Organization of the catecholaminergic systems in the brain of lungfishes, the closest living relatives of terrestrial vertebrates DOI
Jesús M. López, Agustı́n González

The Journal of Comparative Neurology, Journal Year: 2017, Volume and Issue: 525(14), P. 3083 - 3109

Published: June 26, 2017

Abstract Lungfishes are a group of sarcopterygian fishes currently considered the closest living relatives tetrapods, and represent an interesting for study evolutionary traits in transition from to tetrapods. Catecholaminergic systems brain among most carefully analyzed neurotransmitter vertebrate groups. Their organization shows major shared characteristics, although particular each class have also been found, primarily between anamniotes amniotes. Given relevance lungfishes terms, present provides first comprehensive detailed map catecholaminergic structures two representative species lungfishes, African lungfish ( Protopterus dolloi ) Australian Neoceratodus forsteri ), as revealed by immunohistochemistry. Distinct groups cells were observed olfactory bulb, pallium, preoptic area telencephalon, subpallium is devoid these cells. Hypothalamic diencephalic detected and, particular, dopaminergic nucleus periventricular organ was evidenced with dopamine antibodies but not anti‐tyrosine hydroxylase. A well developed mesostriatal system formed conspicuous midbrain tegmentum profuse innervation subpallium. Comparison results those other classes vertebrates numerous common highlights features different actinopterygian that resemble amphibians

Language: Английский

Experimental models of chemically induced Parkinson’s disease in zebrafish at the embryonic larval stage: a systematic review DOI

Paola Briñez-Gallego,

Dennis Guilherme da Costa Silva,

Marcos Freitas Cordeiro

et al.

Journal of Toxicology and Environmental Health Part B, Journal Year: 2023, Volume and Issue: 26(4), P. 201 - 237

Published: March 1, 2023

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in substantia nigra that results decrease dopamine levels, resulting motor-type disturbances. Different vertebrate models, such as rodents and fish, have been used to study PD. In recent decades, Danio rerio (zebrafish) has emerged potential model for investigation diseases due its homology nervous system humans. this context, systematic review aimed identify publications reported utilization neurotoxins an experimental parkinsonism zebrafish embryos larvae. Ultimately, 56 articles were identified searching three databases (PubMed, Web Science, Google Scholar). Seventeen studies using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 4 1-methyl-4-phenylpyridinium (MPP+), 24 6-hydroxydopamine (6-OHDA), 6 paraquat/diquat, 2 rotenone, other types unusual induce PD selected. Neurobehavioral function, motor activity, neuron markers, oxidative stress biomarkers, relevant parameters embryo-larval examined. summary, provides information help researchers determine which chemical suitable parkinsonism, according effects induced

Language: Английский

Citations

11
A neuronal blueprint for directional mechanosensation in larval zebrafish DOI Creative Commons
Gema Valera, Daniil A. Markov, Kayvan Bijari

et al.

Current Biology, Journal Year: 2021, Volume and Issue: 31(7), P. 1463 - 1475.e6

Published: Feb. 5, 2021

Language: Английский

Citations

26
Projections of the Diencephalospinal Dopaminergic System to Peripheral Sense Organs in Larval Zebrafish (Danio rerio) DOI Creative Commons
Melanie Haehnel, António M. Fernandes,

Margit Böhler

et al.

Frontiers in Neuroanatomy, Journal Year: 2018, Volume and Issue: 12

Published: March 19, 2018

Dopaminergic neurons of the descending diencephalospinal system are located in posterior tuberculum zebrafish (Danio rerio), and correspond mammals to A11 group hypothalamus thalamus. In larval zebrafish, they likely only source central dopaminergic projections periphery. Here, we characterized tubercular fibers projecting peripheral sense organs, with a focus on lateral line neuromasts. We labelled identified catecholaminergic their by combining two immunofluorescence techniques, (i) using an antibody against Tyrosine hydroxylase, (ii) GFP transgenic expressing either membrane-anchored track fibers, or Synaptophysin-GFP fusion visualize putative synapses. applied CLARITY method six days old whole larvae stain analyze confocal microscopy. found that all neuromasts receive direct innervation neurons, tracked these detail. addition, anterior ganglia, extensive arborizations around terminal projection field afferent hindbrain medial octavolateralis nucleus. Therefore, may affect information at different processing stages. Additional innervate trigeminal ganglion, observed fine skin arborization patterns similar free sensory nerve endings. also detected potentially innervating inner ear epithelia. A11-type broadly modulate senses. briefly report sympathetic labeled our experiments, developing intestine, swim bladder abdominal organs.

Language: Английский

Citations

29
Evoking and tracking zebrafish eye movement in multiple larvae with ZebEyeTrack DOI
Florian A. Dehmelt,

Adam von Daranyi,

Claire Leyden

et al.

