PPIH acts as a potential predictive biomarker for patients with common solid tumors

BMC Cancer, Год журнала: 2024, Номер 24(1)

Опубликована: Июнь 4, 2024

Abstract Background Our previous studies have indicated that mRNA and protein levels of PPIH are significantly upregulated in Hepatocellular Carcinoma (LIHC) could act as predictive biomarkers for patients with LIHC. Nonetheless, the expression implications etiology progression common solid tumors yet to be explored, including its potential a serum tumor marker. Methods We employed bioinformatics analyses, augmented clinical sample evaluations, investigate gene regulation networks various tumors. also assessed association between overall survival (OS) cancer using Kaplan-Meier analysis TCGA database information. Furthermore, we evaluated feasibility diagnostic efficacy marker by integrating serological established markers. Results Through pan-cancer analysis, found multiple were different from those normal tissues. This study is first report markedly elevated LIHC, Colon adenocarcinoma (COAD), Breast (BC), associated worse prognosis these patients. Conversely, decreased (LIHC, COAD, BC, gastric cancer), when combined traditional markers, offer enhanced sensitivity specificity diagnosis. Conclusion findings propose may serve valuable biomarker patients, secreted marker, providing insights into role development progression.

Язык: Английский

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Immunotherapy of gastric cancer: Present status and future perspectives

World Journal of Gastroenterology, Год журнала: 2024, Номер 30(8), С. 779 - 793

Опубликована: Фев. 26, 2024

In this editorial, we comment on the article entitled "Advances and key focus areas in gastric cancer immunotherapy: A comprehensive scientometric clinical trial review (1999-2023)," which was published recent issue of

Язык: Английский

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Advancing gastric cancer treatment: nanotechnology innovations and future prospects

Cell Biology and Toxicology, Год журнала: 2024, Номер 40(1)

Опубликована: Ноя. 20, 2024

Gastric cancer (GC) is the fifth most common worldwide, particularly prevalent in Asia, especially China, where both its incidence and mortality rates are significantly high. Meanwhile, nanotechnology has demonstrated great potential treatment of GC. In particular, nanodrug delivery systems have improved therapeutic efficacy targeting through various functional modifications, such as peptides, tumor microenvironment responsiveness, instrument-based methods. For instance, silica (SiO2) excellent biocompatibility can be used a drug carrier, with porous structure enhancing loading capacity. Polymer nanoparticles regulate release mechanisms by altering material composition preparation Lipid efficiently encapsulate hydrophilic drugs promote cellular uptake, while carbon-based biosensors delivery. Targets integrins, HER2 receptors, been to improve GC treatment. Nanodrug techniques not only enhance capabilities but also selectively target cells. Currently, there lack systematic summarization synthesis regarding relationship between treatment, which some extent hinders researchers clinicians from searching for referencing related studies, thereby reducing work efficiency. This study aims systematically summarize existing research on making it easier professionals search reference, promoting further role their clinical applications review discusses functionalized nanocarriers recent years, including surface modifications targeted markers, combination phototherapy, chemotherapy, immunotherapy, along advantages challenges. It examines future prospects nanomaterials The focuses combined application multiple modalities, demonstrating multimodal treatments. Furthermore, thoroughly explores specific challenges that face biocompatibility, control, translation issues, providing outlook developments. Additionally, this emphasizes value feasibility applications, contrasting reviews focus basic research. Through these innovations, we offer new perspectives directions development

Язык: Английский

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Exploring the mediating role of blood metabolites in the relationship between gut microbiota and gastric cancer risk: a Mendelian randomization study

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 14

Опубликована: Янв. 7, 2025

Prior studies have established correlations between gut microbiota (GM) dysbiosis, circulating metabolite alterations, and gastric cancer (GC) risk. However, the causal nature of these associations remains uncertain. We utilized summary data from genome-wide association (GWAS) on GM (European, n=8,956), blood metabolites n=120,241; East Asian, n=4,435), GC n=476,116; n=167,122) to perform a bidirectional Mendelian randomization (MR) analysis, investigating effects Additionally, we conducted mediation analysis (two-step MR) identify potential mediators in GM-GC relationship. identified twelve negative seven positive specific taxa For metabolites, traits were found be significantly associated with reduced risk European population, findings subsequently validated Asian cohort. Three showed five metabolic traits: Bacteroidia class Bacteroidales order positively correlated (all P < 0.013), while Bacteroides OTU97_27 exhibited correlation one (P = 0.007). Two-step MR indicated that total lipids intermediate-density lipoprotein (IDL), IDL particle concentration, phospholipids medium low-density (LDL), small LDL, free cholesterol LDL indirectly influenced class/Bacteroidales GC, proportions 1.71% 0.048), 1.69% 2.05% 0.045), 1.85% 1.99% respectively. The present study provides suggestive evidence relationship GM, risk, potentially offering new insights into etiology.

Язык: Английский

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The artificial intelligence revolution in gastric cancer management: clinical applications

Cancer Cell International, Год журнала: 2025, Номер 25(1)

Опубликована: Март 21, 2025

Nowadays, gastric cancer has become a significant issue in the global burden, and its impact cannot be ignored. The rapid development of artificial intelligence technology is attempting to address this situation, aiming change clinical management landscape fundamentally. In transformative change, machine learning deep learning, as two core technologies, play pivotal role, bringing unprecedented innovations breakthroughs diagnosis, treatment, prognosis evaluation cancer. This article comprehensively reviews latest research status application algorithms cancer, covering multiple dimensions such image recognition, pathological analysis, personalized risk assessment. These applications not only significantly improve sensitivity monitoring, accuracy precision survival but also provide robust data support scientific basis for decision-making. integration intelligence, from optimizing diagnosis process enhancing diagnostic efficiency promoting practice medicine, demonstrates promising prospects reshaping treatment model Although most current AI-based models have been widely used practice, with continuous deepening expansion we reason believe that new era AI-driven care approaching.

