Pharmaceutics,
Год журнала:
2021,
Номер
13(2), С. 198 - 198
Опубликована: Фев. 2, 2021
Some
issues
in
pharmaceutical
therapies
such
as
instability,
poor
membrane
permeability,
and
bioavailability
of
drugs
can
be
solved
by
the
design
suitable
delivery
systems
based
on
combination
two
pillar
classes
ingredients:
polymers
lipids.
At
same
time,
modern
technologies
are
required
to
overcome
production
limitations
(low
productivity,
high
energy
consumption,
expensive
setup,
long
process
times)
pass
at
industrial
level.
In
this
paper,
a
summary
applications
polymeric
lipid
materials
combined
nanostructures
(hybrid
nanocarriers)
is
reported.
Then,
recent
techniques
adopted
hybrid
nanoparticles
discussed,
highlighting
still
present
that
hold
back
implementation.
Advanced Materials,
Год журнала:
2022,
Номер
35(12)
Опубликована: Авг. 23, 2022
Hollow-structured
nanomaterials
(HSNMs)
have
attracted
increased
interest
in
biomedical
fields,
owing
to
their
excellent
potential
as
drug
delivery
systems
(DDSs)
for
clinical
applications.
Among
HSNMs,
hollow
multi-shelled
structures
(HoMSs)
exhibit
properties
such
high
loading
capacity,
sequential
release,
and
multi-functionalized
modification
represent
a
new
class
of
nanoplatforms
The
remarkable
HoMS-based
DDS
can
simultaneously
satisfy
enhance
DDSs
delivering
small
molecular
drugs
(e.g.,
antibiotics,
chemotherapy
drugs,
imaging
agents)
macromolecular
protein/peptide-
nucleic
acid-based
drugs).
First,
the
latest
research
advances
are
summarized
highlight
inherent
advantages
targeting,
combining
continuous
therapeutic
theranostics
optimize
benefit.
Meanwhile,
initial
development
stage
currently
offer
limited
modes.
There
is
growing
need
analyze
deficiency
other
HSNMs
integrate
providing
solutions
safe,
stable,
cascade
meet
vast
treatment
requirements.
Therefore,
comprehensively
reviewed,
mainly
focusing
on
characteristics,
progress
by
category,
future
prospects.
Theranostics,
Год журнала:
2021,
Номер
12(2), С. 689 - 719
Опубликована: Дек. 15, 2021
Ischemic
stroke
(IS)
is
one
of
the
leading
causes
death
and
disability
resulting
in
inevitable
burden
globally.
injury
initiates
cascade
pathological
events
comprising
energy
dwindling,
failure
ionic
gradients,
blood
brain
barrier
(BBB),
vasogenic
edema,
calcium
over
accumulation,
excitotoxicity,
increased
oxidative
stress,
mitochondrial
dysfunction,
inflammation
eventually
cell
death.
In
spite
such
complexity
disease,
only
treatment
approved
by
US
Food
Drug
Administration
(FDA)
tissue
plasminogen
activator
(t-PA).
This
therapy
overcome
deficiency
along
with
side
effects
reperfusion
which
are
responsible
for
considerable
injury.
Therefore,
there
urgent
need
novel
therapeutic
perspectives
that
can
protect
integrity
BBB
salvageable
tissue.
Advancement
nanomedicine
empowering
new
approaches
potent
to
improve
understanding
IS.
Herein,
we
focus
nanomaterial
mediated
drug
delivery
systems
(DDSs)
their
role
bypass
cross
especially
via
intranasal
delivery.
The
various
nanocarriers
used
DDSs
also
discussed.
a
nut
shell,
objective
provide
an
overview
use
diagnosis
IS
facilitate
research
from
benchtop
bedside.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2022,
Номер
10
Опубликована: Июль 19, 2022
Nanogels
have
come
out
as
a
great
potential
drug
delivery
platform
due
to
its
prominently
high
colloidal
stability,
loading,
core-shell
structure,
good
permeation
property
and
can
be
responsive
environmental
stimuli.
Such
nanoscopic
carriers
more
excellent
abilities
over
conventional
nanomaterials
for
permeating
brain
parenchyma
Pharmaceutics,
Год журнала:
2022,
Номер
14(9), С. 1870 - 1870
Опубликована: Сен. 5, 2022
Central
nervous
system
(CNS)
disorders,
such
as
psychiatric
neurodegeneration,
chronic
pain,
stroke,
brain
tumor,
spinal
cord
injury,
and
many
other
CNS
diseases,
would
hugely
benefit
from
specific
potent
peptide
pharmaceuticals
their
low
inherent
toxicity.
The
delivery
of
peptides
to
the
is
challenging
due
metabolic
stability,
which
decreases
duration
action,
poor
penetration
blood-brain
barrier
(BBB),
incompatibility
with
oral
administration,
typically
resulting
in
need
for
parenteral
administration.
