Polymers,
Год журнала:
2022,
Номер
14(23), С. 5293 - 5293
Опубликована: Дек. 3, 2022
This
case
study
describes
the
use
of
additive
manufacturing
technology
combining
a
biodegradable
polymer
material,
polycaprolactone
(PCL),
and
innovative
procedures
for
creating
superficial
wound
dressing,
scaffold
in
therapy
extensive
contaminated
skin
defects
caused
by
traumatic
injury.
Chronic
wounds
represent
clinical
problem
require
intensive
care.
The
application
temporary
scaffold-facilitated
bridging
edges
resulted
faster
tissue
regeneration
shorter
defect
closure
time,
compared
to
other
conservative
surgical
methods
used
chronic
wounds.
Although
this
procedure
has
proven
be
an
optimal
alternative
autologous
transplants,
further
studies
with
larger
number
patients
would
beneficial.
Composites Part B Engineering,
Год журнала:
2023,
Номер
258, С. 110701 - 110701
Опубликована: Март 26, 2023
Biomimetic
scaffolds
supporting
tissue
regeneration
are
complex
materials
with
multifunctional
characteristics.
The
unique
biocompatibility
and
biodegradability
of
biopolymers
make
them
excellent
candidates
for
engineering
regenerative
medicine.
Biopolymers,
which
have
a
wide
range
properties,
can
be
obtained
from
different
natural
sources.
Depending
on
the
target
tissue,
engineered
to
meet
series
specific
functions.
We
review
types
their
composites,
besides
interactions
cells
tissues.
Specific
cellular
mechanisms
in
also
considered
elucidate
effects
controlling
given
advantages
challenging
aspects.
Furthermore,
modifications
required
mimic
properties
neural,
cardiac,
bone,
skin
tissues
discussed.
Utilization
biopolymer-based
composites
requires
additional
improvements,
where
several
challenges
should
overcome.
This
work
is
mainly
focused
used
engineering,
providing
support
future
biocomposites
same
purpose.
Some
examples
provided,
general
guide
selection
secondary
component
(biopolymers
as
complements,
additives,
or
nano-scale
biomaterials)
develop
biocomposites.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(15)
Опубликована: Фев. 2, 2024
Abstract
The
primary
challenges
posed
by
oral
mucosal
diseases
are
their
high
incidence
and
the
difficulty
in
managing
symptoms.
Inspired
ability
of
bioelectricity
to
activate
cells,
accelerate
metabolism,
enhance
immunity,
a
conductive
polyacrylamide/sodium
alginate
crosslinked
hydrogel
composite
containing
reduced
graphene
oxide
(PAA‐SA@rGO)
is
developed.
This
possesses
antibacterial,
anti‐inflammatory,
antioxidant
properties,
serving
as
bridge
turn
“short
circuit”
injured
site
into
“completed
circuit,”
thereby
prompting
fibroblasts
proximity
wound
secrete
growth
factors
expedite
tissue
regeneration.
Simultaneously,
PAA‐SA@rGO
effectively
seals
wounds
form
barrier,
exhibits
antibacterial
anti‐inflammatory
prevents
foreign
bacterial
invasion.
As
electric
field
rebuilt
repaired
hydrogel,
5
×
mm
2
full‐thickness
buccal
mucosa
rats
can
be
expeditiously
mended
within
mere
7
days.
theoretical
calculations
indicate
that
aggregate
express
SOX2,
PITX1,
PITX2
at
site,
which
has
promoting
effect
on
rapid
healing.
Importantly,
this
fast
curative
only
needs
applied
for
first
three
days,
significantly
improves
patient
satisfaction
during
treatment.
Biomaterials Science,
Год журнала:
2023,
Номер
11(20), С. 6711 - 6747
Опубликована: Янв. 1, 2023
Multifunctional
hydrogels
play
a
pivotal
role
against
infections,
inflammation,
and
oxidative
stress,
especially
for
endodontics
periodontics
treatment.
ACS Nano,
Год журнала:
2024,
Номер
18(26), С. 16395 - 16412
Опубликована: Июнь 14, 2024
Oral
health
is
the
basis
of
human
health,
and
almost
everyone
has
been
affected
by
oral
diseases.
Among
them,
endodontic
disease
one
most
common
Limited
characteristics
biomaterials,
clinical
methods
for
treatment
still
face
large
challenges
in
terms
reliability
stability.
The
hydrogel
a
kind
good
biomaterial
with
an
adjustable
3D
network
structure,
excellent
mechanical
properties,
biocompatibility
widely
used
basic
research
disease.
This
Review
discusses
recent
advances
functional
hydrogels
dental
hard
tissue
treatment.
emphasis
on
working
principles
therapeutic
effects
treating
different
diseases
hydrogels.
Finally,
opportunities
applications
are
discussed
proposed.
Some
viewpoints
about
possible
development
direction
future
also
put
forward.
Through
systematic
analysis
conclusion
treatment,
this
may
provide
significant
guidance
inspiration
future.
Biomacromolecules,
Год журнала:
2023,
Номер
24(7), С. 3345 - 3356
Опубликована: Июнь 28, 2023
Oral
defects
lead
to
a
series
of
function
disorders,
severely
threatening
the
patients'
health.
Although
injectable
hydrogels
are
widely
studied
in
tissue
regeneration,
their
mechanical
performance
is
usually
stationary
after
implant,
without
further
self-adaption
toward
microenvironment.
Herein,
an
hydrogel
with
programmed
kinetics
instant
gelation
and
gradual
self-strengthening
along
outstanding
biodegradation
ability
developed.
The
fast
realized
through
rapid
Schiff
base
reaction
between
biodegradable
chitosan
aldehyde-modified
sodium
hyaluronate,
while
achieved
via
slow
redundant
amino
groups
on
epoxy-modified
hydroxyapatite.
resultant
also
possesses
multiple
functions
including
(1)
bio-adhesion,
(2)
self-healing,
(3)
bactericidal,
(4)
hemostasis,
(5)
X-ray
situ
imaging,
which
can
be
effectively
used
for
oral
jaw
repair.
We
believe
that
strategy
illustrated
here
will
provide
new
insights
into
dynamic
regulation
promote
application
regeneration.
Macromolecular Bioscience,
Год журнала:
2023,
Номер
24(3)
Опубликована: Окт. 17, 2023
Abstract
The
rapid
growth
in
the
portion
of
aging
population
has
led
to
a
consequent
increase
demand
for
biomedical
hydrogels,
together
with
an
assortment
challenges
that
need
be
overcome
this
field.
Smart
hydrogels
can
autonomously
sense
and
respond
physiological/pathological
changes
tissue
microenvironment
continuously
adapt
response
according
dynamic
spatiotemporal
shifts
conditions.
This
along
other
favorable
properties,
make
smart
excellent
materials
employing
toward
improving
precision
treatment
age‐related
diseases.
key
factor
during
hydrogel
design
is
on
accurately
identifying
characteristics
natural
tissues
faithfully
replicating
composition,
structure,
biological
functions
these
at
molecular
level.
Such
distinct
physiological
external
factors
such
as
temperature
biologically
active
molecules,
so
they
may
turn
actively
promptly
adjust
their
response,
by
regulating
own
effects,
thereby
promoting
damaged
repair.
review
summarizes
strategies
employed
creation
mechanisms,
well
applications
field
engineering;
concludes
briefly
discussing
relevant
future
prospects.
