Therapy of Extensive Chronic Skin Defects after a Traumatic Injury Due to Microbial Contamination Using a Surface Implant Made of a Biocompatible Polycaprolactone—A Pilot Case Study DOI Open Access
Alena Findrik Balogová, Martin Kožár, Radka Staroňová

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(23), P. 5293 - 5293

Published: Dec. 3, 2022

This case study describes the use of additive manufacturing technology combining a biodegradable polymer material, polycaprolactone (PCL), and innovative procedures for creating superficial wound dressing, scaffold in therapy extensive contaminated skin defects caused by traumatic injury. Chronic wounds represent clinical problem require intensive care. The application temporary scaffold-facilitated bridging edges resulted faster tissue regeneration shorter defect closure time, compared to other conservative surgical methods used chronic wounds. Although this procedure has proven be an optimal alternative autologous transplants, further studies with larger number patients would beneficial.

Language: Английский

Biopolymer-based composites for tissue engineering applications: A basis for future opportunities DOI Creative Commons

Payam Zarrintaj,

Farzad Seidi, Mohamadreza Youssefi Azarfam

et al.

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 258, P. 110701 - 110701

Published: March 26, 2023

Biomimetic scaffolds supporting tissue regeneration are complex materials with multifunctional characteristics. The unique biocompatibility and biodegradability of biopolymers make them excellent candidates for engineering regenerative medicine. Biopolymers, which have a wide range properties, can be obtained from different natural sources. Depending on the target tissue, engineered to meet series specific functions. We review types their composites, besides interactions cells tissues. Specific cellular mechanisms in also considered elucidate effects controlling given advantages challenging aspects. Furthermore, modifications required mimic properties neural, cardiac, bone, skin tissues discussed. Utilization biopolymer-based composites requires additional improvements, where several challenges should overcome. This work is mainly focused used engineering, providing support future biocomposites same purpose. Some examples provided, general guide selection secondary component (biopolymers as complements, additives, or nano-scale biomaterials) develop biocomposites.

Language: Английский

Citations

124

Probiotic-loaded calcium alginate/fucoidan hydrogels for promoting oral ulcer healing DOI

Xue Dou,

Guotai Li, Shuang Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 244, P. 125273 - 125273

Published: June 9, 2023

Language: Английский

Citations

29

Dental delivery systems of antimicrobial drugs using chitosan, alginate, dextran, cellulose and other polysaccharides: A review DOI
Mousumi Paul, Siddhartha Das Pramanik, Rudra Narayan Sahoo

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 247, P. 125808 - 125808

Published: July 17, 2023

Language: Английский

Citations

24

From Short Circuit to Completed Circuit: Conductive Hydrogel Facilitating Oral Wound Healing DOI
Qiangqiang Zhou, Hanqing Dai, Yukun Yan

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(15)

Published: Feb. 2, 2024

Abstract The primary challenges posed by oral mucosal diseases are their high incidence and the difficulty in managing symptoms. Inspired ability of bioelectricity to activate cells, accelerate metabolism, enhance immunity, a conductive polyacrylamide/sodium alginate crosslinked hydrogel composite containing reduced graphene oxide (PAA‐SA@rGO) is developed. This possesses antibacterial, anti‐inflammatory, antioxidant properties, serving as bridge turn “short circuit” injured site into “completed circuit,” thereby prompting fibroblasts proximity wound secrete growth factors expedite tissue regeneration. Simultaneously, PAA‐SA@rGO effectively seals wounds form barrier, exhibits antibacterial anti‐inflammatory prevents foreign bacterial invasion. As electric field rebuilt repaired hydrogel, 5 × mm 2 full‐thickness buccal mucosa rats can be expeditiously mended within mere 7 days. theoretical calculations indicate that aggregate express SOX2, PITX1, PITX2 at site, which has promoting effect on rapid healing. Importantly, this fast curative only needs applied for first three days, significantly improves patient satisfaction during treatment.

Language: Английский

Citations

14

New sustainable antimicrobial chitosan hydrogels based on sulfonamides and its nanocomposites: Fabrication and characterization DOI
Nadia G. Kandile,

Rana A. Elzamly,

Mansoura I. Mohamed

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 239, P. 124280 - 124280

Published: April 3, 2023

Language: Английский

Citations

19

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics DOI Creative Commons
Deniz Atila, Vignesh Kumaravel

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(20), P. 6711 - 6747

Published: Jan. 1, 2023

Multifunctional hydrogels play a pivotal role against infections, inflammation, and oxidative stress, especially for endodontics periodontics treatment.

Language: Английский

Citations

19

Polysaccharide-Based Injectable Hydrogels with Fast Gelation and Self-Strengthening Mechanical Kinetics for Oral Tissue Regeneration DOI

Yucong Gu,

Yuting Yang,

Jingfeng Yuan

et al.

Biomacromolecules, Journal Year: 2023, Volume and Issue: 24(7), P. 3345 - 3356

Published: June 28, 2023

Oral defects lead to a series of function disorders, severely threatening the patients' health. Although injectable hydrogels are widely studied in tissue regeneration, their mechanical performance is usually stationary after implant, without further self-adaption toward microenvironment. Herein, an hydrogel with programmed kinetics instant gelation and gradual self-strengthening along outstanding biodegradation ability developed. The fast realized through rapid Schiff base reaction between biodegradable chitosan aldehyde-modified sodium hyaluronate, while achieved via slow redundant amino groups on epoxy-modified hydroxyapatite. resultant also possesses multiple functions including (1) bio-adhesion, (2) self-healing, (3) bactericidal, (4) hemostasis, (5) X-ray situ imaging, which can be effectively used for oral jaw repair. We believe that strategy illustrated here will provide new insights into dynamic regulation promote application regeneration.

Language: Английский

Citations

16

Recent Advances in Functional Hydrogels for Treating Dental Hard Tissue and Endodontic Diseases DOI

Huixu Li,

Ding Zhang, Pingping Bao

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16395 - 16412

Published: June 14, 2024

Oral health is the basis of human health, and almost everyone has been affected by oral diseases. Among them, endodontic disease one most common Limited characteristics biomaterials, clinical methods for treatment still face large challenges in terms reliability stability. The hydrogel a kind good biomaterial with an adjustable 3D network structure, excellent mechanical properties, biocompatibility widely used basic research disease. This Review discusses recent advances functional hydrogels dental hard tissue treatment. emphasis on working principles therapeutic effects treating different diseases hydrogels. Finally, opportunities applications are discussed proposed. Some viewpoints about possible development direction future also put forward. Through systematic analysis conclusion treatment, this may provide significant guidance inspiration future.

Language: Английский

Citations

5

Sustainable Polysaccharide Hydrogels Based on Dynamic Schiff Base Linkages as Versatile Building Blocks for Fabricating Advanced Functional Materials DOI
Shashank Shekhar, Vijay Chaudhary, Bhasha Sharma

et al.

Journal of Polymers and the Environment, Journal Year: 2022, Volume and Issue: 31(4), P. 1257 - 1278

Published: Nov. 30, 2022

Language: Английский

Citations

17

Smart injectable hydrogels for periodontal regeneration: Recent Advancements in Biomaterials and Biofabrication Strategies DOI Creative Commons
Bohan Yin, Jagan Mohan Dodda, Siu Hong Dexter Wong

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101855 - 101855

Published: May 1, 2025

Language: Английский

Citations

0