Nature Protocols, Journal Year: 2018, Volume and Issue: 13(7), P. 1539 - 1568

Published: July 1, 2018

Language: Английский

Citations

28
Neuromodulatory Selection of Motor Neuron Recruitment Patterns in a Visuomotor Behavior Increases Speed DOI Creative Commons
Urvashi Prasad Jha, Vatsala Thirumalai

Current Biology, Journal Year: 2020, Volume and Issue: 30(5), P. 788 - 801.e3

Published: Feb. 21, 2020

Language: Английский

Citations

26
Evolutionary convergence of a neural mechanism in the cavefish lateral line system DOI Creative Commons
Elias T. Lunsford, Alexandra Paz, Alex C. Keene

et al.

eLife, Journal Year: 2022, Volume and Issue: 11

Published: June 16, 2022

Animals can evolve dramatic sensory functions in response to environmental constraints, but little is known about the neural mechanisms underlying these changes. The Mexican tetra, Astyanax mexicanus , a leading model study genetic, behavioral, and physiological evolution by comparing eyed surface populations blind cave populations. We compared neurophysiological responses of posterior lateral line afferent neurons motor across A. reveal how shifts function may shape behavioral diversity. These studies indicate differences intrinsic signaling gain control Elevated endogenous activity identified lower threshold cavefish relative fish increased evoked potentials during hair cell deflection cavefish. next measured effect inhibitory corollary discharges from hindbrain efferent onto afferents locomotion. discovered that three independently derived have evolved persistent locomotion, suggesting for first time partial loss system be an evolutionary mechanism adaptation vertebrate system.

Language: Английский

Citations

15
Dopamine system, cerebellum, and nucleus ruber in fish and mammals DOI Open Access
Hideaki Matsui

Development Growth & Differentiation, Journal Year: 2017, Volume and Issue: 59(4), P. 219 - 227

Published: May 1, 2017

Small teleost fish including zebrafish and medaka have been used as animal models for research because of their small body size, vast amounts eggs produced, rapid development, low husbandry costs, transparency during embryogenesis. Although the size appearance seem different, mammals human still possess anatomical functional similarities in brains. This review summarizes brain structures functions between mammalian brains, focusing on dopamine system, regionalization cerebellum, presence nucleus ruber.

Language: Английский

Citations

26
Establishment of the miniature fish speciesDanionella translucidaas a genetically and optically tractable neuroscience model DOI Creative Commons

Ariadne Penalva-Tena,

Jacob Bedke,

Alice Gaudin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2018, Volume and Issue: unknown

Published: Oct. 16, 2018

Summary Integrative studies of the diverse neuronal networks that govern social behavior are hindered by lack methods to record neural activity comprehensively across entire brain. The recent development miniature fish Danionella cerebrum as a model organism offers one potential solution, small size and optical transparency these animals makes it possible visualize circuit throughout nervous system 1–4 . Here, we establish feasibility using for socially reinforced learning showing adult exhibit strong affiliative tendencies, interactions can serve reinforcer in an appetitive conditioning paradigm. Fish exhibited acute ability identify conspecifics distinguish them from closely related species, which was mediated both visual particularly olfactory cues. These behaviors were abolished pharmacological genetic interference with oxytocin signaling, demonstrating conservation key mechanisms observed other vertebrates 5–11 Our work validates tool understanding brain general, its modulation neuropeptide signaling particular.

Language: Английский

Citations

25
Forebrain Dopamine System Regulates Inner Ear Auditory Sensitivity to Socially Relevant Acoustic Signals DOI Creative Commons
Jonathan T. Perelmuter, Anthony B. Wilson, Joseph A. Sisneros

et al.

Current Biology, Journal Year: 2019, Volume and Issue: 29(13), P. 2190 - 2198.e3

Published: June 13, 2019

Language: Английский

Citations

25
Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity DOI Creative Commons
Lily Sarrafha, Drew Neavin, Gustavo Morrone Parfitt

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(9), P. 107525 - 107525

Published: Aug. 3, 2023

The hypothalamus is a region of the brain that plays an important role in regulating body functions and behaviors. There growing interest human pluripotent stem cells (hPSCs) for modeling diseases affect hypothalamus. Here, we established hPSC-derived organoid differentiation protocol to model cellular diversity this region. Using hPSC line with tyrosine hydroxylase (TH)-TdTomato reporter dopaminergic neurons (DNs) other TH-expressing cells, interrogated DN-specific pathways electrophysiologically active organoids. Single-cell RNA sequencing (scRNA-seq) revealed diverse neuronal non-neuronal cell types mature We identified several molecularly distinct hypothalamic DN subtypes demonstrated different developmental maturities. Our

Language: Английский

Citations

8