Machine learning‐based radiomics to distinguish pulmonary nodules between lung adenocarcinoma and tuberculosis

Thoracic Cancer, Год журнала: 2024, Номер 15(6), С. 466 - 476

Опубликована: Янв. 8, 2024

Abstract Background Radiomics is increasingly utilized to distinguish pulmonary nodules between lung adenocarcinoma (LUAD) and tuberculosis (TB). However, it remains unclear whether different segmentation criteria, such as the inclusion or exclusion of cavity region within nodules, affect results. Methods A total 525 patients from two medical centers were retrospectively enrolled. The radiomics features extracted according regions interest (ROI) criteria. Multiple logistic regression models trained predict pathology: (1) clinical model relied on clinical‐radiological semantic features; (2) (radiomics+ radiomics−) ROIs (including excluding cavities); (3) composite (composite+ composite−) incorporated both above. Results In testing set, radiomics+/− composite+/− still possessed efficient prediction performance (AUC ≥ 0.94), while AUC was 0.881. validation only 0.717, that ranged 0.801 0.825. all significantly superior ( p < 0.05). Whether ROI included excluded had no significant effect these vs. radiomics−, composite+ > Conclusions present study established a machine learning‐based strategy for differentiating LUAD TB lesions. including may exert predictive ability.

Язык: Английский

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Single‐cell RNA sequencing reveals the mechanism of PI3K/AKT/mTOR signaling pathway activation in lung adenocarcinoma by KRAS mutation

The Journal of Gene Medicine, Год журнала: 2024, Номер 26(1)

Опубликована: Янв. 1, 2024

Abstract Background Aberrant activation of the phosphatidlinositol 3‐kinase (PI3K)/protein kinase B (AKT)/mammalian target rapamycin (mTOR) signaling pathway has been shown to play an important role in lung adenocarcinoma (LUAD). The effect KRAS mutations, one signatures LUAD, on PI3K/AKT/mTOR LUAD remains unclear. Methods Seurat package and principal component analysis were used for cell categorization single‐cell RNA sequencing data LUAD. AUCell score was assess activity pathway. Meanwhile, using gene expression profiles mutation Cancer Genome Atlas dataset, patients categorized into KRAS‐mutant (KRAS‐MT) KRAS‐wild‐types (KRAS‐WT), corresponding enrichment scores calculated set analysis. Finally, subpopulation cells with highest identified, copy number variation profile this inscribed inferCNV CMap database utilized make predictions drugs targeting subpopulation. Results There is higher epithelial high KRAS, PIK3CA, AKT1 PDPK1. In particular, we found significantly levels associated KRAS‐MT than KRAS‐WT. We identified a GRB2 + presence amplified genes within its able subpopulations, such as wortmannin, palbociclib angiogenesis inhibitor. Conclusions present study provides basic theory result mutations.

Язык: Английский

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Ubiquitin-specific protease 54 regulates GLUT1-mediated aerobic glycolysis to inhibit lung adenocarcinoma progression by modifying p53 degradation

Oncogene, Год журнала: 2024, Номер 43(26), С. 2025 - 2037

Опубликована: Май 14, 2024

Язык: Английский

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New strategies for lung cancer diagnosis and treatment: applications and advances in nanotechnology

Biomarker Research, Год журнала: 2024, Номер 12(1)

Опубликована: Ноя. 13, 2024

Lung cancer leads in causing cancer-related mortality worldwide, continually posing a significant threat to human health. Current imaging diagnostic techniques, while offering non-invasive detection, suffer from issues such as insufficient sensitivity and the risks associated with radiation exposure. Pathological diagnosis, gold standard for confirmation, also faces challenges like invasiveness high costs. In treatment, surgery, radiotherapy, chemotherapy are main modalities, each encountering related precision, environmental adaptability, side effects. Nanotechnology's advancement provides new solutions diagnosis treatment of lung cancer, promising enhance accuracy reduce effects during treatment. This article introduces types nanomaterials used field comprehensive overview current research on application nanotechnology early screening, monitoring summarizing ongoing clinical findings.

