From Short- to Long-Term Effects of C-Section Delivery on Microbiome Establishment and Host Health DOI Creative Commons
David Ríos-Covián, Philippe Langella, Rebeca Martín

и другие.

Microorganisms, Год журнала: 2021, Номер 9(10), С. 2122 - 2122

Опубликована: Окт. 9, 2021

The establishment of gut microbiota has been proven to be impacted by several factors during pregnancy, delivery, and neonate periods. body evidence describing C-section delivery (CSD) as one the most disruptive events early life expanded in recent years, concluding that CSD results a drastic change patterns. When comparing composition babies with vaginally delivered (VD) babies, former show microbiome closely resembles found environment mother’s skin, while VD more similar vaginal microbiome. Although these alterations normal tend disappear first months life, they still affect host health mid–long term since correlated higher risk infections non-transmissible diseases, such inflammatory allergies, metabolic diseases. In this phenomenon also studied other mammals, shedding light on mechanisms involved effects health. addition, strategies revert disruptions microbiomes caused are currently process development evaluation. review, we discuss advances research, from alteration possible development.

Язык: Английский

Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health DOI Creative Commons

Kirsten Berding,

Klára Vlčková, Wolfgang Marx

и другие.

Advances in Nutrition, Год журнала: 2020, Номер 12(4), С. 1239 - 1285

Опубликована: Дек. 22, 2020

Язык: Английский

Процитировано

240
Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis DOI Open Access
Anna Ratsika, Martin G. Codagnone, Siobhain M. O’Mahony

и другие.

Nutrients, Год журнала: 2021, Номер 13(2), С. 423 - 423

Опубликована: Янв. 28, 2021

Microbes colonize the human body during first moments of life and coexist with host throughout lifespan. Intestinal microbiota their metabolites aid in programming important bodily systems such as immune central nervous system critical temporal windows development, possible structural functional implications These developmental perinatally (during 1000 days) are susceptible timepoints for insults that can endure long lasting effects on microbiota-gut-brain axis. Environmental parental factors like genetics, mental health, nutrition, delivery feeding mode, exposure to antibiotics, activation composition antenatally, all able modulate mother infant may thus regulate functions. Among these factors, early nutrition plays a pivotal role perinatal modulation offspring from birth This review aims present current data impact priming influencing microbial coexistence development.

Язык: Английский

Процитировано

130
Effects of vaginal microbiota transfer on the neurodevelopment and microbiome of cesarean-born infants: A blinded randomized controlled trial DOI Creative Commons

Lepeng Zhou,

Wen Qiu, Jie Wang

и другие.

Cell Host & Microbe, Год журнала: 2023, Номер 31(7), С. 1232 - 1247.e5

Опубликована: Июнь 16, 2023

Язык: Английский

Процитировано

56
Microbiota-brain interactions: Moving toward mechanisms in model organisms DOI Creative Commons
Jatin Nagpal, John F. Cryan

Neuron, Год журнала: 2021, Номер 109(24), С. 3930 - 3953

Опубликована: Окт. 16, 2021

Язык: Английский

Процитировано

89
Role of Bifidobacteria on Infant Health DOI Creative Commons
Silvia Saturio, Alicja Nogacka, Guadalupe Monserrat Alvarado-Jasso

и другие.

Microorganisms, Год журнала: 2021, Номер 9(12), С. 2415 - 2415

Опубликована: Ноя. 23, 2021

Bifidobacteria are among the predominant microorganisms during infancy, being a dominant microbial group in healthy breastfed infant and playing crucial role newborns development. Not only levels of Bifidobacterium genus but also profile quantity different bifidobacterial species have been demonstrated to be relevance health. Although no definitive proof is available on causal association, reduced bifidobacteria perhaps most frequently observed alteration intestinal microbiota diseases. Moreover, strains extensively studied by their probiotic attributes. This review compiles information about composition function since beginning life, describing perinatal factors affecting them, implications health alterations infancy. In addition, this gathers exhaustive pre-clinical clinical studies with as probiotics neonates.

Язык: Английский

Процитировано

82
Volatility as a Concept to Understand the Impact of Stress on the Microbiome DOI Creative Commons
Thomaz F. S. Bastiaanssen, Anand Gururajan, Marcel van de Wouw

и другие.

Psychoneuroendocrinology, Год журнала: 2020, Номер 124, С. 105047 - 105047

Опубликована: Дек. 8, 2020

The microbiome-gut-brain-axis is a complex phenomenon spanning several dynamic systems in the body which can be parsed at molecular, cellular, physiological and ecological level. A growing of evidence indicates that this axis particularly sensitive to effects stress it may relevant resilience susceptibility. Although stress-induced changes composition microbiome have been reported, degree compositional change over time, we define as volatility, has not subject in-depth scrutiny. Using chronic psychosocial paradigm male mice, report volatility significantly correlated with readouts response, including behaviour corticosterone response. We then validated these findings second independent group stressed mice. Additionally, assessed relationship between parameters cohort health volunteers who were undergoing academic exams similar observations. Finally, found inter-species similarities response on functional Our research highlights underscores informative value parameter should considered all future analyses microbiome.

