Journal of the Science of Food and Agriculture, Год журнала: 2024, Номер 104(14), С. 8916 - 8927
Опубликована: Июль 4, 2024
Quinoa contains far more nutrients than any traditional grain crop. It is known that terpenoids in quinoa have anti-inflammatory and antitumor effects, but their role reversing drug resistance remains unclear.
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114643 - 114643
Опубликована: Апрель 7, 2023
Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, reduced performance drugs is predominantly due to inherent over expression ATP-binding cassette (ABC) transporter proteins on cell membrane, resulting deprived uptake drugs, augmenting drug detoxification, and DNA repair. In addition physiological abnormalities extensive blood flow, MDR phenotypes exhibit improved apoptotic threshold efflux efficiency. These severe consequences have substantially directed researchers fabrication advanced strategies, such as co-delivery along with generations inhibitors, augmented dosage regimens frequency administration, well combinatorial treatment options, among others. this review, we emphasize different reasons mechanisms responsible for cancer, including but not limited known mediated by permeability glycoprotein (P-gp) other pumps, uptake, altered repair, targets, Further, an emphasis specific cancers that share pathogenesis executing effluxed common provided. Then, aspects related nanomaterials-based supramolecular programmable designs (organic- inorganic-based materials), physical approaches (light- ultrasound-based therapies), are discussed, highlighting unsolved issues future advancements. Finally, summarize review interesting perspectives trends, exploring further opportunities overcome MDR.
Язык: Английский
Процитировано
145
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Янв. 22, 2024
Abstract The incidence of nasopharyngeal carcinoma (NPC) exhibits significant variations across different ethnic groups and geographical regions, with Southeast Asia North Africa being endemic areas. Of note, Epstein-Barr virus (EBV) infection is closely associated almost all the undifferentiated NPC cases. Over past three decades, radiation therapy chemotherapy have formed cornerstone treatment. However, recent advancements in immunotherapy introduced a range promising approaches for managing NPC. In light these developments, it has become evident that deeper understanding tumor microenvironment (TME) crucial. TME serves dual function, acting as promoter tumorigenesis while also orchestrating immunosuppression, thereby facilitating cancer progression enabling immune evasion. Consequently, comprehensive comprehension its intricate involvement initiation, progression, metastasis imperative development effective anticancer drugs. Moreover, given complexity inter-patient heterogeneity, personalized treatment should be designed to maximize therapeutic efficacy circumvent drug resistance. This review aims provide an in-depth exploration within context EBV-induced NPC, particular emphasis on pivotal role regulating intercellular communication shaping responses. Additionally, offers concise summary resistance mechanisms potential strategies their reversal, specifically relation chemoradiation therapy, targeted immunotherapy. Furthermore, advances clinical trials pertaining are discussed.
Язык: Английский
Процитировано
41
Drug Resistance Updates, Год журнала: 2024, Номер 73, С. 101058 - 101058
Опубликована: Янв. 19, 2024
Язык: Английский
Процитировано
22
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(9), С. 3834 - 3854
Опубликована: Июнь 3, 2024
Immunotherapy is an important cancer treatment method that offers hope for curing patients. While immunotherapy has achieved initial success, a major obstacle to its widespread adoption the inability benefit majority of The success or failure closely linked tumor's immune microenvironment. Recently, there been significant attention on strategies regulate tumor microenvironment in order stimulate anti-tumor responses immunotherapy. distinctive physical properties and design flexibility nanomedicines have extensively utilized target cells (including tumor-associated macrophages (TAMs), T cells, myeloid-derived suppressor (MDSCs), fibroblasts (TAFs)), offering promising advancements In this article, we reviewed aimed at targeting various focus models are based nanomedicines, with goal inducing enhancing improve It worth noting combining other treatments, such as chemotherapy, radiotherapy, photodynamic therapy, can maximize therapeutic effects. Finally, identified challenges nanotechnology-mediated needs overcome more effective nanosystems.
