Digital Chinese Medicine, Год журнала: 2024, Номер 7(4), С. 365 - 387
Опубликована: Дек. 1, 2024
Язык: Английский
Phytomedicine Plus, Год журнала: 2025, Номер unknown, С. 100754 - 100754
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 6, 2025
Heracleum L. has been known as "hogweed" and used for inflammatory diseases, including fever, enteritis, bronchitis, many years worldwide. The genus is also prominently recognized its high content of coumarins, which are considered a significant group natural compounds their noteworthy anti-inflammatory properties. present study evaluated the activity dichloromethane methanolic extracts from H. paphlagonicum, sphondylium subsp. ternatum, elegans, cyclocarpum (100 mg/kg), have not previously investigated Inflammation models induced by carrageenan, prostaglandin E2, serotonin were employed to evaluate activity, using indomethacin (10 mg/kg) reference standard. Statistical differences between treatment control groups ANOVA with Student-Newman-Keuls post-hoc tests. Additionally, coumarin contents quantified mg/g high-performance liquid chromatography. roots displayed highest inhibition serotonin-induced hind paw edema, ranges 22.8%-36.9%, 5.4%-35.7%, 3.9%-17.9%, respectively, while 12.8%-44.3%, 2.7%-41.3%, 7.1%-30.6%, respectively. bergapten imperatorin quantities found in (0.49% 0.14%) elegans roots, had xanthotoxin level (0.06%). Angelicin was detected at concentrations 0.04%, 0.02%, correlation inhibitory observed elevated levels particularly imperatorin, suggests potential link concentration effects. our findings support traditional use this treating disorders. Further investigations necessary identify active elucidate mechanisms action these plants, potentially leading discovery novel therapeutic options inflammation.
Язык: Английский
Процитировано
1
Phytomedicine Plus, Год журнала: 2025, Номер unknown, С. 100785 - 100785
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Processes, Год журнала: 2025, Номер 13(2), С. 300 - 300
Опубликована: Янв. 22, 2025
The extraction of bioactive compounds, such as flavonoids and coumarins, from natural sources has gained significant attention due to their potential health benefits. This review aims explore the application high-pressure processes, particularly supercritical fluid (SFE) pressurized liquid (PLE), for obtaining coumarins flower seeds. These techniques offer a greener, more efficient alternative conventional methods, minimizing use harmful solvents improving yield purity target compounds. Flower seeds, rich source molecules, are an underutilized reservoir these valuable For example, seeds plants Calendula officinalis (calendula) Helianthus annuus (sunflower) in coumarins. proposed will examine influence parameters—such temperature, pressure, solvent choice, time—on quality provide comprehensive understanding methods optimize protocols efficient, sustainable
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2025, Номер unknown, С. e42753 - e42753
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(7), С. 1423 - 1423
Опубликована: Март 23, 2025
Phenolic compounds, with their diverse biological activities, are widely explored as cosmetic ingredients photoprotective, antioxidant, anti-inflammatory, and anti-hyperpigmentation properties, offering a multitargeted approach to combat photo-induced skin aging. The study analyzed 1299 products from 2021 2024 understand the market impact of phenolic compounds mechanism action against damage. A total 28 active were identified prevalence phenolics was 13.2% in anti-aging products, 5.2% sunscreens 4.8% aftersun products. Bakuchiol polyphenols, such resveratrol, chrysin, hesperidin methyl chalcone, found Sunscreens counted ferulic caffeic acids, salicylic acid, respectively. Antioxidant activity be primary by scavenging reactive species, thus mitigating oxidative stress. Ferulic glucosylrutin can also absorb UV radiation, acting preventively solar-induced This provides insights into limited use commercial cosmetics, despite suggests potential barriers wider sun care
Язык: Английский
Процитировано
0
Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142149 - 142149
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
ChemistrySelect, Год журнала: 2025, Номер 10(16)
Опубликована: Апрель 1, 2025
