Biotechnology for Biofuels and Bioproducts,
Год журнала:
2023,
Номер
16(1)
Опубликована: Фев. 19, 2023
Microalgae
represent
a
suitable
and
eco-sustainable
resource
for
human
needs
thanks
to
their
fast
growth
ability,
together
with
the
great
diversity
in
species
intracellular
secondary
bioactive
metabolites.
These
high-added-value
compounds
are
of
interest
health
or
animal
feed.
The
content
these
valuable
compound
families
is
tightly
associated
microalgal
biological
state
responds
environmental
cues,
e.g.,
light.
Our
study
develops
Biotechnological
response
curve
strategy
exploring
metabolites
synthesis
marine
cyanobacterium
Spirulina
subsalsa
over
light
energy
gradient.
Relative
Light
index
generated
our
integrates
red,
green
blue
photon
flux
density
relative
energy.
combined
biochemical
analysis
macromolecular
composition
(total
protein,
lipid,
carbohydrate
content),
total
sterols,
polyphenols
flavonoids,
carotenoids,
phenolic
compounds,
vitamins
(A,
B1,
B2,
B6,
B9,
B12,
C,
D2,
D3,
E,
H,
K1),
phycobiliproteins,
antioxidant
activity
biomass
as
well
ability
photosynthesis.Results
demonstrated
that
significantly
modulate
status
microalga
revealing
relevance
explain
light-induced
variability.
sharp
decrease
photosynthetic
rate
at
high
was
accompanied
an
increase
network
response,
such
polyphenols,
capacity.
Conversely,
low
favorized
lipids
(B2,
K1,
A,
B12)
compared
energy.Results
curves
were
discussed
functional
physiological
essence
potential
biotechnological
applications.
This
emphasized
relevant
tool
responses
microalgae
towards
climate
variability,
and,
therefore,
design
metabolic
manipulation
microalgae.
Metabolites,
Год журнала:
2023,
Номер
13(8), С. 895 - 895
Опубликована: Июль 28, 2023
Secondary
metabolites
are
gaining
an
increasing
importance
in
various
industries,
such
as
pharmaceuticals,
dyes,
and
food,
is
the
need
for
reliable
efficient
methods
of
procuring
these
compounds.
To
develop
sustainable
cost-effective
approaches,
a
comprehensive
understanding
biosynthetic
pathways
factors
influencing
secondary
metabolite
production
essential.
These
compounds
unique
type
natural
product
which
recognizes
oxidative
damage
caused
by
stresses,
thereby
activating
defence
mechanism
plants.
Various
have
been
developed
to
enhance
The
elicitor-induced
vitro
culture
technique
considered
tool
studying
improving
In
present
review,
we
documented
role
under
diverse
environmental
stresses.
Furthermore,
practical
strategy
obtaining
consistent
abundant
via
elicitation
agents
used
culturing
techniques
also
mentioned.
By
elucidating
intricate
interplay
regulatory
factors,
this
review
paves
way
future
advancements
high-value
metabolites.
Molecules,
Год журнала:
2022,
Номер
27(24), С. 8852 - 8852
Опубликована: Дек. 13, 2022
Microalgae
are
photosynthetic,
eukaryotic
organisms
that
widely
used
in
the
industry
as
cell
factories
to
produce
valuable
substances,
such
fatty
acids
(polyunsaturated
(PUFAs)
eicosapentaenoic
acid
(EPA)
and
docosahexaenoic
(DHA)),
sterols
(sitosterol),
recombinant
therapeutic
proteins,
carbohydrates,
vitamins,
phenolic
compounds
(gallic
acid,
quercetin),
pigments
(β-carotene,
astaxanthin,
lutein).
Phenolic
carotenoids,
including
those
extracted
from
microalgae,
possess
beneficial
bioactivities
antioxidant
capacity,
antimicrobial
immunomodulatory
activities,
direct
health-promoting
effects,
which
may
alleviate
oxidative
stress
age-related
diseases,
cardiovascular
diseases
or
diabetes.
The
production
of
microalgal
metabolites
can
be
modified
by
using
abiotic
stressors,
light,
salinity,
nutrient
availability,
xenobiotics
(for
instance,
phytohormones).
World Journal of Microbiology and Biotechnology,
Год журнала:
2024,
Номер
40(9)
Опубликована: Июль 20, 2024
Microalgae
are
a
source
of
wide
variety
commodities,
including
particularly
valuable
pigments.
