Cuproptosis-associated ncRNAs predict breast cancer subtypes DOI Creative Commons
Qing Xia, Jinze Shen,

Qurui Wang

и другие.

PLoS ONE, Год журнала: 2024, Номер 19(2), С. e0299138 - e0299138

Опубликована: Фев. 26, 2024

Background Cuproptosis is a novel copper-dependent mode of cell death that has recently been discovered. The relationship between Cuproptosis-related ncRNAs and breast cancer subtypes, however, remains to be studied. Methods aim this study was construct subtype prediction model associated with Cuproptosis. This could used determine the patients. To achieve aim, 21 genes were obtained from published articles correlation analysis performed differentially expressed in cancer. Random forest algorithms subsequently utilized select important build models. Results A total 94 significantly top five essential features chosen predictive model. These biomarkers subtypes closely immune infiltration, RNA modification, angiogenesis. Conclusion random constructed based on able accurately predict providing new direction for clinical therapeutic targets.

Язык: Английский

De-succinylation-induced accumulation of TRMT10C in the nucleus plays a detrimental role in coronary microembolization via its m1A modification function DOI Creative Commons
Chenkai Hu, Wen-Sheng Huang, Lei He

и другие.

International Journal of Biological Sciences, Год журнала: 2025, Номер 21(7), С. 2891 - 2920

Опубликована: Апрель 13, 2025

Coronary microembolization (CME) refers to embolism in the coronary microcirculation. This study showed a reduction succinyl transferase (CPT1A) and succinylation substrate (succinyl-CoA) cardiomyocytes CME models, suppressing of mitochondrially localized protein TRMT10C. Suppression promotes KPNA4 recognition two nuclear localization signals (NLSs), KAKR KKK(X)10KVKK, TRMT10C, which induces transport TRMT10C from cytoplasm nucleus rather than mitochondria. Nuclear YTHDF2-mediated decay TAFAZZIN NLRX1 through m1A modifications. The is associated with multiple detrimental effects, such as inflammation mediated by NF-κB NLRP3, reactive oxygen species (ROS) production, suppression mitophagy. knockdown suppressed accumulation nucleus. It restored levels under hypoxia. However, deficiency mitochondria did not improve-or even worsened-with knockdown. Inducing via CPT1A overexpression led redistribution nucleus, likely better approach for improving cardiomyocyte function hypoxia direct reveals novel pathological mechanism underlying suggests potential therapeutic targets this disease.

Язык: Английский

Процитировано

1
RNA methylation modifications in neurodegenerative diseases: Focus on their enzyme system DOI Creative Commons
Lu Liu, Yujia Zhao, Feng Zhang

и другие.

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Neurodegenerative diseases (NDs) constitute a significant public health challenge, as they are increasingly contributing to global mortality and morbidity, particularly among the elderly population. Pathogenesis of NDs is intricate multifactorial. Recently, post-transcriptional modifications (PTMs) RNA, with particular focus on mRNA methylation, have been gaining increasing attention. At present, several regulatory genes associated methylation identified closely neurodegenerative disorders. This review aimed summarize RNA enzymes system, including writer, reader, eraser proteins delve into their functions in central nervous system (CNS), hoping open new avenues for exploring mechanisms therapeutic strategies NDs. studies highlighted critical role development function CNS, abnormalities this process may contribute brain damage NDs, aberrant expression involved has implicated onset

Язык: Английский

Процитировано

1
RNA epigenetic modifications in ovarian cancer: The changes, chances, and challenges DOI
Lele Ye,

Xuyang Yao,

Binbing Xu

и другие.

