Polystyrene Microplastics Exacerbate Systemic Inflammation in High-Fat Diet-Induced Obesity DOI Open Access

Aden Geonhee Lee,

Sora Kang, Hye Ji Yoon

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12421 - 12421

Published: Aug. 4, 2023

Microplastics (MPs) are recognized as environmental pollutants with potential implications for human health. Considering the rapid increase in obesity rates despite stable caloric intake, there is a growing concern about link between and exposure to pollutants, including MPs. In this study, we conducted comprehensive investigation utilizing silico, vitro, vivo approaches explore brain distribution physiological effects of Molecular docking simulations were performed assess binding affinity three plastic polymers (ethylene, propylene, styrene) immune cells (macrophages, CD4+, CD8+ lymphocytes). The results revealed that styrene exhibited highest macrophages. Furthermore, vitro experiments employing fluorescence-labeled PS-MPs (fPS-MPs) 1 μm at various concentrations demonstrated dose-dependent fPS-MPs BV2 murine microglial cells. Subsequent oral administration high-fat diet-induced obese mice led co-existence blood, exacerbating impaired glucose metabolism insulin resistance promoting systemic inflammation. Additionally, detected throughout brain, increased activation microglia hypothalamus. These findings suggest significantly contribute exacerbation inflammation by activating peripheral central inflammatory

Language: Английский

From natural environment to animal tissues: A review of microplastics(nanoplastics) translocation and hazards studies DOI
Xusheng Dong, Xinbei Liu, Qiuling Hou

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 855, P. 158686 - 158686

Published: Sept. 10, 2022

Language: Английский

Citations

155

Fate of microplastics in the drinking water production DOI
Patrick S. Bäuerlein, C.H.M. Hofman-Caris, Eelco N. Pieke

et al.

Water Research, Journal Year: 2022, Volume and Issue: 221, P. 118790 - 118790

Published: June 24, 2022

Language: Английский

Citations

110

A systematic review of the impacts of exposure to micro- and nano-plastics on human tissue accumulation and health DOI Creative Commons
Yudong Feng,

Chen Tu,

Ruijie Li

et al.

Eco-Environment & Health, Journal Year: 2023, Volume and Issue: 2(4), P. 195 - 207

Published: Aug. 21, 2023

Micro- and nano-plastics (MNPs) pollution has become a pressing global environmental issue, with growing concerns regarding its impact on human health. However, evidence the effects of MNPs health remains limited. This paper reviews three routes exposure to MNPs, which include ingestion, inhalation, dermal contact. It further discusses potential translocation in lungs, intestines, skin, analyses homeostasis organ systems, provides an outlook future research priorities for There is that are present tissues or fluids. Lab studies, including

Language: Английский

Citations

81

Hydrogel Nanocomposite Adsorbents and Photocatalysts for Sustainable Water Purification DOI Creative Commons
Neeraj Kumar, Rashi Gusain, Sadanand Pandey

et al.

Advanced Materials Interfaces, Journal Year: 2022, Volume and Issue: 10(2)

Published: Nov. 30, 2022

Abstract Hydrogels have been employed for water purification applications, but their performance and strength are unsatisfactory widespread adoption. Recently, hydrogel nanocomposites proposed to resolve the inherent challenges faced by hydrogels treatment. This review comprehensively analyzes treatment using adsorbent photocatalysis techniques. The structure, classification, tunable synthesis methods of explained. Further, how can be incorporated with functional nanoparticles (NPs) used as templates/precursors developing advanced 3D architectures, including formation nanocomposite beads printing objects discussed. Finally, structure‐property relationships critically reviewed considering introductory gelation chemistry, such swelling characteristics, mechanical properties, stimuli‐responsiveness, ionic/electronic conduction. extensive cross‐linking polymer chains NPs offers high mass/charge transport, surface areas, enhanced polymer‐water interactions achieve high‐performing adsorbents photocatalysts. Several motivating examples emerging NP‐containing use in Such efforts validated excellent technological potential held applications. future directions sustainable proposed.