Язык: Английский

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New approaches of chimeric antigen receptor (CAR)-immune cell-based therapy in gastric cancer; highlight CAR-T and CAR-NK

Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)

Опубликована: Март 25, 2025

Язык: Английский

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Advances in the protein‑encoding functions of circular RNAs associated with cancer (Review)

Oncology Reports, Год журнала: 2023, Номер 50(2)

Опубликована: Июль 10, 2023

Circular RNAs (circRNAs) are a special class of non‑coding that widely expressed in tissues and cells. Owing to their lack 5'‑cap 3'‑polyadenylated [poly(A)] tail, they more structurally stable difficult degrade compared with linear RNA. Numerous studies published recently have suggested circRNAs can encode peptides or proteins through cap‑independent translation mechanisms participate the occurrence development cancer. In present review, mechanism underlying encoding by circRNAs, biological information tools available for predicting translation, identification verification translational abilities summarized analyzed. Finally, associated circRNA‑encoded polypeptides various types cancer summarized. this review its discussion on coding function, we hope provide novel perspectives possibilities treatment as knowledge area is added developed future.

Язык: Английский

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Comparison of the Biomechanical Properties between Healthy and Whole Human and Porcine Stomachs

Bioengineering, Год журнала: 2024, Номер 11(3), С. 233 - 233

Опубликована: Фев. 28, 2024

Gastric cancer poses a societal and economic burden, prompting an exploration into the development of materials suitable for gastric reconstruction. However, there is dearth studies on mechanical properties porcine human stomachs. Therefore, this study was conducted to elucidate their properties, focusing interspecies correlations. Stress relaxation tensile tests assessed hyperelastic viscoelastic characteristics The thickness, stress–strain curve, elastic modulus, stress were assessed. Porcine stomachs significantly thicker than stiffness contrast between evident. demonstrated varying modulus values, with highest in longitudinal mucosa layer corpus lowest intact fundus. In stomachs, muscular antrum highest, whereas that circumferential muscularis lowest. degree higher This comprehensively elucidated differences attributable variations across different regions tissue layers, providing essential biomechanical support subsequent field.

Язык: Английский

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Integrated multi-omics analysis and machine learning identify hub genes and potential mechanisms of resistance to immunotherapy in gastric cancer

Aging, Год журнала: 2024, Номер unknown

Опубликована: Апрель 22, 2024

Background: Patients with gastric cancer respond poorly to immunotherapy. There are still unknowns about the biomarkers associated immunotherapy sensitivity and their underlying molecular mechanisms. Methods: Gene expression data for were gathered from TCGA GEO databases. DEGs response came ICBatlas. KEGG GO analyses investigated pathways. Hub genes identification employed multiple machine algorithms. Associations between hub signaling pathways, disease genes, immune cell infiltration, drug sensitivity, prognostic predictions explored via multi-omics analysis. gene was validated through HPA CCLE. Multiple algorithms pinpointed Cancer-Associated Fibroblasts (CAFs), ten machine-learning methods generating CAFs scores prognosis. Model at single-cell level using TISCH database. Results: We identified 201 upregulated 935 downregulated DEGs. Three namely CDH6, EGFLAM, RASGRF2, unveiled. These implicated in diverse disease-related Additionally, they exhibited significant correlations disease-associated expression, sensitivity. Exploration of CCLE databases exposed substantial variations across patients lines these genes. Subsequently, we CAFs-associated established a robust model. The analysis database showed that this model highly expressed CAFs. Conclusions: results unveil an association RASGRF2 immunotherapeutic cancer. hold potential as predictive resistance assessment.

Язык: Английский

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Tumor‐derived Prevotella intermedia aggravates gastric cancer by enhancing Perilipin 3 expression

Cancer Science, Год журнала: 2024, Номер 115(4), С. 1141 - 1153

Опубликована: Янв. 29, 2024

Abstract The indigenous microbial milieu within tumorous tissues exerts a pivotal influence on the genesis and advancement of gastric cancer (GC). This investigation scrutinizes functions molecular mechanisms attributed to Prevotella intermedia in malignant evolution GC. Isolation P. from paired GC was undertaken. Quantification abundance 102 accomplished using quantitative real‐time PCR (qRT‐PCR). Assessment biological effects cells observed culture medium supernatant. Furthermore, protein profile treated with tumor‐derived examined through label‐free analysis. functionality perilipin 3 (PLIN3) subsequently confirmed shRNA. Our revealed that relative tumor significantly surpassed corresponding healthy tissues. exhibited correlations differentiation ( p = 0.006), perineural invasion 0.004), omentum majus 0.040), survival duration patients 0.042). supernatant derived tumor‐associated bolstered proliferation, clone formation, migration, cells. After indirect co‐cultivation , dysregulation 34 proteins, including PLIN3, discerned Knockdown PLIN3 mitigated malignancy instigated by findings posit microenvironment plays substantial role progression via modulation expression. Moreover, might serve as potential biomarker for diagnosis prognosis

Язык: Английский

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