Fine-grained descending control of steering in walking Drosophila

Cell, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Miniature linear and split-belt treadmills reveal mechanisms of adaptive motor control in walking Drosophila

Current Biology, Год журнала: 2024, Номер 34(19), С. 4368 - 4381.e5

Опубликована: Авг. 30, 2024

Язык: Английский

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Visual and motor signatures of locomotion dynamically shape a population code for feature detection in Drosophila

eLife, Год журнала: 2022, Номер 11

Опубликована: Окт. 27, 2022

Natural vision is dynamic: as an animal moves, its visual input changes dramatically. How can the system reliably extract local features from dominated by self-generated signals? In Drosophila , diverse are represented a group of projection neurons with distinct tuning properties. Here, we describe connectome-based volumetric imaging strategy to measure visually evoked neural activity across this population. We show that jointly population, and shared gain factor improves trial-to-trial coding fidelity. A subset these neurons, tuned small objects, modulated two independent signals associated self-movement, motor-related signal, motion signal rotation animal. These inputs adjust sensitivity feature detectors locomotor cycle, selectively reducing their during saccades restoring it intersaccadic intervals. This work reveals for reliable detection locomotion.

Язык: Английский

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Fine-grained descending control of steering in walkingDrosophila

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 17, 2023

Summary Locomotion involves rhythmic limb movement patterns that originate in circuits outside the brain. Purposeful locomotion requires descending commands from brain, but we do not understand how these are structured. Here investigate this issue, focusing on control of steering walking Drosophila . First, describe different “gestures” associated with maneuvers. Next, identify a set neurons whose activity predicts steering. Focusing two cell types downstream distinct brain networks, show they evoke specific gestures: one lengthens strides turn, while other attenuates inside turn. Notably, single neuron can have opposite effects during locomotor rhythm phases, and networks positioned to implement phase-specific gating. Together, our results purposeful emerges cells drive specific, coordinated modulations low-level patterns.

Язык: Английский

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Inhibitory control of locomotor statistics in walkingDrosophila

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 16, 2024

In order to forage for food, many animals regulate not only specific limb movements but the statistics of locomotor behavior over time, example switching between long-range dispersal behaviors and more localized search depending on availability resources. How pre-motor circuits such is clear. Here we took advantage robust changes in evoked by attractive odors walking

Язык: Английский

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Diverse prey capture strategies in teleost larvae

Опубликована: Фев. 10, 2025

Animal behavior is adapted to the sensory environment in which it evolved, while also being constrained by physical limits, evolutionary history, and developmental trajectories. The hunting of larval zebrafish ( Danio rerio ), a cyprinid native streams Eastern India, has been well characterized. However, unknown if complement sequence movements employed during prey capture universal across freshwater teleosts. Here, we explore syntax fish belonging clade Percomorpha , whose last common ancestor with cyprinids lived ∼240 million years ago. We compared four cichlid species from Lake Tanganyika endemic deep benthic parts lake Lepidiolamprologus attenuatus Lamprologus ocellatus Neolamprologus multifasciatus ) or inhabiting rivers Astatotilapia burtoni that medaka Oryzias latipes found rice paddies East Asia. Using high speed videography neural networks, tracked eye extracted swim kinematics larvae these five species. Notably, repertoire cichlids broader than zebrafish, but shares basic features, such as convergence, positioning centrally binocular visual field, discrete bouts, including two kinds strikes. In contrast, continuously, track monocularly without position laterally before capturing them side swing. This configuration kinematic motifs suggests may judge distance predominantly motion parallax, mainly use cues. Together, our study documents diversification locomotor oculomotor adaptations among teleost larvae.

Язык: Английский

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Inhibitory control explains locomotor statistics in walking Drosophila

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(16)

Опубликована: Апрель 17, 2025

In order to forage for food, many animals regulate not only specific limb movements but the statistics of locomotor behavior, switching between long-range dispersal and local search depending on resource availability. How premotor circuits is clear. Here, we analyze model their modulation by attractive food odor in walking Drosophila . Food evokes three motor regimes flies: baseline walking, upwind running during odor, behavior following loss. During search, find that flies adopt higher angular velocities slower ground speeds turn longer periods same direction. We further different mean speed these state changes influence length odor-evoked runs. next developed a simple neural control suggests contralateral inhibition plays key role regulating statistical features locomotion. As fly connectome predicts decussating inhibitory neurons lateral accessory lobe (LAL), gained genetic access subset tested effects behavior. identified one population whose activation induces all signature regulates velocity at offset. second population, including single LAL neuron pair, bidirectionally speed. Together, our work develops biologically plausible computational architecture captures locomotion across behavioral states identifies substrates computations.

Язык: Английский

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Olfactory projection neuron rewiring in the brain of an ecological specialist

Cell Reports, Год журнала: 2025, Номер 44(5), С. 115615 - 115615

Опубликована: Апрель 25, 2025

Язык: Английский

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How do neonicotinoids affect social bees? Linking proximate mechanisms to ecological impacts

Advances in insect physiology, Год журнала: 2023, Номер unknown, С. 191 - 253

Опубликована: Янв. 1, 2023

Язык: Английский

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Miniature linear and split-belt treadmills reveal mechanisms of adaptive motor control in walkingDrosophila

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 24, 2024

Abstract To navigate complex environments, walking animals must detect and overcome unexpected perturbations. One technical challenge when investigating adaptive locomotion is measuring behavioral responses to precise perturbations during naturalistic walking; another that manipulating neural activity in sensorimotor circuits often reduces spontaneous locomotion. these obstacles, we introduce miniature treadmill systems for coercing tracking 3D kinematics of Drosophila . By systematically comparing three experimental setups, show flies compelled walk on the linear have similar stepping freely flies, while tethered are subtly different. Genetically silencing mechanosensory neurons alters step across all speeds, inter-leg coordination remains intact. We also found can maintain a forward heading split-belt by adapting distance their middle legs. Overall, new insights demonstrate utility treadmills studying insect

Язык: Английский

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