Wiley Interdisciplinary Reviews - RNA, Год журнала: 2023, Номер 14(5)

Опубликована: Фев. 21, 2023

Abstract Ovarian cancer (OC) is the most common female worldwide. Patients with OC have high mortality because of its complex and poorly understood pathogenesis. RNA epigenetic modifications, such as m 6 A, 1 5 C, are closely associated occurrence development OC. modifications can affect stability mRNA transcripts, nuclear export RNAs, translation efficiency, decoding accuracy. However, there few overviews that summarize link between A modification Here, we discuss molecular cellular functions different how their regulation contributes to pathogenesis By improving our understanding role in etiology OC, provide new perspectives for use diagnosis treatment. This article categorized under: Processing > Editing Modification Disease Development

Язык: Английский

Процитировано

16
Deepm6A-MT: A deep learning-based method for identifying RNA N6-methyladenosine sites in multiple tissues DOI
Guohua Huang,

Xiaohong Huang,

Jinyun Jiang

и другие.

Methods, Год журнала: 2024, Номер 226, С. 1 - 8

Опубликована: Март 12, 2024

Язык: Английский

Процитировано

6
RNA epigenetics in pulmonary diseases: Insights into methylation modification of lncRNAs in lung cancer DOI Open Access

Junjie Jiang,

Minghao Duan,

Zheng Wang

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116704 - 116704

Опубликована: Май 14, 2024

Long non-coding RNAs (lncRNAs) are pivotal controllers of gene expression through epigenetic mechanisms, Methylation, a prominent area study in epigenetics, significantly impacts cellular processes. Various RNA base methylations, including m6A, m5C, m1A, and 2'-O-methylation, profoundly influence lncRNA folding, interactions, stability, thereby shaping their functionality. LncRNAs methylation contribute to tumor development, especially lung cancer. Their roles encompass cell differentiation, proliferation, the generation cancer stem cells, modulation immune responses. Recent studies have suggested that dysregulation can development. Furthermore, modifications lncRNAs hold potential for clinical application Dysregulated promote progression may offer insights into biomarker or therapeutic target. This review summarizes current knowledge its implications epigenetics pulmonary diseases.

Язык: Английский

Процитировано

6
RNA modifications in the progression of liver diseases: from fatty liver to cancer DOI Creative Commons
Simiao Li‐Sauerwine, Wajahat Z. Mehal, Xinshou Ouyang

и другие.

Science China Life Sciences, Год журнала: 2024, Номер 67(10), С. 2105 - 2119

Опубликована: Май 27, 2024

Abstract Non-alcoholic fatty liver disease (NAFLD) has emerged as a prominent global health concern associated with high risk of metabolic syndrome, and impacted substantial segment the population. The spectrum ranges from simple to non-alcoholic steatohepatitis (NASH), which can progress cirrhosis hepatocellular carcinoma (HCC) is increasingly becoming prevalent indication for transplantation. existing therapeutic options NAFLD, NASH, HCC are limited, underscoring urgent need innovative treatment strategies. Insights into gene expression, particularly RNA modifications such N 6 methyladenosine (m A), hold promising avenues interventions. These play integral roles in metabolism cellular functions, encompassing entire NAFLD-NASH-HCC progression. This review will encompass recent insights on diverse modifications, including m A, pseudouridine (ψ), 1 -methyladenosine 5-methylcytidine 5 C) across various species. It uncover their significance crucial aspects steatosis, inflammation, fibrosis, tumorigenesis. Furthermore, prospective research directions implications be explored, advancing our comprehensive understanding intricate interconnected nature these pathological conditions.

Язык: Английский

Процитировано

6
Liquid–liquid phase separation in diseases DOI Creative Commons
Xinyue Zhang, Yuan Lin, Wanlu Zhang

и другие.

