Designing
and
synthesizing
multishelled
metallic
hollow
nanostructures
with
intragaps
porous
shells
have
received
widespread
attention
for
enhancing
optical
catalytic
properties.
However,
significant
challenges
remain
in
engineering
these
structures
at
the
nanometer
scale.
Herein,
we
employed
galvanic
replacement
reaction
(GRR)
method
to
prepare
multimetallic
superstructures
3D
cavities
distinct
intragaps.
By
precise
control
of
intragap
distances
(1–10
nm)
composition
distributions
within
a
single
entity,
libraries
were
constructed.
Using
4-nitrophenol
reduction
as
model
reaction,
triple-shell
Au@Pt–Ag
nanoparticles
approximately
1
nm
exhibited
rate
211.6
times
higher
than
that
commercial
Pt/C
catalysts.
The
nanoconfinement
environment
not
only
increases
active
sites
but
also
promotes
electron
delocalization
reactants,
accelerating
hydrogenation
process
both
thermodynamically
kinetically.
Our
work
advances
rational
synthesis
nanostructures,
expanding
their
potential
applications
catalysis,
plasmonics,
biosensing.
Abstract
Tumor
immunotherapy
exerts
its
anti-tumor
effects
by
stimulating
and
enhancing
immune
responses
of
the
body.
It
has
become
another
important
modality
therapy
with
significant
clinical
efficacy
advantages
compared
to
chemotherapy,
radiotherapy
targeted
therapy.
Although
various
kinds
tumor
immunotherapeutic
drugs
have
emerged,
challenges
faced
in
delivery
these
drugs,
such
as
poor
permeability
low
cell
uptake
rate,
had
prevented
their
widespread
application.
Recently,
nanomaterials
emerged
a
means
for
treatment
different
diseases
due
targeting
properties,
biocompatibility
functionalities.
Moreover,
possess
characteristics
that
overcome
defects
traditional
immunotherapy,
large
drug
loading
capacity,
precise
easy
modification,
thus
leading
wide
application
immunotherapy.
There
are
two
main
classes
novel
nanoparticles
mentioned
this
review:
organic
(polymeric
nanomaterials,
liposomes
lipid
nanoparticles)
inorganic
(non-metallic
metallic
nanomaterials).
Besides,
fabrication
method
nanoparticles,
Nanoemulsions,
was
also
introduced.
In
summary,
review
article
mainly
discussed
research
progress
based
on
past
few
years
offers
theoretical
basis
exploring
strategies
future.
Cell Reports Physical Science,
Год журнала:
2024,
Номер
5(7), С. 102097 - 102097
Опубликована: Июль 1, 2024
The
rapid
development
of
intelligent
devices
imposes
new
demands
on
electromagnetic
wave
(EMW)-absorbing
materials,
especially
concerning
wide-spectrum
absorption,
frequency
band
manipulation,
and
multifunctional
integration.
However,
conventional
investigations
EMW-absorbing
materials
face
several
challenges
that
collectively
limit
the
effectiveness
existing
amid
growing
demands,
including
ambiguous
(EM)
loss
mechanisms,
impedance
mismatches,
deficiencies
in
integrated
design.
This
review
elucidates
EM
delineates
key
bridge
mechanisms
linking
microscopic
macroscopic
factors,
proposes
dielectric
polarization
models
to
clarify
mechanisms.
Additionally,
it
delves
into
unique
advantages
core-shell
structures
porous
optimization.
Finally,
introduces
fabrication
approaches
integrate
detailing
design
strategies
exploring
potential
applications.
By
consolidating
these
cutting-edge
achievements,
this
aims
guide
scientific
advancement
materials.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(1)
Опубликована: Сен. 6, 2023
Core-shell
structured
nanocarriers
have
come
into
the
scientific
spotlight
in
recent
years
due
to
their
intriguing
properties
and
wide
applications
materials
chemistry,
biology,
biomedicine.
Tailored
core-shell
structures
achieve
desired
performance
emerged
as
a
research
frontier
development
of
smart
drug
delivery
system.
However,
systematic
reviews
on
design
loading/release
mechanisms
stimulus-responsive
are
uncommon.
This
review
starts
with
categories
different
means
payload,
then
highlights
controlled
release
mechanism
realized
through
stimulus-response
processes
triggered
under
environments.
Finally,
some
multifaceted
perspectives
carriers
addressed.
work
aims
provide
new
enlightenments
prospects
field
for
further
developing
advanced
nanocarriers.
Advanced Materials,
Год журнала:
2023,
Номер
36(7)
Опубликована: Ноя. 10, 2023
Designing
an
effective
treatment
strategy
to
combat
oral
diseases
caused
by
complex
polymicrobial
biofilms
remains
a
great
challenge.
Herein,
series
of
metal-phenolic
network
with
Pd
nanoparticle
nodes
using
polyphenols
as
stabilizers
and
reducing
agents
is
constructed.
Among
them,
sulfonated
lignin-Pd
(SLS-Pd)
ultrafine
size
palladium
nanoparticles
broadband
near
infrared
absorption
exhibit
excellent
oxidase-like
activity
stable
photothermal
effect.
In
vitro
experiments
demonstrate
that
the
superoxide
radical
generated
SLS-Pd
exhibits
selective
antibacterial
effects,
while
its
effect
induced
hyperthermia
potent
antifungal
properties.
This
difference
further
elucidated
RNA-sequencing
analysis
all-atom
simulation.
Moreover,
SLS-Pd-mediated
synergistic
antimicrobial
system
remarkable
efficacy
in
combating
various
biofilms.
