Device, Год журнала: 2023, Номер 1(4), С. 100116 - 100116
Опубликована: Окт. 1, 2023
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер 36(26)
Опубликована: Апрель 13, 2024
This work introduces NeoMag, a system designed to enhance cell mechanics assays in substrate deformation studies. NeoMag uses multidomain magneto-active materials mechanically actuate the substrate, transmitting reversible mechanical cues cells. The boasts full flexibility alternating loading modes, seamlessly adapting both upright and inverted microscopes. substrates facilitate mechanobiology on 2D 3D cultures. integration of with nanoindenters allows for precise evaluation cellular properties under varying modes. is used study impact astrocytes, simulating conditions akin traumatic brain injury ischemic stroke. results reveal local heterogeneous changes astrocyte stiffness, influenced by orientation subcellular regions relative strain. These stiffness variations, exceeding 50% stiffening softening, deformations significantly alter calcium dynamics. Furthermore, sustained induce actin network reorganization activate Piezo1 channels, leading an initial increase followed long-term inhibition events. Conversely, fast dynamic transiently channels disrupt network, causing softening. findings unveil functional alterations astrocytes during deformation, illustrating multiple opportunities this technology offers.
Язык: Английский
Процитировано
19
Exploration, Год журнала: 2024, Номер unknown
Опубликована: Май 30, 2024
Cell behavior is intricately intertwined with the in vivo microenvironment and endogenous pathways. The ability to guide cellular toward specific goals can be achieved by external stimuli, notably electricity, light, ultrasound, magnetism, simultaneously harnessed through biomaterial-mediated responses. These triggers become focal points within body due interactions biomaterials, facilitating a range of pathways: electrical signal transmission, biochemical cues, drug release, cell loading, modulation mechanical stress. Stimulus-responsive biomaterials hold immense potential biomedical research, establishing themselves as pivotal point interdisciplinary pursuits. This comprehensive review systematically elucidates prevalent physical stimuli their corresponding biomaterial response mechanisms. Moreover, it delves deeply into application domain biomedicine. A balanced assessment distinct stimulation techniques provided, along discussion merits limitations. aims shed light on future trajectory stimulus-responsive disease treatment outline prospects for development. poised spark novel concepts advancing intelligent, biomaterials.
Язык: Английский
Процитировано
16
Bioactive Materials, Год журнала: 2024, Номер 40, С. 345 - 365
Опубликована: Июнь 15, 2024
Язык: Английский
Процитировано
16
Nature Reviews Bioengineering, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
4
Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Simple templating of actuators via micro-topographical patterning (STAMP) enables precisely muscle fibers within engineered tissues, enabling fabrication complex multi-oriented architectures such as a biomimetic iris.
Язык: Английский
Процитировано
2
Annual Review of Biomedical Engineering, Год журнала: 2024, Номер 26(1), С. 223 - 245
Опубликована: Июль 3, 2024
The impact of tissue engineering has extended beyond a traditional focus in medicine to the rapidly growing realm biohybrid robotics. Leveraging living actuators as functional components machines been central this field, generating range compelling demonstrations robots capable muscle-powered swimming, walking, pumping, gripping, and even computation. In review, we highlight key advances fabricating tissue-scale cardiac skeletal muscle for applications. We discuss areas future growth including scalable manufacturing, integrated feedback control, predictive modeling also propose methods ensuring inclusive bioethics-focused pedagogy emerging discipline. hope review motivates next generation biomedical engineers advance rational design practical use applications ranging from telesurgery manufacturing on- off-world exploration.
Язык: Английский
Процитировано
11
Micromachines, Год журнала: 2024, Номер 15(3), С. 313 - 313
Опубликована: Фев. 24, 2024
This article explores the challenges of continuum and magnetic soft robotics for medical applications, extending from model development to an interdisciplinary perspective. First, we established a unified framework based on algebra geometry. The research progress in principle models, data-driven, hybrid modeling were then analyzed depth. Simultaneously, numerical analysis was constructed. Furthermore, expanded encompass conducted comprehensive analysis, including in-depth case study. Current need address meta-problems identified through discussion. Overall, this review provides novel perspective understanding complexities paving way researchers assimilate knowledge domain rapidly.
Язык: Английский
Процитировано
7
PLoS ONE, Год журнала: 2024, Номер 19(3), С. e0298863 - e0298863
Опубликована: Март 26, 2024
Advancing human induced pluripotent stem cell derived cardiomyocyte (hiPSC-CM) technology will lead to significant progress ranging from disease modeling, drug discovery, regenerative tissue engineering. Yet, alongside these potential opportunities comes a critical challenge: attaining mature hiPSC-CM tissues. At present, there are multiple techniques promote maturity of hiPSC-CMs including physical platforms and culture protocols. However, when it making quantitative comparisons functional behavior, limited options for reliably reproducibly computing metrics that suitable direct cross-system comparison. In addition, the current standard obtained time-lapse images cardiac microbundle contraction reported in field (i.e., post forces, average stress) do not take full advantage available information present data full-field displacements strains). Thus, we “MicroBundleCompute,” computational framework automatic quantification morphology-based mechanical movies microbundles. Briefly, this offers tools segmentation, tracking, analysis brightfield phase contrast beating It is straightforward implement, runs without user intervention, requires minimal input parameter setting selection, computationally inexpensive. paper, describe methods underlying framework, show results our extensive validation studies, demonstrate utility exploring heterogeneous deformations strains as metrics. With manuscript, disseminate “MicroBundleCompute” an open-source tool with aim automated microbundles more accessible community.
Язык: Английский
Процитировано
4
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Skeletal muscle's elegant protein-based architecture powers motion throughout the animal kingdom, with its constituent actomyosin complexes driving intra- and extra-cellular motion. Classical motors recently developed soft actuators cannot match packing density contractility of individual muscle fibers that scale to power ants elephants alike. Accordingly, interdisciplinary fields robotics tissue engineering have combined efforts build living can a new class robots be more energy-efficient, dexterous, safe than existing motor-powered hydraulic paradigms. Doing so ethically at scale─creating meter-scale constructs from sustainable progenitor cell lines─has inspired innovations in biomaterials culture methodology. We weave discussions biology, materials chemistry, engineering, biohybrid design review state art actuator biofabrication. Looking forward, we outline vision for robotic systems tie recent progress long-term research goals.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 149681 - 149681
Опубликована: Фев. 17, 2024
Язык: Английский
Процитировано
3