Philosophical Transactions of the Royal Society B Biological Sciences,
Год журнала:
2022,
Номер
377(1858)
Опубликована: Июль 11, 2022
Social
behaviour
is
an
essential
component
of
human
life
and
deficits
in
social
function
are
seen
across
multiple
psychiatric
conditions
with
high
morbidity.
However,
there
currently
no
FDA-approved
treatments
for
dysfunction.
Since
cognition
rely
on
signalling
processes
acting
concert
various
neural
networks,
aimed
at
may
inherently
require
a
combinatorial
approach.
Here,
we
describe
the
neurobiology
oxytocin
endocannabinoid
systems
as
well
translational
evidence
their
use
treating
symptoms
domain.
We
leverage
this
to
propose
network-based
framework
that
involves
pharmacology,
psychotherapy,
non-invasive
brain
stimulation
skills
training
combinatorially
target
trans-diagnostic
impairment.
Lastly,
discuss
combined
endocannabinoids
within
our
proposed
illustrative
strategy
treat
specific
aspects
function.
Using
provides
roadmap
actionable
treatment
strategies
neuropsychiatric
This
article
part
theme
issue
‘Interplays
between
other
neuromodulators
shaping
complex
behaviours’.
Translational Psychiatry,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июль 15, 2024
Abstract
There
is
much
interest
in
targeting
the
activity
oxytocin
system
to
regulate
social
bonding.
However,
studies
with
exogenous
administration
of
face
caveats
its
low
stability,
poor
brain
permeability
and
insufficient
receptor
specificity.
The
use
a
small-molecule
receptor-specific
agonist
could
overcome
these
caveats.
Prior
testing
potential
effects
brain-penetrant
clinical
settings,
it
important
assess
how
such
an
would
affect
bonds
animal
models.
facultatively
monogamous
prairie
voles
(
Microtus
ochrogaster
),
capable
forming
long-term
attachments
between
adult
individuals,
are
ideal
rodent
model
for
testing.
Therefore,
series
experiments
we
investigated
recently
developed
LIT-001
on
acquisition
expression
partner
preference,
well-established
pair
bonding,
voles.
(10
mg/kg,
intraperitoneal),
as
expected,
facilitated
preference
when
administered
prior
4hr
cohabitation.
In
contrast,
while
animals
injected
vehicle
after
cohabitation
exhibited
significant
that
were
did
not
show
preference.
This
result
suggests
OXTR
activation
during
bonding
can
inhibit
difference
versus
was
due
basal
differences
experiments,
had
no
if
following
shorter
(2hr-long)
Instead,
this
agrees
hypothesis
receptors
acts
signal
presence
partner.
Our
results
indicate
pharmacological
crucially
depend
phase
attachments.
Neuropsychopharmacology,
Год журнала:
2024,
Номер
49(12), С. 1934 - 1946
Опубликована: Июль 17, 2024
Autism
Spectrum
Disorders
(ASD)
are
neurodevelopmental
disorders
whose
diagnosis
relies
on
deficient
social
interaction
and
communication
together
with
repetitive
behaviours.
Multiple
studies
have
highlighted
the
potential
of
oxytocin
(OT)
to
ameliorate
behavioural
abnormalities
in
animal
models
subjects
ASD.
Clinical
trials,
however,
yielded
disappointing
results.
Our
study
aimed
at
assessing
effects
different
regimens
OT
administration
Oprm1
null
mouse
model
We
assessed
intranasal
injected
once
doses
(0.15,
0.3,
0.6
IU)
time
points
(5,
15,
30
min)
following
administration,
or
chronically,
ASD-related
behaviours
(social
preference,
stereotypies,
anxiety,
nociception)
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 24, 2024
Abstract
The
mesolimbic
dopamine
(DA)
system
has
been
implicated
in
pair
bond
formation.
However,
involvements
of
DA
release,
real
time
activities,
and
electrophysiological
activities
D1/D2
medium
spiny
neurons
(MSNs)
the
nucleus
accumbens
(NAc)
shell
bonding
remain
unclear.
This
work
verified
that
male
mandarin
voles
after
released
higher
levels
NAc
displayed
D1
MSNs
activity
lower
D2
upon
sniffing
their
partners
compared
to
an
unknown
female.
Moreover,
induced
differential
alterations
both
synaptic
plasticity
neuronal
intrinsic
excitability
MSNs.
In
addition,
chemogenetic
inhibition
ventral
pallidum
(VP)
-projecting
enhanced
formation,
while
activation
VP-projecting
inhibited
These
findings
suggest
different
/
regulated
by
increasing
release
may
be
a
neurobiological
mechanism
underlying
Philosophical Transactions of the Royal Society B Biological Sciences,
Год журнала:
2022,
Номер
377(1858)
Опубликована: Июль 11, 2022
Social
behaviour
is
an
essential
component
of
human
life
and
deficits
in
social
function
are
seen
across
multiple
psychiatric
conditions
with
high
morbidity.
However,
there
currently
no
FDA-approved
treatments
for
dysfunction.
Since
cognition
rely
on
signalling
processes
acting
concert
various
neural
networks,
aimed
at
may
inherently
require
a
combinatorial
approach.
Here,
we
describe
the
neurobiology
oxytocin
endocannabinoid
systems
as
well
translational
evidence
their
use
treating
symptoms
domain.
We
leverage
this
to
propose
network-based
framework
that
involves
pharmacology,
psychotherapy,
non-invasive
brain
stimulation
skills
training
combinatorially
target
trans-diagnostic
impairment.
Lastly,
discuss
combined
endocannabinoids
within
our
proposed
illustrative
strategy
treat
specific
aspects
function.
Using
provides
roadmap
actionable
treatment
strategies
neuropsychiatric
This
article
part
theme
issue
‘Interplays
between
other
neuromodulators
shaping
complex
behaviours’.
