International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(15), С. 12421 - 12421
Опубликована: Авг. 4, 2023
Microplastics
(MPs)
are
recognized
as
environmental
pollutants
with
potential
implications
for
human
health.
Considering
the
rapid
increase
in
obesity
rates
despite
stable
caloric
intake,
there
is
a
growing
concern
about
link
between
and
exposure
to
pollutants,
including
MPs.
In
this
study,
we
conducted
comprehensive
investigation
utilizing
silico,
vitro,
vivo
approaches
explore
brain
distribution
physiological
effects
of
Molecular
docking
simulations
were
performed
assess
binding
affinity
three
plastic
polymers
(ethylene,
propylene,
styrene)
immune
cells
(macrophages,
CD4+,
CD8+
lymphocytes).
The
results
revealed
that
styrene
exhibited
highest
macrophages.
Furthermore,
vitro
experiments
employing
fluorescence-labeled
PS-MPs
(fPS-MPs)
1
μm
at
various
concentrations
demonstrated
dose-dependent
fPS-MPs
BV2
murine
microglial
cells.
Subsequent
oral
administration
high-fat
diet-induced
obese
mice
led
co-existence
blood,
exacerbating
impaired
glucose
metabolism
insulin
resistance
promoting
systemic
inflammation.
Additionally,
detected
throughout
brain,
increased
activation
microglia
hypothalamus.
These
findings
suggest
significantly
contribute
exacerbation
inflammation
by
activating
peripheral
central
inflammatory
Eco-Environment & Health,
Год журнала:
2023,
Номер
2(4), С. 195 - 207
Опубликована: Авг. 21, 2023
Micro-
and
nano-plastics
(MNPs)
pollution
has
become
a
pressing
global
environmental
issue,
with
growing
concerns
regarding
its
impact
on
human
health.
However,
evidence
the
effects
of
MNPs
health
remains
limited.
This
paper
reviews
three
routes
exposure
to
MNPs,
which
include
ingestion,
inhalation,
dermal
contact.
It
further
discusses
potential
translocation
in
lungs,
intestines,
skin,
analyses
homeostasis
organ
systems,
provides
an
outlook
future
research
priorities
for
There
is
that
are
present
tissues
or
fluids.
Lab
studies,
including
Advanced Materials Interfaces,
Год журнала:
2022,
Номер
10(2)
Опубликована: Ноя. 30, 2022
Abstract
Hydrogels
have
been
employed
for
water
purification
applications,
but
their
performance
and
strength
are
unsatisfactory
widespread
adoption.
Recently,
hydrogel
nanocomposites
proposed
to
resolve
the
inherent
challenges
faced
by
hydrogels
treatment.
This
review
comprehensively
analyzes
treatment
using
adsorbent
photocatalysis
techniques.
The
structure,
classification,
tunable
synthesis
methods
of
explained.
Further,
how
can
be
incorporated
with
functional
nanoparticles
(NPs)
used
as
templates/precursors
developing
advanced
3D
architectures,
including
formation
nanocomposite
beads
printing
objects
discussed.
Finally,
structure‐property
relationships
critically
reviewed
considering
introductory
gelation
chemistry,
such
swelling
characteristics,
mechanical
properties,
stimuli‐responsiveness,
ionic/electronic
conduction.
extensive
cross‐linking
polymer
chains
NPs
offers
high
mass/charge
transport,
surface
areas,
enhanced
polymer‐water
interactions
achieve
high‐performing
adsorbents
photocatalysts.
Several
motivating
examples
emerging
NP‐containing
use
in
Such
efforts
validated
excellent
technological
potential
held
applications.
future
directions
sustainable
proposed.
International Journal of Environmental Research and Public Health,
Год журнала:
2023,
Номер
20(14), С. 6434 - 6434
Опубликована: Июль 23, 2023
Plastic
materials
that
are
less
than
5
mm
in
size
defined
as
Microplastics
(MPs).
MPs
intentionally
produced
called
primary
MPs;
however,
the
most
abundant
type
environment
consists
of
remainder
created
by
fragmentation
large
plastic
debris
through
physical,
chemical,
and
oxidative
processes,
which
secondary
MPs.
Due
to
their
abundance
environment,
poor
degradability,
toxicological
properties,
negative
impact
on
aquatic
terrestrial
organisms,
including
humans,
MP
pollution
has
become
a
global
environmental
issue.
Combatting
requires
both
remediation
preventive
measures.
Although
is
must,
considering
where
technology
stands
today,
it
may
take
long
time
make
happen.
Prevention,
other
hand,
can
be
should
done
now.
However,
effectiveness
measures
depends
heavily
how
well
escape
routes
researched
understood.
In
this
research,
we
argue
such
(rather,
loopholes)
exist
not
only
due
mismanaged
waste,
but
also
cracks
current
waste
management
systems.
One
known
loophole
facilitated
wastewater
treatment
plants
(WWTP).
The
inability
existing
WWTP
retain
finer
MPs,
finally
released
water
bodies
together
with
treated
wastewater,
along
return
captured
larger
back
landfills
release
into
land
applications,
few
examples.
Organic
composting
upcycling
incineration
ash
provide
pathways.
addition,
important
understand
plastics
circulation
(active
use
idling)
responsible
for
producing
regular
wear
tear.
Closing
these
loopholes
best
attempted
policy
interventions.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Март 6, 2024
Abstract
Background
Nanoplastics
(NPs)
are
now
a
new
class
of
pollutants
widely
present
in
the
soil,
atmosphere,
freshwater
and
marine
environments.
can
rapidly
penetrate
cell
membranes
accumulate
human
tissues
organs,
thus
posing
potential
threat
to
health.
The
heart
is
main
power
source
body.
But
up
now,
toxicological
effects
long-term
exposure
nanoplastics
on
has
not
been
revealed
yet.
Results
We
evaluated
long
term
cardiac
cell/tissue
vitro
vivo
model.
Furthermore,
we
explored
molecular
mechanism
by
which
causes
myocardial
senescence.
Immunohistochemistry,
indirect
immunofluorescence
ELISA
were
performed
detect
aging.
found
that
able
induce
significant
aging
through
series
biochemical
assays
vivo.
In
vitro,
investigated,
internalize
into
cardiomyocytes
time
dose-dependant
manner.
Further
analysis
showed
induces
senescence
detecting
marker
molecules.
Molecular
research
shows
may
cause
mitochondrial
destabilization
inducing
oxidative
stress,
leads
leakage
mtDNA
from
mitochondria
cytoplasm,
then
cytoplasm-localized
mt-DNA
activates
cGAS-STING
signaling
pathway
promotes
inflammation
response,
ultimately
Conclusions
this
work,
premature
heart.
Current
also
reveals
cardiomyocyte
This
study
laid
foundation
for
further
studying
harm
Graphical
abstract
