Revolutionizing drug formulation development: The increasing impact of machine learning

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 202, С. 115108 - 115108

Опубликована: Сен. 27, 2023

Язык: Английский

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Stimuli responsiveness of recent biomacromolecular systems (concept to market): A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129901 - 129901

Опубликована: Фев. 3, 2024

Язык: Английский

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Long acting injectables for the treatment of prostate cancer

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 100, С. 105996 - 105996

Опубликована: Июль 31, 2024

Язык: Английский

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Recent Advances in the Titanium-Based Catalysts for Ring-Opening Polymerization

ACS Omega, Год журнала: 2024, Номер 9(28), С. 29983 - 29993

Опубликована: Июль 5, 2024

At present, economic development and daily life cannot be separated from organic synthetic polymers. However, a large number of nondegradable polymers have caused serious pollution to the environment. It is necessary for sustainable use biodegradable materials instead traditional polymers, but it not yet comparable in performance cost competitor will replace. Therefore, there long way go develop effective synthesis methods. Through ring-opening polymerization, some cyclic monomers, such as ε-caprolactone or lactide, can synthesized into which only replace fields also applications drug delivery, surgical consumables, human implant materials, bone etc. Ring-opening polymerization potential candidate solving environmental pollution. For catalysts are very important, among titanium attracted much attention because their high efficiency, economy, nontoxicity. In this paper, status organotitanium compounds reviewed, including effects different ligand structures on behavior polymer structure, its trend prospected. We hope that review helpful developing efficient catalysts.

Язык: Английский

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Miniaturized screening and performance prediction of tailored subcutaneous extended-release formulations for preclinical in vivo studies

European Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 196, С. 106733 - 106733

Опубликована: Фев. 24, 2024

Microencapsulation of active pharmaceutical ingredients (APIs) for preparation long acting injectable (LAI) formulations is an auspicious technique to enable preclinical characterization a broad variety APIs, ideally independent their physicochemical and pharmacokinetic (PK) characteristics. During early API discovery, tunable LAI may pharmacological proof-of-concept the given candidates by tailoring level plasma exposure over duration various timespans. Although numerous reports on small scale methods LAIs utilizing copolymers lactic glycolic acid (PLGA) polymers (PLA) highlight potential, application in formulation screening use vivo studies yet very limited. Transfer from downscale experiments hampered large number with simultaneously limited available amount lower sub-gram scale, lack stability deficient tunability sustained release. We hereby present novel comprehensive platform tool tailored extended-release formulations, aiming support ranging required levels A small-scale spray drying process was successfully implemented using air brush based instrument PLGA PLA formulations. Using Design Experiments (DoE), 250 mg demonstrated suffice identification dominant polymer characteristics largest impact release capability individual API. BI-3231, hydrophilic weakly acidic compound good water solubility permeability, but low metabolic stability, used as exemplary model one many during discovery. Furthermore, vitro correlation (IVIVC) rate established mice, which enabled prediction concentration plateaus after single subcutaneous injection, only dissolution profiles screened By doses acute sub-chronic experiments, we demonstrate practical BI-3231. Pharmacological could be whilst circumventing need multiple administration result extensive hepatic metabolism superseding tailoring.

Язык: Английский

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Long-acting parenteral formulations of hydrophilic drugs, proteins, and peptide therapeutics: mechanisms, challenges, and therapeutic benefits with a focus on technologies

Drug Delivery and Translational Research, Год журнала: 2024, Номер 15(4), С. 1156 - 1180

Опубликована: Дек. 11, 2024

Язык: Английский

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Oil-Based Long-Acting Injectable Systems: Formulation Insights and Future Perspectives

Опубликована: Янв. 1, 2025

Язык: Английский

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Envisaging the Future of Long-Acting Injectables and Implants

Опубликована: Янв. 1, 2025

Язык: Английский

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PLGA-based long-acting injectable (LAI) formulations

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113758 - 113758

Опубликована: Апрель 1, 2025

Язык: Английский

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From in vitro to in vivo: A comprehensive guide to IVIVC development for long-acting therapeutics

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 199, С. 114906 - 114906

Опубликована: Июнь 5, 2023

Язык: Английский

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