Язык: Английский
Процитировано
20
Drug Resistance Updates, Год журнала: 2023, Номер 71, С. 101004 - 101004
Опубликована: Авг. 21, 2023
Язык: Английский
Процитировано
44
Drug Resistance Updates, Год журнала: 2023, Номер 71, С. 101005 - 101005
Опубликована: Авг. 21, 2023
Multidrug resistance in pancreatic cancer poses a significant challenge clinical treatment. Bufalin (BA), compound found secretions from the glands of toads, may help overcome this problem. However, severe cardiotoxicity thus far has hindered its application. Hence, present study aimed to develop cell membrane-camouflaged and BA-loaded polylactic-co-glycolic acid nanoparticle (CBAP) assess potential counter chemoresistance cancer.The toxicity CBAP was evaluated by electrocardiogram, body weight, distress score, nesting behavior mice. In addition, anticarcinoma activity underlying mechanism were investigated both vitro vivo.CBAP significantly mitigated BA-mediated acute enhanced sensitivity several drugs, such as gemcitabine, 5-fluorouracil, FOLFIRINOX. Mechanistically, directly bound nucleotide-binding oligomerization domain containing protein 2 (NOD2) inhibited expression nuclear factor kappa-light-chain-enhancer activated B cells. This inhibits ATP-binding cassette transporters, which are responsible for cells.Our findings indicate that NOD2. Combining with standard-of-care chemotherapeutics represents safe efficient strategy treatment cancer.
Язык: Английский
Процитировано
34
European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 257, С. 115495 - 115495
Опубликована: Май 16, 2023
Язык: Английский
Процитировано
28
Drug Resistance Updates, Год журнала: 2023, Номер 72, С. 101016 - 101016
Опубликована: Ноя. 3, 2023
Drug resistance remains a major challenge in cancer treatment, necessitating the development of novel strategies to overcome it. Protein arginine methyltransferases (PRMTs) are enzymes responsible for epigenetic methylation, which regulates various biological and pathological processes, as result, they attractive therapeutic targets overcoming anti-cancer drug resistance. The ongoing small molecules targeting PRMTs has resulted generation chemical probes modulating most facilitated clinical treatment advanced oncology targets, including PRMT1 PRMT5. In this review, we summarize mechanisms underlying protein methylation roles specific driving Furthermore, highlight potential implications PRMT inhibitors decreasing promote formation maintenance drug-tolerant cells via several mechanisms, altered efflux transporters, autophagy, DNA damage repair, stem cell-related function, epithelial-mesenchymal transition, disordered tumor microenvironment. Multiple preclinical trials have demonstrated that inhibitors, particularly PRMT5 can sensitize drugs, chemotherapeutic, targeted therapeutic, immunotherapeutic agents. Combining with existing will be promising approach enhanced knowledge complex functions guide future may help identify new indications.
Язык: Английский
Процитировано
27
ACS Nano, Год журнала: 2024, Номер 18(26), С. 17267 - 17281
Опубликована: Июнь 13, 2024
Intrinsic or acquired resistance to chemical drugs severely limits their therapeutic efficacy in cancer treatment. Various intracellular antioxidant molecules, particularly glutathione (GSH), play a crucial role maintaining redox homeostasis by mitigating the overproduced reactive oxygen species (ROS) due rapid cell proliferation. Notably, these antioxidants also eliminate chemical-drug-induced ROS, eventually diminishing cytotoxicity and rendering them less effective. In this study, we combined erastin, GSH biosynthesis inhibitor, with 2'-deoxy-5-fluorouridine 5'-monophosphate sodium salt (FdUMP), an ROS-based drug, effectively disrupt reverse chemotherapy resistance. Therefore, efficient ferroptosis apoptosis were simultaneously induced for enhanced antitumor effects. Additionally, employed small interfering RNA targeting PD-L1 (siPD-L1) as third agent block immune-checkpoint recognition CD8
Язык: Английский
Процитировано
17
Drug Resistance Updates, Год журнала: 2024, Номер 73, С. 101062 - 101062
Опубликована: Янв. 29, 2024
Язык: Английский
Процитировано
12