Язык: Английский

Процитировано

72
Effects of Microbiota Imbalance in Anxiety and Eating Disorders: Probiotics as Novel Therapeutic Approaches DOI Open Access
Elisabet Navarro‐Tapia, Laura Almeida-Toledano, Giorgia Sebastiani

и другие.

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(5), С. 2351 - 2351

Опубликована: Фев. 26, 2021

Anxiety and eating disorders produce a physiological imbalance that triggers alterations in the abundance composition of gut microbiota. Moreover, gut–brain axis can be altered by several factors such as diet, lifestyle, infections, antibiotic treatment. Diet generate dysbiosis, which affects immune system responses, inflammation mechanisms, intestinal permeability, well production short chain fatty acids neurotransmitters microbiota, are essential to correct function neurological processes. Recent studies indicated patients with generalized anxiety or (anorexia nervosa, bulimia binge-eating disorders) show specific profile this partially restored after single multi-strain probiotic supplementation. Following PRISMA methodology, current review addresses main microbial signatures observed and/or importance probiotics preventive therapeutic tool these pathologies.

Язык: Английский

Процитировано

66
The composition of human vaginal microbiota transferred at birth affects offspring health in a mouse model DOI Creative Commons
Eldin Jašarević,

Elizabeth Hill,

Patrick J. Kane

и другие.

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Ноя. 1, 2021

Newborns are colonized by maternal microbiota that is essential for offspring health and development. The composition of these pioneer communities exhibits individual differences, but the importance this early-life heterogeneity to outcomes not understood. Here we validate a human microbiota-associated model in which fetal mice cesarean delivered gavaged with defined vaginal microbial communities. This replicates inoculation occurs during birth reveals lasting effects on metabolism, immunity, brain community-specific manner. effect amplified prior gestation obesogenic or dysbiotic environment where placental ileum development altered, an augmented immune response increases rates mortality. Collectively, describe translationally relevant examine role specific outcomes, demonstrate prenatal dramatically shapes postnatal inoculation.

Язык: Английский

Процитировано

65
Critical windows of early-life microbiota disruption on behaviour, neuroimmune function, and neurodevelopment DOI Creative Commons
Caoimhe M.K. Lynch, Caitlin S.M. Cowan, Thomaz F. S. Bastiaanssen

и другие.

Brain Behavior and Immunity, Год журнала: 2022, Номер 108, С. 309 - 327

Опубликована: Дек. 17, 2022

Numerous studies have emphasised the importance of gut microbiota during early life and its role in modulating neurodevelopment behaviour. Epidemiological shown that early-life antibiotic exposure can increase an individual's risk developing immune metabolic diseases. Moreover, preclinical long-term antibiotic-induced microbial disruption enduring effects on physiology, brain function However, these not investigated impact targeted depletion critical developmental windows how this may be related to neurodevelopmental outcomes. Here, we addressed gap by administering a broad-spectrum oral cocktail (ampicillin, gentamicin, vancomycin, imipenem) mice one three putative windows: postnatal (PN; P2-9), pre-weaning (PreWean; P12-18), or post-weaning (Wean; P21-27) periods assessed physiology behaviour later life. Our results demonstrate has into adolescence structure caecal microbiome, especially for weaning period. Further, show selectively alters circulating cells modifies neurophysiology adolescence, including altered myelin-related gene expression prefrontal cortex microglial morphology basolateral amygdala. We also observed sex time-dependent anxiety-related behavioural outcomes adulthood. Antibiotic-induced had limited subtle social did any significant depressive-like behaviour, short-term working, recognition memory. Overall, study highlights development but microbiota-targeted perturbations

Язык: Английский

Процитировано

63
Gut microbial taxa elevated by dietary sugar disrupt memory function DOI Creative Commons
Emily E. Noble, C. Anders Olson, Elizabeth A. Davis

и другие.

Translational Psychiatry, Год журнала: 2021, Номер 11(1)

Опубликована: Март 31, 2021

Abstract Emerging evidence highlights a critical relationship between gut microbiota and neurocognitive development. Excessive consumption of sugar other unhealthy dietary factors during early life developmental periods yields changes in the microbiome as well impairments. However, it is unclear whether these two outcomes are functionally connected. Here we explore excessive added sugars negatively impacts memory function via microbiome. Rats were given free access to sugar-sweetened beverage (SSB) adolescent stage Memory anxiety-like behavior assessed adulthood bacterial brain transcriptome analyses conducted. Taxa-specific microbial enrichment experiments examined functional sugar-induced outcomes. Chronic impaired adult hippocampal-dependent without affecting body weight or behavior. Adolescent SSB adolescence also altered microbiome, including elevated abundance species genus Parabacteroides ( P. distasonis johnsonii ) that correlated with hippocampal function. Transferred specific taxa rats adulthood. Hippocampus revealed gene expression intracellular kinase synaptic neurotransmitter signaling pathways, whereas pathways associated metabolic function, neurodegenerative disease, dopaminergic signaling. Collectively results identify role for “dysbiosis” mediating detrimental effects on

Язык: Английский

Процитировано

62