Composites Part B Engineering,
Год журнала:
2024,
Номер
275, С. 111280 - 111280
Опубликована: Фев. 5, 2024
Intervertebral
disc
degeneration
(IVDD)
plays
a
pivotal
etiological
role
in
low
back
pain,
which
is
global
cause
of
disability.
Although
the
underlying
pathological
processes
and
mechanisms
IVDD
are
complex,
oxidative
stress
extracellular
matrix
degradation
recognized
as
crucial
determinants
degeneration.
The
delicate
equilibrium
between
reactive
oxygen
species
antioxidants
holds
profound
significance
maintaining
normal
cellular
functions,
while
maintains
intervertebral
stability.
This
study
developed
bioadhesive
with
mechanical
properties
similar
to
those
nucleus
pulposus,
an
injectable
hydrogel.
Unlike
other
antioxidative
drug
carrier
materials,
this
hydrogel
achieved
removal
through
material
loaded
transforming
growth
factor-beta
3
gradually
released
regulate
matrix.
Cellular
experiments
demonstrated
ability
scavenge
radicals,
stimulate
pulposus
cell
migration,
collagen
secretion.
Moreover,
radiographic
histological
analyses
needle-induced
rat-tail
model
confirmed
potential
restore
height,
maintain
hydration,
preserve
tissue
structure,
promote
These
findings
have
promising
implications
for
efficacy
hydrogels
ameliorating
IVDD.
Gels,
Год журнала:
2024,
Номер
10(4), С. 241 - 241
Опубликована: Апрель 1, 2024
This
manuscript
explores
self-healing
hydrogels
as
innovative
solutions
for
diverse
wound
management
challenges.
Addressing
antibiotic
resistance
and
tailored
care,
these
exhibit
promising
outcomes,
including
accelerated
closure
tissue
regeneration.
Advancements
in
multifunctional
with
controlled
drug
release,
antimicrobial
properties,
real-time
assessment
capabilities
signal
a
significant
leap
toward
patient-centered
treatments.
However,
challenges
such
scalability,
long-term
safety
evaluation,
variability
clinical
outcomes
persist.
Future
directions
emphasize
personalized
medicine,
manufacturing
innovation,
rigorous
evaluation
through
trials,
interdisciplinary
collaboration.
features
the
ongoing
pursuit
of
effective,
adaptable,
comprehensive
care
to
transform
medical
treatments
improve
patient
outcomes.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 25, 2024
Abstract
Traditional
hydrogels
often
face
issues
like
dehydration,
excessive
swelling,
and
poor
adhesion,
limiting
their
practical
applications.
This
study
presents
a
facile
universal
method
to
create
elastomer‐encapsulated
with
improved
water
retention,
non‐swelling,
enhanced
adhesion.
n‐Butyl
acrylate
(BA)
2,2,3,4,4,4‐hexafluorobutyl
methacrylate
(HFBMA)
are
utilized
as
the
“soft”
“hard”
monomers,
respectively,
in
situ
construct
elastomer
coatings
on
hydrogel
surface
through
surface‐confined
copolymerization.
The
resulting
transparent,
hydrophobic,
adhesive
coating
is
tightly
bound
surface,
conferring
upon
it
robust
defense
against
dehydration
swelling
various
media,
strong
adhesion
diverse
substrates
both
aerial
submerged
conditions.
Furthermore,
this
encapsulation
strategy
also
augments
mechanical
attributes
of
bulk
hydrogel,
including
its
tensile
properties
puncture
resistance,
applicable
wide
array
types
configurations.
Additionally,
applied
conductive
results
flexible
sensors
high
sensitivity,
reversible
resistance
change,
exceptional
sensing
stability,
significantly
durability
air
underwater
environments.
These
suggest
potential
applications
harsh
environments,
such
acoustic
detection
sonar
scanning
camouflage
for
submarines.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Diabetic
wounds
are
refractory
and
recurrent
diseases
that
necessitate
the
development
of
multifunctional
dressings.
Inspired
by
structure
function
skin,
we
herein
delicately
design
a
novel
swollen
hydrophobic
hydrogel
(QL@MAB)
composed
methyl
acrylate
(MA)
(3-acrylamidophenyl)boronic
acid
(AAPBA)
network
co-loaded
with
antioxidant
quercetin
(Q)
antibiotic
levofloxacin
(L)
for
efficient
diabetic
wound
therapy.
