A neuronal blueprint for directional mechanosensation in larval zebrafish

Current Biology, Год журнала: 2021, Номер 31(7), С. 1463 - 1475.e6

Опубликована: Фев. 5, 2021

Язык: Английский

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Experimental models of chemically induced Parkinson’s disease in zebrafish at the embryonic larval stage: a systematic review

Journal of Toxicology and Environmental Health Part B, Год журнала: 2023, Номер 26(4), С. 201 - 237

Опубликована: Март 1, 2023

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in substantia nigra that results decrease dopamine levels, resulting motor-type disturbances. Different vertebrate models, such as rodents and fish, have been used to study PD. In recent decades, Danio rerio (zebrafish) has emerged potential model for investigation diseases due its homology nervous system humans. this context, systematic review aimed identify publications reported utilization neurotoxins an experimental parkinsonism zebrafish embryos larvae. Ultimately, 56 articles were identified searching three databases (PubMed, Web Science, Google Scholar). Seventeen studies using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 4 1-methyl-4-phenylpyridinium (MPP+), 24 6-hydroxydopamine (6-OHDA), 6 paraquat/diquat, 2 rotenone, other types unusual induce PD selected. Neurobehavioral function, motor activity, neuron markers, oxidative stress biomarkers, relevant parameters embryo-larval examined. summary, provides information help researchers determine which chemical suitable parkinsonism, according effects induced

Язык: Английский

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Projections of the Diencephalospinal Dopaminergic System to Peripheral Sense Organs in Larval Zebrafish (Danio rerio)

Frontiers in Neuroanatomy, Год журнала: 2018, Номер 12

Опубликована: Март 19, 2018

Dopaminergic neurons of the descending diencephalospinal system are located in posterior tuberculum zebrafish (Danio rerio), and correspond mammals to A11 group hypothalamus thalamus. In larval zebrafish, they likely only source central dopaminergic projections periphery. Here, we characterized tubercular fibers projecting peripheral sense organs, with a focus on lateral line neuromasts. We labelled identified catecholaminergic their by combining two immunofluorescence techniques, (i) using an antibody against Tyrosine hydroxylase, (ii) GFP transgenic expressing either membrane-anchored track fibers, or Synaptophysin-GFP fusion visualize putative synapses. applied CLARITY method six days old whole larvae stain analyze confocal microscopy. found that all neuromasts receive direct innervation neurons, tracked these detail. addition, anterior ganglia, extensive arborizations around terminal projection field afferent hindbrain medial octavolateralis nucleus. Therefore, may affect information at different processing stages. Additional innervate trigeminal ganglion, observed fine skin arborization patterns similar free sensory nerve endings. also detected potentially innervating inner ear epithelia. A11-type broadly modulate senses. briefly report sympathetic labeled our experiments, developing intestine, swim bladder abdominal organs.

Язык: Английский

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Evoking and tracking zebrafish eye movement in multiple larvae with ZebEyeTrack

Nature Protocols, Год журнала: 2018, Номер 13(7), С. 1539 - 1568

Опубликована: Июль 1, 2018

Язык: Английский

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Neuromodulatory Selection of Motor Neuron Recruitment Patterns in a Visuomotor Behavior Increases Speed

Current Biology, Год журнала: 2020, Номер 30(5), С. 788 - 801.e3

Опубликована: Фев. 21, 2020

Язык: Английский

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Evolutionary convergence of a neural mechanism in the cavefish lateral line system

eLife, Год журнала: 2022, Номер 11

Опубликована: Июнь 16, 2022

Animals can evolve dramatic sensory functions in response to environmental constraints, but little is known about the neural mechanisms underlying these changes. The Mexican tetra, Astyanax mexicanus , a leading model study genetic, behavioral, and physiological evolution by comparing eyed surface populations blind cave populations. We compared neurophysiological responses of posterior lateral line afferent neurons motor across A. reveal how shifts function may shape behavioral diversity. These studies indicate differences intrinsic signaling gain control Elevated endogenous activity identified lower threshold cavefish relative fish increased evoked potentials during hair cell deflection cavefish. next measured effect inhibitory corollary discharges from hindbrain efferent onto afferents locomotion. discovered that three independently derived have evolved persistent locomotion, suggesting for first time partial loss system be an evolutionary mechanism adaptation vertebrate system.

Язык: Английский

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Feed Intake Regulation in Fish: Implications for Aquaculture

Reviews in Fisheries Science & Aquaculture, Год журнала: 2024, Номер unknown, С. 1 - 53

Опубликована: Авг. 2, 2024

Understanding how feed intake is regulated in fish essential for feeding efficiency aquaculture. For this regulation, the central nervous system orchestrates behavioral and physiological responses involving homeostatic hedonic regulatory systems. Knowledge about these mechanisms variable, paper reviews available information following a time frame of processes occurring before, during after feeding. Furthermore, comprehensive understanding regulation achieving responsible aquaculture practices since goes beyond nutritional considerations, impacting growth, health, performance. Therefore, impact on inclusion ingredients, stressors, environmental factors, sexual dimorphism, ontogeny are also described.

Язык: Английский

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Neuromodulatory processing in the bi-pathway brain architecture

Current Opinion in Neurobiology, Год журнала: 2025, Номер 93, С. 103055 - 103055

Опубликована: Май 23, 2025

Язык: Английский

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Dopamine system, cerebellum, and nucleus ruber in fish and mammals

Development Growth & Differentiation, Год журнала: 2017, Номер 59(4), С. 219 - 227

Опубликована: Май 1, 2017

Small teleost fish including zebrafish and medaka have been used as animal models for research because of their small body size, vast amounts eggs produced, rapid development, low husbandry costs, transparency during embryogenesis. Although the size appearance seem different, mammals human still possess anatomical functional similarities in brains. This review summarizes brain structures functions between mammalian brains, focusing on dopamine system, regionalization cerebellum, presence nucleus ruber.

Язык: Английский

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Establishment of the miniature fish speciesDanionella translucidaas a genetically and optically tractable neuroscience model

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2018, Номер unknown

Опубликована: Окт. 16, 2018

Summary Integrative studies of the diverse neuronal networks that govern social behavior are hindered by lack methods to record neural activity comprehensively across entire brain. The recent development miniature fish Danionella cerebrum as a model organism offers one potential solution, small size and optical transparency these animals makes it possible visualize circuit throughout nervous system 1–4 . Here, we establish feasibility using for socially reinforced learning showing adult exhibit strong affiliative tendencies, interactions can serve reinforcer in an appetitive conditioning paradigm. Fish exhibited acute ability identify conspecifics distinguish them from closely related species, which was mediated both visual particularly olfactory cues. These behaviors were abolished pharmacological genetic interference with oxytocin signaling, demonstrating conservation key mechanisms observed other vertebrates 5–11 Our work validates tool understanding brain general, its modulation neuropeptide signaling particular.

Язык: Английский

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