By
establishing
root
canal
model
oropharyngeal
candidiasis
model,
feasibility
treating
biofilm-related
infections
validated.
provides
promising
therapeutic
approach
for
biofilm-associated
cavity.
Advanced Materials,
Год журнала:
2024,
Номер
36(18)
Опубликована: Янв. 15, 2024
Abstract
Mitochondria,
widely
known
as
the
energy
factories
of
eukaryotic
cells,
have
a
myriad
vital
functions
across
diverse
cellular
processes.
Dysfunctions
within
mitochondria
serve
catalysts
for
various
diseases,
prompting
widespread
demise.
Mounting
research
on
remedying
damaged
indicates
that
constitute
valuable
target
therapeutic
intervention
against
diseases.
But
less
clinical
practice
and
lower
recovery
rate
imply
limitation
traditional
drugs,
which
need
further
breakthrough.
Nanotechnology
has
approached
favorable
regiospecific
biodistribution
high
efficacy
by
capitalizing
excellent
nanomaterials
targeting
drug
delivery.
Mitochondria‐remedying
nanodrugs
achieved
ideal
effects.
This
review
elucidates
significance
in
cells
organs,
while
also
compiling
mortality
data
related
Correspondingly,
nanodrug‐mediate
strategies
applicable
mitochondria‐remedying
disease
are
detailed,
with
full
understanding
roles
dysfunction
advantages
nanodrugs.
In
addition,
future
challenges
directions
discussed.
conclusion,
this
provides
comprehensive
insights
into
design
development
nanodrugs,
aiming
to
help
scientists
who
desire
extend
their
fields
engage
interdisciplinary
subject.
Advanced Materials,
Год журнала:
2024,
Номер
36(24)
Опубликована: Март 19, 2024
Abstract
The
introduction
of
glucose
oxidase,
exhibiting
characteristics
consumption
and
H
2
O
production,
represents
an
emerging
antineoplastic
therapeutic
approach
that
disrupts
nutrient
supply
promotes
efficient
generation
reactive
oxygen
species
(ROS).
However,
the
instability
natural
enzymes
their
low
efficacy
significantly
impede
broader
application.
In
this
context,
2D
Ca
Mn
8
16
nanosheets
(CMO
NSs)
designed
engineered
to
serve
as
a
high‐performance
nanozyme,
enhancing
enzyodynamic
effect
for
ferroptosis–apoptosis
synergistic
tumor
therapy,
are
presented.
addition
mimicking
activities
glutathione
peroxidase,
catalase,
CMO
NSs
exhibit
oxidase‐mimicking
activities.
This
feature
contributes
antitumor
performance
through
cascade
catalytic
reactions,
involving
disruption
supply,
self‐supply
,
subsequent
ROS
generation.
exogenous
2+
released
from
NSs,
along
with
endogenous
enrichment
induced
by
peroxidase‐
collectively
mediate
overload,
leading
apoptosis.
Importantly,
ferroptosis
process
is
triggered
synchronously
output
consumption.
application
ultrasound
stimulation
further
enhances
efficiency
treatment.
work
underscores
crucial
role
in
therapy
against
tumors.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 6, 2025
Breast
cancer
(BC)
is
a
significant
cause
of
cancer-related
deaths
among
women
worldwide.
Hypoxia,
common
feature
solid
tumor,
associated
with
drug
resistance
and
poor
prognosis
in
BC.
In
this
study,
we
present
strategy
to
overcome
hypoxia-induced
chemotherapy
tolerance
Specifically,
synthesized
hollow
gold
(Au)-platinum
(Pt)
bimetallic
nanoshell
for
the
first
time,
which
acted
as
delivery
system
(DDS)
doxorubicin
(DOX).
The
photothermal
effect,
induced
by
surface
plasmon
resonance
(SPR)
from
Au-Pt
shell
under
near
infrared-II
(NIR-II)
laser
irradiation,
not
only
directly
causes
tumor
cell
death
through
therapy
(PTT),
but
also
significantly
enhances
catalase-like
activity
between
Pt
nanoparticles
endogenous
H2O2.
This,
subsequently,
results
heightened
yield
O2,
further
facilitates
release
DOX.
This
process
alleviates
hypoxia
down-regulating
hypoxia-inducible
factor-1α
(HIF-1α),
multidrug
gene
1
(MDR1),
P-glycoprotein
(P-gp),
can
reverse
achieve
more
effective
DOX
effects.
Significantly,
increased
availability
oxygen
re-polarizes
immunosuppressive
M2
macrophages
into
antitumor
M1
macrophages.
study
presents
novel
tackle
proliferation
enhance
response
chemotherapy,
offering
hope
reversing
cancerous
lesions.
Advanced Materials,
Год журнала:
2023,
Номер
36(3)
Опубликована: Ноя. 16, 2023
Lung
cancer
is
the
second
most
prevalent
and
leading
cause
of
cancer-related
death
worldwide.
Surgery,
chemotherapy,
molecular
targeted
therapy,
immunotherapy,
radiotherapy
are
currently
available
as
treatment
methods.
However,
drug
resistance
a
significant
factor
in
failure
lung
treatments.
Novel
therapeutics
have
been
exploited
to
address
complicated
mechanisms
advancement
nanomedicine
extremely
promising
terms
overcoming
resistance.
Nanomedicine
equipped
with
multifunctional
tunable
physiochemical
properties
alignment
tumor
genetic
profiles
can
achieve
precise,
safe,
effective
while
minimizing
or
eradicating
cancer.
Here,
this
work
reviews
discovered
for
radiotherapy,
outlines
novel
strategies
development
against
This
focuses
on
engineering
design,
customized
delivery,
current
challenges,
clinical
translation
application
resistant