Abstract Coumarin (2‐benzopyrone), a secondary plant metabolite, is considered privileged scaffold in medicinal chemistry. and its derivatives have been demonstrated to exhibit various biological activities such as antiviral, antibacterial, anticancer, anti‐inflammatory, anticonvulsant, antioxidant, antidepressant, anti‐Alzheimer, antidiabetic. Because of wide spectrum activities, it has explored extensively which resulted the development many clinically useful drug molecules. Attempts made prepare coumarin by either substituting them with variety aromatic heterocyclic rings functionalities or preparing hybrids linked through an appropriate linker obtain develop potential therapeutic agents. The inclusion natural metabolites gained importance recent past enhance activity. moieties are easily synthesized chemical methods Knoevenagel reaction, Pechmann condensation, Kostanecki–Robinson coupling Claisen rearrangement, Michel addition Witting Reformatsky Perkin so on. current review provides overview classification coumarins, details approaches used for synthesis derivatives. introduced synthetic compounds discussed structure‐activity relationship (SAR) supported their 2D molecular docking studies interaction within receptors. SAR will support chemist directing novel diverse pharmacological properties.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12421 - 12421
Опубликована: Ноя. 19, 2024
Vitiligo is a skin condition characterized by the loss of pigment, resulting in white patches on various parts body. It occurs when melanocytes, cells that are responsible for producing destroyed or stop functioning. This study aimed to investigate melanogenic potential 4-methylcoumarin (4MC) derivatives, including 6-methoxy-4-methylcoumarin (6M-4MC), 7-methoxy-4-methylcoumarin (7M-4MC), 7-amino-4-methylcoumarin (7A-4MC), 6,7-dihydroxy-4-methylcoumarin (6,7DH-4MC), 7,8-dihydroxy-4-methylcoumarin (7,8DH-4MC), and 6,7-dimethoxy-4-methylcoumarin (6,7DM-4MC), B16F10 melanoma cells. Our findings revealed that, while 4MC, 7A-4MC, 6,7DH-4MC, 7,8DH-4MC did not exhibit any effect melanin production, significant stimulation melanogenesis was observed with 6M-4MC, 7M-4MC, 6,7DM-4MC, 6M-4MC demonstrating most pronounced effect. significantly stimulated production tyrosinase activity concentration-dependent manner A Western blot analysis increased expression levels microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein-1 (TRP-1), protein-2 (TRP-2). Further mechanistic studies showed inhibited extracellular signal-regulated kinase (ERK) protein B (AKT), which led upregulation MITF TRP proteins subsequent activation synthesis. Additionally, activated GSK3β phosphorylation, reduced β-catenin via GSK3β/β-catenin pathway. Moreover, primary irritation test conducted upper backs 32 healthy female volunteers assess sensitization from applied topically at concentrations 50 µM 100 µM. The results no adverse effects skin. Collectively, these suggest may be promising pigmentation stimulator use cosmetics medical treatment hypopigmentation disorders, particularly conditions such as vitiligo.
Язык: Английский
Процитировано
3
Healthcare, Год журнала: 2024, Номер 12(24), С. 2520 - 2520
Опубликована: Дек. 12, 2024
Background: Behavioral factors, such as smoking, alcohol consumption, stress, poor diet, and physical inactivity, but also sleep deprivation negative social connections, play a critical role in the development progression of major chronic diseases. These include cardiovascular diseases, diabetes, respiratory conditions, cancers. Methods: The objective this review is to explore influence these modifiable risk factors on global burden diseases assess potential impact public health interventions policy changes. Results: evidence highlights significant association between behavioral increased morbidity mortality from Public changes targeting behaviors have shown substantial reducing prevalence conditions. Strategies smoking cessation programs, dietary improvements, activity promotion, stress reduction are mitigating risks. Conclusions: Addressing essential for prevention control Bridging gap current knowledge effective implementation crucial improving population outcomes. strategies focused modifying key risks can significantly reduce thereby overall healthcare costs.
Язык: Английский
Процитировано
1