Current Perspectives of Mitochondria in Sepsis-Induced Cardiomyopathy

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4710 - 4710

Опубликована: Апрель 26, 2024

Sepsis-induced cardiomyopathy (SICM) is one of the leading indicators for poor prognosis associated with sepsis. Despite its reversibility, varies widely among patients. Mitochondria play a key role in cellular energy production by generating adenosine triphosphate (ATP), which vital myocardial metabolism. Over recent years, mounting evidence suggests that severe sepsis not only triggers mitochondrial structural abnormalities such as apoptosis, incomplete autophagy, and mitophagy cardiomyocytes but also compromises their function, to ATP depletion. This metabolic disruption recognized significant contributor SICM, yet effective treatment options remain elusive. Sepsis cannot be effectively treated inotropic drugs failing myocardium due excessive inflammatory factors blunt β-adrenergic receptors. review will share knowledge on cell death molecular mechanisms, focusing mitochondria an important regulator discuss potential developing therapies sepsis-induced injury.

Язык: Английский

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FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1870(7), С. 167307 - 167307

Опубликована: Июнь 17, 2024

Язык: Английский

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Vaccarin alleviates septic cardiomyopathy by potentiating NLRP3 palmitoylation and inactivation

Phytomedicine, Год журнала: 2024, Номер 131, С. 155771 - 155771

Опубликована: Май 31, 2024

Язык: Английский

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Ablation of Mitophagy Receptor FUNDC1 Accentuates Septic Cardiomyopathy through ACSL4-Dependent Regulation of Ferroptosis and Mitochondrial Integrity

Free Radical Biology and Medicine, Год журнала: 2024, Номер 225, С. 75 - 86

Опубликована: Сен. 24, 2024

Язык: Английский

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Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis

Acta Pharmacologica Sinica, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Язык: Английский

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ZC3H13 may participate in the ferroptosis process of sepsis-induced cardiomyopathy by regulating the expression of Pnn and Rbm25

Gene, Год журнала: 2024, Номер unknown, С. 148944 - 148944

Опубликована: Сен. 1, 2024

Язык: Английский

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KLF2 Inhibits Ferroptosis and Improves Mitochondrial Dysfunction in Chondrocyte Through SIRT1/GPX4 Signaling to Improve Osteoarthritis

Drug Development Research, Год журнала: 2024, Номер 85(7)

Опубликована: Ноя. 1, 2024

Osteoarthritis (OA), a disease of articular joints, is the leading cause disability in elderly. Repressing ferroptosis and improving mitochondrial function can delay progression OA. Kruppel-like factor 2 (KLF2) exerts protective effect on However, whether KLF2 affects during OA remains unknown. The vivo vitro models were constructed this work. structural damage knee joint mice was evaluated through Micro-CT scanning. H&E, SOFG, TB, TUNEL staining applied for pathological examination cartilage tissues. ELISA employed to examine contents inflammatory factors. Additionally, iron deposition tissues measured by Prussian blue staining, levels proteins related assessed immunoblotting. Besides, morphology estimated using transmission electron microscope JC-1 staining. In interleukin (IL)-1β-treated C28/I2 cells, factors, intracellular ROS, lipid Fe

Язык: Английский

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COX-2 optimizes cardiac mitochondrial biogenesis and exerts a cardioprotective effect during sepsis

Cytokine, Год журнала: 2024, Номер 182, С. 156733 - 156733

Опубликована: Авг. 10, 2024

Язык: Английский

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