Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Angina
pectoris
(AP),
a
clinical
syndrome
characterized
by
paroxysmal
chest
pain,
is
caused
insufficient
blood
supply
to
the
coronary
arteries
and
sudden
temporary
myocardial
ischemia
hypoxia.
Long-term
AP
typically
induces
other
cardiovascular
events,
including
infarction
heart
failure,
posing
serious
threat
patient
safety.
However,
AP's
complex
pathological
mechanisms
developmental
processes
introduce
significant
challenges
in
rapid
diagnosis
accurate
treatment
of
its
different
subtypes,
stable
angina
(SAP),
unstable
(UAP),
variant
(VAP).
Omics
research
has
contributed
significantly
revealing
various
diseases
with
development
high-throughput
sequencing
approaches.
The
application
multi-omics
approaches
effectively
interprets
systematic
information
on
from
perspective
genes,
RNAs,
proteins,
metabolites.
Integrating
introduces
novel
avenues
for
identifying
biomarkers
distinguish
subtypes.
This
study
reviewed
articles
related
elaborate
progress
(including
genomics,
transcriptomics,
proteomics,
metabolomics),
summarized
their
applications
screening
employed
discriminate
multiple
delineated
integration
methods
Finally,
we
discussed
advantages
disadvantages
applying
single-omics
approach
distinguishing
diverse
Our
review
demonstrated
that
technologies
preferable
quick
precise
three
types,
namely
SAP,
UAP,
VAP.
Frontiers in Genetics,
Год журнала:
2025,
Номер
16
Опубликована: Март 5, 2025
Colorectal
cancer
(CRC)
is
a
prevalent
malignancy
worldwide,
often
treated
with
chemotherapy
despite
its
limitations,
including
adverse
effects
and
resistance.
The
traditional
Chinese
medicine
(TCM)
Jianpi
formula
has
been
demonstrated
to
improve
efficacy
of
chemotherapy,
however
the
underlying
mechanisms
still
need
be
explored.
In
this
study,
we
aim
screen
bioactive
peptides
derived
from
blood
CRC
patients
through
peptidomics
explore
molecular
candidate
in
inhibition
using
multi-omics
analysis.
recruited
10
who
had
received
either
adjuvant
or
combined
after
surgery.
We
collected
plasma
samples
at
2
cycles
therapy
performed
peptidomic
analysis
on
these
samples.
differentially
were
screened
model
HCT116
cells
vitro.
To
investigate
mechanism
YG-22's
colorectal
cell
line
HCT116,
analysis,
transcriptome,
metabolome,
chromatin
accessibility,
H3K4Me3
histone
methylation,
NF-κB
binding
site
analyses.
Differential
identified
formula.
Among
peptides,
YG-22
exhibited
strongest
cytotoxic
effect
cells,
reducing
viability
dose-
time-dependent
manner.
Transcriptome
highlighted
that
treatment
modulates
key
pathways
associated
lysosome-mediated
degradation
apoptosis.
Metabolomic
profiling
further
indicated
disruptions
tumor-supportive
metabolic
pathways.
Chromatin
accessibility
modification
analyses
suggested
induces
epigenetic
reprogramming.
Additionally,
resulted
significant
changes
pathway
activation.
This
study
demonstrates
combining
TCM
enriches
landscape
generates
strong
antitumor
activity.
Furthermore,
also
lays
foundation
for
development
peptide-based
therapies
highlights
value
modern
therapeutic
strategies
management.
Molecular Neurobiology,
Год журнала:
2023,
Номер
61(6), С. 3272 - 3295
Опубликована: Ноя. 20, 2023
Abstract
Phospholipidomics
is
a
specialized
branch
of
lipidomics
that
focuses
on
the
characterization
and
quantification
phospholipids.
By
using
sensitive
analytical
techniques,
phospholipidomics
enables
researchers
to
better
understand
metabolism
activities
phospholipids
in
brain
disorders
such
as
Alzheimer’s
Parkinson’s
diseases.
In
brain,
identifying
specific
phospholipid
biomarkers
can
offer
valuable
insights
into
underlying
molecular
features
biochemistry
these
diseases
through
variety
techniques.
has
emerged
promising
tool
clinical
studies,
with
immense
potential
advance
our
knowledge
neurological
enhance
diagnosis
treatment
options
for
patients.
present
review
paper,
we
discussed
numerous
applications
tools
particular
focus
field.
exploring
phospholipids’
functions
research,
provided
could
aid
clinicians
harnessing
full
prospective
this
innovative
practice
improve
patient
outcomes
by
providing
more
potent
treatments
Graphical
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 753 - 753
Опубликована: Июнь 7, 2024
Nowadays,
lipidomics
plays
a
crucial
role
in
the
investigation
of
novel
biomarkers
various
diseases.
Its
implementation
into
field
clinical
analysis
led
to
identification
specific
lipids
and/or
significant
changes
their
plasma
levels
patients
suffering
from
cancer,
Alzheimer’s
disease,
sepsis,
and
many
other
diseases
pathological
conditions.
Profiling
determination
concentrations
could
also
be
helpful
case
drug
therapy
management,
especially
combination
with
therapeutic
monitoring
(TDM).
Here,
for
first
time,
combined
approach
based
on
TDM
colistin,
last-resort
antibiotic,
lipidomic
profiling
is
presented
study
critically
ill
male
patient
Pseudomonas
aeruginosa-induced
pneumonia.
Implementation
innovative
analytical
approaches
(online
capillary
electrophoresis
tandem
mass
spectrometry,
CZE-MS/MS)
(liquid
chromatography–tandem
LC-MS/MS)
was
demonstrated.
The
CZE-MS/MS
strategy
confirmed
chosen
colistin
dosing
regimen,
leading
stable
samples.
determined
samples
reached
required
minimal
inhibitory
concentration
1
μg/mL.
complex
545
collected
during
after
therapy.
Some
individual
were
good
agreement
previous
studies
dealing
sepsis.
represents
starting
point
identifying
particular
that
correlate
antimicrobial
inflammation
management.
