International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11092 - 11092
Опубликована: Окт. 15, 2024
Mineralization
is
a
key
biological
process
that
required
for
the
development
and
repair
of
tissues
such
as
teeth,
bone
cartilage.
Exosomes
(Exo)
are
subset
extracellular
vesicles
(~50–150
nm)
secreted
by
cells
contain
genetic
material,
proteins,
lipids,
nucleic
acids,
other
substances
have
been
extensively
researched
oral
tissue
regeneration.
However,
Exo-free
biomaterials
or
exosome
treatments
exhibit
poor
bioavailability
lack
controlled
release
mechanisms
at
target
site
during
By
encapsulating
Exos
into
like
hydrogels,
these
disadvantages
can
be
mitigated.
Several
engineering
approaches,
those
wound
healing
processes
in
diabetes
mellitus,
treatment
osteoarthritis
(OA)
cartilage
degeneration,
intervertebral
disc
cardiovascular
diseases,
etc.,
exploited
to
deliver
exosomes
containing
variety
therapeutic
diagnostic
cargos
tissues.
Despite
significant
efficacy
Exo-laden
their
use
mineralized
tissues,
tissue,
very
sparse.
This
review
aims
explore
summarize
literature
related
potential
hydrogel-encapsulated
provides
insight
practical
procedures
future
clinical
techniques.
Materials Today Bio,
Год журнала:
2024,
Номер
25, С. 101014 - 101014
Опубликована: Фев. 29, 2024
Traditional
hydrogel
design
and
optimization
methods
usually
rely
on
repeated
experiments,
which
is
time-consuming
expensive,
resulting
in
a
slow-moving
of
advanced
development.
With
the
rapid
development
artificial
intelligence
(AI)
technology
increasing
material
data,
AI-energized
hydrogels
for
biomedical
applications
has
emerged
as
revolutionary
breakthrough
materials
science.
This
review
begins
by
outlining
history
AI
potential
advantages
using
hydrogels,
such
prediction
properties,
multi-attribute
optimization,
high-throughput
screening,
automated
discovery,
optimizing
experimental
design,
etc.
Then,
we
focus
various
supported
biomedicine,
including
drug
delivery,
bio-inks
manufacturing,
tissue
repair,
biosensors,
so
to
provide
clear
comprehensive
understanding
researchers
this
field.
Finally,
discuss
future
directions
prospects,
new
perspective
research
novel
applications.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(27)
Опубликована: Июнь 2, 2024
Abstract
Hydrogels
are
dynamically
evolving
3D
networks
composed
of
hydrophilic
polymer
scaffolds
with
significant
applications
in
the
healthcare
and
environmental
sectors.
Notably,
protein‐based
hydrogels
mimic
extracellular
matrix,
promoting
cell
adhesion.
Further
enhancing
proliferation
within
these
matrix‐metalloproteinase‐triggered
amino
acid
motifs.
Integration
cell‐friendly
modules
like
peptides
proteins
expands
hydrogel
functionality.
These
exceptional
properties
position
for
diverse
applications,
including
biomedicine,
biosensors,
remediation,
food
industry.
Despite
progress,
there
is
ongoing
research
to
optimize
biomedical
further.
Engineering
novel
favorable
characteristics
crucial
regulating
tissue
architecture
facilitating
ecological
remediation.
This
review
explores
synthesis,
physicochemical
properties,
biological
implications
various
types
their
extensive
biomedicine
It
elaborates
on
potential
bridging
gap
between
advancements
sector
solutions
issues.
ACS Omega,
Год журнала:
2024,
Номер
9(6), С. 6184 - 6218
Опубликована: Янв. 31, 2024
Extracellular
vesicles
have
emerged
as
promising
tools
in
regenerative
medicine
due
to
their
inherent
ability
facilitate
intercellular
communication
and
modulate
cellular
functions.
These
nanosized
transport
bioactive
molecules,
such
proteins,
lipids,
nucleic
acids,
which
can
affect
the
behavior
of
recipient
cells
promote
tissue
regeneration.
However,
therapeutic
application
these
is
frequently
constrained
by
rapid
clearance
from
body
inability
maintain
a
sustained
presence
at
injury
site.
In
order
overcome
obstacles,
hydrogels
been
used
extracellular
vesicle
delivery
vehicles,
providing
localized
controlled
release
system
that
improves
efficacy.
This
Review
will
examine
role
vesicle-loaded
regeneration,
discussing
potential
applications,
current
challenges,
future
directions.
We
investigate
origins,
composition,
characterization
techniques
vesicles,
focusing
on
recent
advances
exosome
profiling
machine
learning
this
field.
addition,
we
properties
make
them
ideal
carriers.
Recent
studies
utilizing
combination
for
regeneration
be
highlighted,
comprehensive
overview
research
landscape
Composites Part B Engineering,
Год журнала:
2024,
Номер
272, С. 111221 - 111221
Опубликована: Янв. 15, 2024
Bone
marrow
mesenchymal
stem
cells
(BMSCs)-based
engineered
cartilage
usually
faces
the
significant
challenge
of
endochondral
ossification
tendency
in
an
ectopic
environment
because
inevitable
vascular
infiltration
during
chondrogenic
differentiation
and
developmental
stages.
Additionally,
current
scaffold-free
BMSC
regeneration
requires
a
long
vitro
preinduction
time
for
before
vivo
transplantation,
which
limits
its
application
multiple
defect
repair.
Therefore,
ideal
cell-based
needs
to
meet
time-dependent
requirements
both
early
late
anti-angiogenic
microenvironments
vivo.
Here,
we
developed
cartilage-specific
matrix
hydrogel
(CMH)
with
dual
microparticle-based
programmed
delivery
system
(dM-PDs)
dynamically
regulate
without
preinduction.
In
this
study,
CMH
scaffolds
offer
three-dimensional
microenvironment
tissue
regeneration,
while
dM-PDs
has
induction
function
promote
exerts
effect
stabilize
cartilaginous
phenotype.
Stem
was
successfully
achieved
by
sequentially
dynamic
regulation
dM-PDs,
TGFβ3-loaded
microparticles
effectively
activated
early-stage
TGFβ/Smad
signaling
pathway
levatinib-loaded
regulated
late-stage
VEGF/TIMP
pathway.
This
study
demonstrates
universal
technique
clinical
defects