Язык: Английский

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Preparation and mechanism analysis of non-contact respiratory sensor based on ZnO/RGO composites

Applied Surface Science, Год журнала: 2022, Номер 599, С. 154031 - 154031

Опубликована: Июнь 27, 2022

Язык: Английский

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Smoking-induced CCNA2 expression promotes lung adenocarcinoma tumorigenesis by boosting AT2/AT2-like cell differentiation

Cancer Letters, Год журнала: 2024, Номер 592, С. 216922 - 216922

Опубликована: Май 3, 2024

Язык: Английский

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Identification of GPD1L as a Potential Prognosis Biomarker and Associated with Immune Infiltrates in Lung Adenocarcinoma

Mediators of Inflammation, Год журнала: 2023, Номер 2023, С. 1 - 13

Опубликована: Март 30, 2023

Lung adenocarcinoma (LUAD) is one of the most prevalent pathological kinds lung cancer, which a common form cancer that has high death rate. Over past several years, growing studies have indicated GPD1L was involved in advancement number different cancers. However, its clinical significance LUAD not been investigated. In this study, following an examination TGCA datasets, we found displayed dysregulated state wide variety cancers; led us to believe essential regulator progression malignancies. addition, expression much lower tissues when compared with nontumor specimens. According findings ROC tests, able effectively identify specimens from samples AUC value 0.828 (95% confidence interval: 0.793 0.863). On basis low clearly related both N stage and stage. Moreover, based on Kaplan-Meier survival elevated strong indicator considerably improved overall (OS) disease-specific (DSS). stages were be independent prognostic indicators for disease-free patients, according multivariate analyses. Based analysis, C-indexes calibration plots nomogram demonstrated effective prediction performance patients. Besides, positively mast cells, eosinophils, Tcm, TFH, iDC, DC, macrophages, while negatively associated Th2 NK CD56dim Tgd, Treg, neutrophils. Finally, qRT-PCR demonstrate had significant amount LUAD. Additionally, results functional overexpression inhibiting effect proliferation cells. general, our study suggested potential serve as diagnostic marker

Язык: Английский

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Baseline whole-lung CT features deriving from deep learning and radiomics: prediction of benign and malignant pulmonary ground-glass nodules

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Авг. 17, 2023

Objective To develop and validate the model for predicting benign malignant ground-glass nodules (GGNs) based on whole-lung baseline CT features deriving from deep learning radiomics. Methods This retrospective study included 385 GGNs 3 hospitals, confirmed by pathology. We used 239 Hospital 1 as training internal validation set; 115 31 2 external test sets 2, respectively. An additional 32 stable with more than five years of follow-up were set 3. evaluated clinical morphological at chest extracted radiomics simultaneously. Besides, image are further assisted using convolutional neural network. back-propagation network to construct prediction models different collocations training. The area under receiver operator characteristic curve (AUC) was compare performance among models. Delong differences in AUC between pairwise. Results integrated clinical-morphological features, radiomic (CMRI) performed best models, achieved highest set, 1, which 0.886 (95% CI: 0.841-0.921), 0.830 (95%CI: 0.749-0.893) 0.879 0.712-0.968), In above three sets, CMRI other significant (all P &lt; 0.05). Moreover, accuracy 96.88%. Conclusion feasible predict GGNs, is helpful refined management GGNs.

Язык: Английский

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Overdiagnosis and overtreatment of ground‐glass nodule‐like lung cancer

Asia-Pacific Journal of Clinical Oncology, Год журнала: 2024, Номер unknown

Опубликована: Янв. 4, 2024

Abstract Lung cancer has had one of the highest incidences and mortality in world over last few decades, which aided promotion popularization screening for lung ground‐glass nodules (GGNs). People have great psychological anxiety about GGN because chance that it will develop into cancer, makes clinical treatment a generally excessive phenomenon. Overdiagnosis recently been mentioned literature. An important research emphasis is how to reduce incidence overdiagnosis overtreatment. This paper discusses from different aspects characterize occurrence overtreatment, future screening, follow‐up, approaches.

Язык: Английский

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The Dual Roles of S-Nitrosylation of Proteins in Cancer: Molecular Mechanisms and Recent Advancements

Cancer Insight, Год журнала: 2024, Номер 3(2), С. 37 - 48

Опубликована: Март 1, 2024

<p class="MsoNormal" style="text-align: justify;"><span lang="EN-US" style="font-family: Nunito; color: #212529; background: white;">Protein S-nitrosylation (SNO), emerging as an important posttranslational modification, involves covalent addition of nitric oxide (NO) to the sulfur atom cysteine in proteins. Accumulated evidence suggests that protein SNO plays crucial roles pathophysiological mechanisms cancer, which is attracting great attention. However, there are still controversies about whether S-nitrosylated proteins act oncogenic or tumor suppressors cancer. In this review, we provide overview early and latest regarding underlying mechanism dual effort clarify its contribution progression. It has been well established restrain progression several types while they have exhibited activities promoting cell proliferation inhibiting apoptosis some other kinds Interestingly, also highlighted both anti-cancer pro-tumorigenic cancer diseases. Finally, current limitations future research prospects presented. The targeting will new opportunities for drug development through in-depth exploration SNO-mediated signaling pathways.</span></p>

Язык: Английский

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