These
challenges
limit
peptides'
clinical
application
explain
interest
alternative
routes
particularly
nose-to-brain
(N-to-B)
delivery,
allows
protein
drugs
reach
noninvasively.
N-to-B
can
be
a
convenient
method
rapidly
targeting
CNS,
bypassing
BBB,
minimizing
systemic
exposure;
olfactory
trigeminal
nerves
provide
unique
pathway
external
environment.
This
review
highlights
intranasal
drugs,
focusing
on
illustrating
various
applications,
nasal
devices,
scope
limitations
this
approach.
Polymers,
Год журнала:
2023,
Номер
15(23), С. 4563 - 4563
Опубликована: Ноя. 28, 2023
Polymeric
drug
delivery
technology,
which
allows
for
medicinal
ingredients
to
enter
a
cell
more
easily,
has
advanced
considerably
in
recent
decades.
Innovative
medication
strategies
use
biodegradable
and
bio-reducible
polymers,
progress
the
field
been
accelerated
by
future
possible
research
applications.
Natural
polymers
utilized
polymeric
systems
include
arginine,
chitosan,
dextrin,
polysaccharides,
poly(glycolic
acid),
poly(lactic
hyaluronic
acid.
Additionally,
poly(2-hydroxyethyl
methacrylate),
poly(N-isopropyl
acrylamide),
poly(ethylenimine),
dendritic
bioabsorbable
as
well
biomimetic
bio-related
drug-free
macromolecular
therapies
have
employed
delivery.
Different
synthetic
natural
biomaterials
are
clinical
phase
mitigate
different
diseases.
Drug
methods
using
becoming
increasingly
common
pharmaceutical
industry,
with
biocompatible
copolymers
dendrimers
having
helped
cure
cancer
systems.
This
review
discusses
all
above
components
how,
combining
biological
approaches,
micro-
nano-drug
can
result
revolutionary
gene
devices.
Pharmaceutics,
Год журнала:
2023,
Номер
15(1), С. 205 - 205
Опубликована: Янв. 6, 2023
Therapeutic
proteins,
including
monoclonal
antibodies,
single
chain
variable
fragment
(ScFv),
crystallizable
(Fc),
and
antigen
binding
(Fab),
have
accounted
for
one-third
of
all
drugs
on
the
world
market.
In
particular,
these
medicines
been
widely
used
in
ocular
therapies
treatment
various
diseases,
such
as
age-related
macular
degeneration,
corneal
neovascularization,
diabetic
retinopathy,
retinal
vein
occlusion.
However,
formulation
biomacromolecules
is
challenging
due
to
their
high
molecular
weight,
complex
structure,
instability,
short
half-life,
enzymatic
degradation,
immunogenicity,
which
leads
failure
therapies.
Various
efforts
made
overcome
barriers,
providing
effective
delivery
therapeutic
altering
protein
structure
or
it
new
systems.
These
strategies
are
not
only
cost-effective
beneficial
patients
but
also
shown
allow
fewer
drug
side
effects.
this
review,
we
discuss
several
factors
that
affect
design
formulations
proteins
tissues,
use
injectable
micro/nanocarriers,
hydrogels,
implants,
iontophoresis,
cell-based
therapy,
combination
techniques.
addition,
other
approaches
briefly
discussed,
related
structural
modification
improving
bioavailability
posterior
segments
eye
without
affecting
stability.
Future
research
should
be
conducted
toward
development
more
effective,
stable,
noninvasive,
proteins.
insights
into
preclinical
clinical
translation
needed.
Scientific Reports,
Год журнала:
2020,
Номер
10(1)
Опубликована: Июль 2, 2020
Abstract
As
synthetic
antioxidants
that
are
widely
used
in
foods
known
to
cause
detrimental
health
effects,
studies
on
natural
additives
as
potential
becoming
increasingly
important.
In
this
work,
the
total
phenolic
content
(TPC)
and
antioxidant
activity
of
Ficus
carica
Linn
latex
from
18
cultivars
were
investigated.
The
TPC
was
calculated
using
Folin–Ciocalteu
assay.
1,1-Diphenyl-2-picrylhydrazyl
(DPPH),
2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic
acid)
(ABTS)
ferric
ion
reducing
power
(FRAP)
for
assessment.
bioactive
compounds
F.
extracted
via
maceration
ultrasound-assisted
extraction
(UAE)
with
75%
ethanol
solvent.
Under
same
conditions,
cultivar
‘White
Genoa’
showed
highest
65.91%
±
1.73%
61.07%
1.65%
DPPH,
98.96%
1.06%
83.04%
2.16%
ABTS,
27.08
0.34
24.94
0.84
mg
TE/g
FRAP
assay
UAE,
respectively.
315.26
6.14
298.52
9.20
µg
GAE/mL
two
methods,
overall
results
work
is
a
source
antioxidants.
This
finding
useful
further
advancements
fields
food
supplements,
drug
synthesis
future.
