on-demand antibacterial and excellent repair properties. Herein, we report near-infrared (NIR)-light-responsive indocyanine green (ICG)-loaded polydopamine (PDA)-mediated graphene oxide (PGO) amorphous calcium phosphate (CaP)-incorporated poly(vinyl alcohol) (PVA) using mussel-inspired approach. PGO was reduced by PDA, which endowed with electroactivity provided abundant sites loading ICG. Amorphous CaP formed situ PVA to enhance its mechanical properties biocompatibility. Taking advantage of high photothermal photodynamic efficiency ICG-PGO, ICG-PGO-CaP-PVA exhibited fascinating activity through NIR light irradiation. Moreover, thermally induced gel–sol conversion accelerated release Ca ions allowed adapt irregular wounds. Meanwhile, endows conductivity cell affinity, facilitate endogenous electrical signal transfer control behavior. In vitro vivo studies demonstrated strong tissue under This strategy offers novel way design healing.

Язык: Английский

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Emerging trends and challenges in polysaccharide derived materials for wound care applications: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132048 - 132048

Опубликована: Май 3, 2024

Язык: Английский

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