The
MA
segments
undergo
phase
separation
to
form
dense
"epidermis",
ensuring
prolonged
drug
diffusion,
long-term
water
retention,
high
content.
Meanwhile,
AAPBA
generate
glucose-labile
"sweat
pores"
via
borate
ester
bonds
polyphenol
Q.
Upon
encountering
hyperglycemic
microenvironment,
dilated
due
cleavage
exposure
diffusion
channel,
facilitating
release
accelerated
healing.
In
infected
rats,
QL@MAB
achieves
rapid
debridement
re-epithelization
while
promoting
angiogenesis,
hair
follicle
regeneration,
extracellular
matrix
remodeling.
Taken
together,
this
study
not
only
represents
multipronged
dressing
effective
interventions
but
also
contributes
rational
smart
hydrogels
tailored
biomedical
applications.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(23), С. 16714 - 16714
Опубликована: Ноя. 24, 2023
Numerous
innovative
advancements
in
dressing
technology
for
wound
healing
have
emerged.
Among
the
various
types
of
dressings
available,
hydrogel
dressings,
structured
with
a
three-dimensional
network
and
composed
predominantly
hydrophilic
components,
are
widely
used
care
due
to
their
remarkable
capacity
absorb
abundant
exudate,
maintain
moisture
environment,
provide
soothing
cooling
effects,
mimic
extracellular
matrix.
Composite
one
evolved
address
limitations
traditional
by
incorporating
additional
including
particles,
fibers,
fabrics,
or
foams,
within
hydrogels,
effectively
promoting
treatment
healing.
The
added
elements
enhance
features
add
specific
functionalities
such
as
sensitivity
external
factors,
adhesiveness,
mechanical
strength,
control
over
release
therapeutic
agents,
antioxidant
antimicrobial
properties,
tissue
regeneration
behavior.
They
can
be
categorized
natural
synthetic
based
on
origin
main
components
network.
This
review
focuses
recent
research
developing
polysaccharide-based
composite
dressings.
It
explores
preparation
composition,
reinforcement
materials
integrated
into
agents.
Furthermore,
it
discusses
wounds
where
applied.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(9)
Опубликована: Ноя. 20, 2023
Abstract
Smart
wound
dressings
capable
of
detecting,
monitoring,
and
regulating
complicated
dynamic
healing
processes
hold
tremendous
potential
in
tissue
reconstruction.
Micro/nanofiber‐based
materials
are
regarded
as
one
the
most
promising
candidates
to
develop
smart
owing
their
remarkable
features
including
architectural
mimicry
extracellular
matrix,
tunability
structural
assembly,
diversity
functionality.
Herein,
latest
progress
micro/nanoscale
fiber‐based
terms
composition
engineering,
design,
applications
management
is
comprehensively
reviewed.
This
work
begins
with
advances
fibers
stimuli‐responsive
fibers,
shape
memory
conductive
fibers.
Then,
design
from
conventional
2D
fibrous
membrane
emerging
3D
sponge/hydrogel
thoroughly
discussed.
Furthermore,
micro/nanofibrous
drug
delivery,
biomechanical
stimulation,
electrical
monitoring
highlighted.
Finally,
article
offers
perspectives
on
existing
challenges
future
directions
for
management.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 4, 2024
Abstract
Chronic
wounds
are
inherently
vulnerable
to
external
mechanical
contact
owing
their
impaired
physiological
states.
Accidental
touching
may
lead
secondary
damage
delicate
wound
tissues,
including
deterioration
of
tissue
and
inflammation,
thereby
prolonging
the
healing
process.
In
addition,
patients
encounter
nociceptive
sensations,
indicative
physical
discomfort
potential
distress.
However,
traditional
dressings
for
chronic
fail
convey
adequate
perceptual
information
prevent
trauma.
An
electrostatic‐induction‐enabled
anti‐touching
hydrogel
dressing
(EAHD)
is
proposed,
which
promotes
reduces
touching‐induced
injuries.
The
EAHD
combines
a
proximity
sensor
pro‐healing
hydrogel.
can
detect
approaching
objects,
enabling
remote
perception.
More
importantly,
wireless
alarm
system
integrated
warn
against
detected
hazards
such
as
unintentional
touching.
Meanwhile,
significantly
accelerates
in
preclinical
diabetic
mice,
≈38%
faster
than
that
control
group.
This
study
proposes
novel
strategy
multifunctional
prevents
accidental
wound.