Language: Английский

Citations

80

Occurrence of microplastics in commercially sold bottled water DOI
Huan Li, Long Zhu,

Mindong Ma

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 867, P. 161553 - 161553

Published: Jan. 11, 2023

Language: Английский

Citations

80

Microplastic Pollution Prevention: The Need for Robust Policy Interventions to Close the Loopholes in Current Waste Management Practices DOI Open Access
Hiroshan Hettiarachchi, Jay N. Meegoda

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(14), P. 6434 - 6434

Published: July 23, 2023

Plastic materials that are less than 5 mm in size defined as Microplastics (MPs). MPs intentionally produced called primary MPs; however, the most abundant type environment consists of remainder created by fragmentation large plastic debris through physical, chemical, and oxidative processes, which secondary MPs. Due to their abundance environment, poor degradability, toxicological properties, negative impact on aquatic terrestrial organisms, including humans, MP pollution has become a global environmental issue. Combatting requires both remediation preventive measures. Although is must, considering where technology stands today, it may take long time make happen. Prevention, other hand, can be should done now. However, effectiveness measures depends heavily how well escape routes researched understood. In this research, we argue such (rather, loopholes) exist not only due mismanaged waste, but also cracks current waste management systems. One known loophole facilitated wastewater treatment plants (WWTP). The inability existing WWTP retain finer MPs, finally released water bodies together with treated wastewater, along return captured larger back landfills release into land applications, few examples. Organic composting upcycling incineration ash provide pathways. addition, important understand plastics circulation (active use idling) responsible for producing regular wear tear. Closing these loopholes best attempted policy interventions.

Language: Английский

Citations

45

Occurrence, transport, and toxicity of microplastics in tropical food chains: perspectives view and way forward DOI
Navish Kataria, Sangita Yadav, Vinod Kumar Garg

et al.

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 46(3)

Published: Feb. 23, 2024

Language: Английский

Citations

23

Nanoplastics causes heart aging/myocardial cell senescence through the Ca2+/mtDNA/cGAS-STING signaling cascade DOI Creative Commons

Kaihao Wang,

Yipeng Du,

Peixin Li

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 6, 2024

Abstract Background Nanoplastics (NPs) are now a new class of pollutants widely present in the soil, atmosphere, freshwater and marine environments. can rapidly penetrate cell membranes accumulate human tissues organs, thus posing potential threat to health. The heart is main power source body. But up now, toxicological effects long-term exposure nanoplastics on has not been revealed yet. Results We evaluated long term cardiac cell/tissue vitro vivo model. Furthermore, we explored molecular mechanism by which causes myocardial senescence. Immunohistochemistry, indirect immunofluorescence ELISA were performed detect aging. found that able induce significant aging through series biochemical assays vivo. In vitro, investigated, internalize into cardiomyocytes time dose-dependant manner. Further analysis showed induces senescence detecting marker molecules. Molecular research shows may cause mitochondrial destabilization inducing oxidative stress, leads leakage mtDNA from mitochondria cytoplasm, then cytoplasm-localized mt-DNA activates cGAS-STING signaling pathway promotes inflammation response, ultimately Conclusions this work, premature heart. Current also reveals cardiomyocyte This study laid foundation for further studying harm Graphical abstract

Language: Английский

Citations

19

Microplastics in drinking water: A review on methods, occurrence, sources, and potential risks assessment DOI
Ling Yang, Shichang Kang, Xi Luo

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 348, P. 123857 - 123857

Published: March 25, 2024

Language: Английский

Citations

18

Technological approaches for removal of microplastics and nanoplastics in the environment DOI
S. Mustapha, Jimoh Oladejo Tijani,

R. Elabor

et al.

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(2), P. 112084 - 112084

Published: Feb. 2, 2024

Language: Английский

Citations

17