The
typical
pigments
present
in
microalgae
the
chlorophylls,
carotenoids,
and
phycobiliproteins.
However,
other
types
pigments,
family
water-soluble
polyphenols,
usually
encountered
terrestrial
plants,
have
been
recently
reported
microalgae.
Among
such
microalgal
many
flavonoids
yellowish
hue,
used
as
natural
textile
dyes.
Besides
being
colorants,
for
example
food
or
cosmetic
industry,
also
possess
bioactive
properties,
making
them
functional
nutraceutical
pharmaceutical
agents.
Each
type
pigment,
with
its
own
chemical
structure,
fulfills
particular
biological
functions.
Considering
both
eukaryotes
prokaryotes,
some
species
within
four
most
promising
groups
(Cyanobacteria,
Rhodophyta,
Chlorophyta
Heterokontophyta)
distinguished
by
their
high
contents
specific
added-value
To
further
enhance
pigment
during
autotrophic
cultivation,
review
is
made
main
related
strategies
adopted
last
decade,
light
adjustments
(quantity
quality,
duration
photoperiod
cycle),
regard
to
mineral
medium
characteristics
(salinity,
nutrients
concentrations,
presence
inductive
chemicals).
In
contrast
what
observed
growth-related
accumulation
non-photosynthetic
(polyphenols
secondary
carotenoids)
requires
stressful
conditions.
Finally,
enrichment
possible
two
new
cutting-edge
technologies,
via
application
metallic
nanoparticles
magnetic
fields.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Окт. 26, 2023
Microalgae,
as
photosynthetic
organisms,
have
the
potential
to
produce
biomolecules
for
use
in
food,
feed,
cosmetics,
nutraceuticals,
fuel,
and
other
applications.
Faster
growth
rates
higher
protein
lipid
content
make
microalgae
a
popular
chassis
many
industrial
However,
challenges
such
low
productivity
high
production
costs
limited
their
commercialization.
To
overcome
these
challenges,
bioengineering
approaches
genetic
engineering,
metabolic
synthetic
biology
been
employed
improve
quality
of
microalgae-based
products.
Genetic
engineering
employing
genome
editing
tools
like
CRISPR/Cas
allows
precise
targeted
modifications.
systems
are
presently
used
modify
makeup
enhanced
specific
biomolecules.
yet
be
explored
explicitly
owing
some
limitations.
Despite
progress
made
CRISPR-based
approaches,
there
is
still
need
further
research
optimize
This
includes
improving
efficiency
tools,
understanding
regulatory
mechanisms
microalgal
metabolism,
optimizing
conditions
cultivation
strategies.
Additionally,
addressing
ethical,
social,
environmental
concerns
associated
with
modification
crucial
responsible
development
commercialization
review
summarizes
advancements
industrially
important
provides
key
considerations
microalgae.
The
will
help
researchers
understand
initiate
experiments
Foods,
Год журнала:
2023,
Номер
12(14), С. 2652 - 2652
Опубликована: Июль 10, 2023
In
order
to
rapidly
screen
microalgae
species
as
feedstocks
for
antioxidants,
extracts
were
obtained
from
16
strains
(under
11
genera,
7
classes)
using
two
methods:
a
one-step
extraction
with
ethanol/water
and
three-step
fractionating
procedure
hexane,
ethylacetate,
water
successively.
Measuring
the
total
phenol
content
(TPC),
carotenoid
(TCC),
antioxidant
activity
of
extracts,
indicating
TPC
TCC,
played
an
important
role
in
determining
microalgae.
A
weighted
scoring
system
was
used
evaluate
activity,
scores
microalgal
samples
methods
calculated
same
system.
Among
investigated
microalgae,
Euglena
gracilis
SCSIO-46781
had
highest
score,
contributing
high
followed
by
Arthrospira
platensis
SCSIO-44012,
Nannochloropsis
sp.
SCSIO-45224,
Phaeodactylum
tricornutum
SCSIO-45120,
SCSIO-45006,
respectively.
Additionally,
above-mentioned
five
are
currently
being
applied
commercial
production,
this
could
be
effective
not
only
screening
but
also
species/strains
strong
adaptation
environmental
stress,
which
is
critical
trait
their
cultivation.