MedComm, Год журнала: 2024, Номер 5(7)

Опубликована: Июль 1, 2024

Liquid-liquid phase separation (LLPS), an emerging biophysical phenomenon, can sequester molecules to implement physiological and pathological functions. LLPS implements the assembly of numerous membraneless chambers, including stress granules P-bodies, containing RNA protein. RNA-RNA RNA-protein interactions play a critical role in LLPS. Scaffolding proteins, through multivalent external factors, support protein-RNA interaction networks form condensates involved variety diseases, particularly neurodegenerative diseases cancer. Modulating phenomenon multiple pathogenic proteins for treatment cancer could present promising direction, though recent advances this area are limited. Here, we summarize detail complexity constructing signaling pathways highlight cancers. We also explore modifications on alter progression because these influence certain or formation granules, discuss possibility proper manipulation process restore cellular homeostasis develop therapeutic drugs eradication diseases. This review attempts potential opportunities by elaborating connection between LLPS, modification, their roles

Язык: Английский

Процитировано

6
Methylation modifications in tRNA and associated disorders: Current research and potential therapeutic targets DOI Creative Commons
Zhijing Wu, Ruixin Zhou,

Baizao Li

и другие.

Cell Proliferation, Год журнала: 2024, Номер 57(9)

Опубликована: Июнь 28, 2024

High-throughput sequencing has sparked increased research interest in RNA modifications, particularly tRNA methylation, and its connection to various diseases. However, the precise mechanisms underpinning development of these diseases remain largely elusive. This review sheds light on roles several methylations (m1A, m3C, m5C, m1G, m2G, m7G, m5U, Nm) diverse biological functions, including metabolic processing, stability, protein interactions, mitochondrial activities. It further outlines linked aberrant related enzymes, potential underlying mechanisms. Moreover, disruptions regulation abnormalities tRNA-derived small RNAs (tsRNAs) contribute disease pathogenesis, highlighting their as biomarkers for diagnosis. The also delves into exploration drugs targeting methylation emphasizing therapeutic prospects modulating processes. Continued is imperative a comprehensive comprehension integration molecular diagnosis treatment.

Язык: Английский

Процитировано

5
m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA DOI Creative Commons
Huan Wang,

Linjie Xie,

Haomin Guo

и другие.

Cell & Bioscience, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 14, 2024

Abstract Background N 1 -Methyladenosine (m A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics biological functions m A in adult hippocampal neurogenesis remain enigmatic. Results We found that demethylase Alkbh3 was dramatically enriched neurons neuronal genesis. Functionally, depletion neural stem cells (NSCs) significantly decreased modification, differentiation proliferation coupling with increasing gliogenesis, whereas overexpressing facilitated proliferation. Mechanistically, demethylation Mmp15 by improved its RNA stability translational efficacy, which promoted neurogenesis. Therapeutically, silencing reduced impaired spatial memory mice. Conclusions reveal a novel function on Alkbh3-mediated neurogenesis, shed light advancing regulation as neurotherapeutic strategy.

Язык: Английский

Процитировано

5
Novel Biomarkers for Early Detection of Hepatocellular Carcinoma DOI Creative Commons
Abdelrahman M. Attia, Mohammad Saeid Rezaee‐Zavareh, Soo Young Hwang

и другие.

Diagnostics, Год журнала: 2024, Номер 14(20), С. 2278 - 2278

Опубликована: Окт. 13, 2024

Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality globally. Most patients present with late diagnosis, to poor prognosis. This narrative review explores novel biomarkers for early HCC detection. We conducted comprehensive literature analyzing protein, circulating nucleic acid, metabolite, and quantitative proteomics-based biomarkers, evaluating the advantages limitations each approach. While established markers like alpha-fetoprotein (AFP), des-gamma-carboxy prothrombin, AFP-L3 remain relevant, promising candidates include tumor DNA, microRNAs, long noncoding RNAs, extracellular vesicle, metabolomic biomarkers. Multi-biomarker panels GALAD score, Oncoguard, Helio liver test show promise improved diagnostic accuracy. Non-invasive approaches urine gut microbiome analysis are also emerging possibilities. Integrating these current screening protocols holds significant potential earlier detection patient outcomes. Future research should explore multi-biomarker panels, omics technologies, artificial intelligence further enhance diagnosis management.

Язык: Английский

Процитировано

5